Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Апрель 29, 2024
Abstract
Fixed
dose
combinations
(FDCs)
incorporating
two
or
three
medicines
in
a
single
inhaler
have
been
created
to
enhance
patient
compliance
and
hence
clinical
outcomes.
However,
the
development
of
dry
powder
inhalers
(DPIs),
particularly
for
FDCs,
faces
challenges
pertinent
formulation
uniformity
reproducibility.
Therefore,
this
project
aimed
employ
nanotechnology
develop
FDC
DPIs
market-leading
medicines—fluticasone
propionate
(FP)
salmeterol
xinafoate
(SAL)—for
asthma
management.
Nanoaggregates
were
prepared
using
novel
biocompatible
biodegradable
poly(ester
amide)
based
on
amino
acid
tyrosine,
utilising
one-step
interfacial
polymerisation
process.
The
produced
tyrosine
poly
(ester
drug-loaded
nanoparticles
evaluated
content
uniformity,
PSA,
FTIR,
TEM,
DSC,
XRD
aerodynamic
performance
(in
vitro
vivo).
optimised
demonstrated
high
entrapment
efficiency–
>
90%.
terms
emitted
dose,
fine
particle
fraction
respirable
was
superior
carrier-based
marketed
product.
In-vivo
studies
showed
that
FP
(above
formulation)
SAL
reached
lungs
mice
reproducible
manner.
These
results
highlight
superiority
FP/SAL
via
process,
which
can
be
used
as
cost-effective
efficient
method
alleviate
burden
asthma.
Materials Today Bio,
Год журнала:
2024,
Номер
25, С. 100966 - 100966
Опубликована: Янв. 22, 2024
Pulmonary
drug
delivery
has
the
advantages
of
being
rapid,
efficient,
and
well-targeted,
with
few
systemic
side
effects.
In
addition,
it
is
non-invasive
good
patient
compliance,
making
a
highly
promising
mode.
However,
there
have
been
limited
studies
on
via
pulmonary
inhalation
compared
oral
intravenous
modes.
This
paper
summarizes
basic
research
clinical
translation
for
treatment
diseases
provides
insights
into
latest
advances
in
delivery.
The
discusses
processing
methods
delivery,
carriers
(with
focus
various
types
nanoparticles),
devices,
applications
(e.g.,
COVID-19,
inhaled
vaccines,
diagnosis
diseases,
diabetes
mellitus)
an
updated
summary
recent
advances.
Furthermore,
this
describes
progress
lung
expands
use
drugs
other
diseases.
Bioengineering,
Год журнала:
2024,
Номер
11(8), С. 788 - 788
Опубликована: Авг. 4, 2024
Nanotechnology
plays
a
pivotal
role
in
the
biomedical
field,
especially
synthesis
and
regulation
of
drug
particle
size.
Reducing
particles
to
micron
or
nanometer
scale
can
enhance
bioavailability.
Supercritical
fluid
technology,
as
green
development
strategy,
is
expected
resolve
challenges
thermal
degradation,
uneven
size,
organic
solvent
residue
faced
by
traditional
methods
such
milling
crystallization.
This
paper
provides
an
insight
into
application
super-stable
homogeneous
intermix
formulating
technology
(SHIFT)
super-table
pure-nanomedicine
formulation
(SPFT)
developed
based
on
supercritical
fluids
for
dispersion
micronization.
These
technologies
significantly
solubility
permeability
hydrophobic
drugs
controlling
size
morphology,
modified
show
excellent
therapeutic
efficacy
treatment
hepatocellular
carcinoma,
pathological
scarring,
corneal
neovascularization,
their
performance
are
highlighted
when
administered
through
multiple
routes
administration.
Overall,
have
opened
efficient
pathway
clinical
development,
which
reduce
side
effects
efficacy.
Pharmaceuticals,
Год журнала:
2023,
Номер
16(12), С. 1658 - 1658
Опубликована: Ноя. 28, 2023
In
this
review,
an
extensive
analysis
of
dry
powder
inhalers
(DPIs)
is
offered,
focusing
on
their
characteristics,
formulation,
stability,
and
manufacturing.
The
advantages
pulmonary
delivery
were
investigated,
as
well
the
significance
particle
size
in
drug
deposition.
preparation
DPI
formulations
was
also
comprehensively
explored,
including
physico-chemical
characterization
powders,
processing
techniques,
formulation
considerations.
addition
to
manufacturing
procedures,
testing
methods
discussed,
providing
insights
into
development
evaluation
formulations.
This
review
explores
design
basics
critical
attributes
specific
DPIs,
highlighting
optimization
achieve
effective
inhalation
therapy.
Additionally,
morphology
stability
3
capsules
(Spiriva,
Braltus,
Onbrez)
offering
valuable
properties
these
Altogether,
findings
contribute
a
deeper
understanding
DPIs
development,
performance,
dosage
forms.
Expert Opinion on Drug Delivery,
Год журнала:
2023,
Номер
20(11), С. 1553 - 1571
Опубликована: Ноя. 2, 2023
Introduction
With
the
increase
in
elderly
population
and
prevalence
of
multiple
medical
conditions,
medication
adherence,
efficacy
have
become
crucial
for
effective
management
their
health.
The
aging
faces
unique
challenges
that
need
to
be
addressed
through
advancements
drug
delivery
systems
formulation
technologies.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 7529 - 7546
Опубликована: Июль 1, 2024
Nanoparticles
have
the
advantages
of
improving
solubility
poorly
water-soluble
drugs,
facilitating
drug
across
biological
barriers,
and
reducing
macrophage
phagocytosis
in
pulmonary
delivery.
However,
nanoparticles
a
small
aerodynamic
particle
size,
which
makes
it
difficult
to
achieve
optimal
deposition
when
delivered
directly
lungs.
Therefore,
delivering
lungs
effectively
has
become
popular
research
topic.
Asian Journal of Atmospheric Environment,
Год журнала:
2025,
Номер
19(1)
Опубликована: Янв. 22, 2025
Abstract
Chronic
obstructive
pulmonary
disease
(COPD)
is
induced
by
inhalation
of
toxic
substances
such
as
cigarettes
and
air
pollution.
Dry
powder
inhalers
(DPIs)
are
the
primary
treatment
for
these
diseases.
However,
they
have
some
problems,
residuals
in
a
capsule
caused
electrostatic
force
before
reaching
human
lungs.
This
study
investigated
particle
tribocharging
mechanism
DPI
using
tandem
differential
mobility
analyzer
(TDMA)
combined
discrete
element
method
computational
fluid
dynamics
(DEM-CFD)
approach.
In
TDMA
experiment,
charging
state
particles
changed
from
negative
to
positive
charge
device
fabricated
3D
printer.
because
particle–particle
collisions
particle–wall
collisions.
numerical
simulation,
occurred
more
frequently
than
Therefore,
change
device.
These
results
suggest
that
between
walls
cause
become
charged,
leading
decrease
their
deposition
deeper
regions
Moreover,
large
turbulence
kinetic
energy
airflow
were
widely
dispersed
optimum
necessary
reduce
aggregation
improve
delivery
efficiency
DPIs
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