Green Synthesis of Metal and Metal Oxide Nanoparticles: A Review of the Principles and Biomedical Applications

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(20), С. 15397 - 15397

Опубликована: Окт. 20, 2023

In recent years, interest in nanotechnology has increased exponentially due to enhanced progress and technological innovation. tissue engineering, the development of metallic nanoparticles been amplified, especially their antibacterial properties. Another important characteristic metal NPs is that they enable high control over features developed scaffolds (optimizing mechanical strength offering controlled release bioactive agents). Currently, main concern related method synthesis oxide environmental impact. The physical chemical uses toxic agents could generate hazards or exert carcinogenicity/environmental toxicity. Therefore, a greener, cleaner, more reliable approach needed. Green synthetic come as solution counter aforementioned limitations. Nowadays, green preferred because it leads prevention/minimization waste, reduction derivatives/pollution, use non-toxic (safer) solvents. This not only biomass sources reducing for salts. biomolecules also cover synthesized act situ capping agents. Further, involvement formation process reduces toxicity, prevents nanoparticle agglomeration, improves antimicrobial activity nanomaterial, leading possible synergistic effect. study aims provide comprehensive review nanoparticles, from routes, selected solvents, parameters latest application biomedical field.

Язык: Английский

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Recent Advances in the Additive Manufacturing of Stimuli‐Responsive Soft Polymers

Advanced Engineering Materials, Год журнала: 2023, Номер 25(21)

Опубликована: Авг. 29, 2023

Stimuli‐responsive polymers (SRPs) are special types of soft materials, which have been extensively used for developing flexible actuators, robots, wearable devices, sensors, self‐expanding structures, and biomedical thanks to their ability change shapes functional properties in response external stimuli including light, humidity, heat, pH, electric field, solvent, magnetic field or combinations two more these stimuli. In recent years, additive manufacturing (AM) aka 3D printing technology SRPs, also known as 4D printing, has gained phenomenal attention different engineering fields, its unique develop complex, personalized, innovative undergo twisting, elongating, swelling, rolling, shrinking, bending, spiraling, other complex morphological transformations. Herein, an effort made provide insightful information about the AM techniques, type applications including, but not limited tissue engineering, bionics, construction, smart textiles. This article incorporates current challenges prospects, hoping basis utilization this fields. It is expected that amalgamation with SRPs would unparalleled advantages arenas.

Язык: Английский

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Polylactic acid (PLA): Properties, synthesis, and biomedical applications – A review of the literature

Journal of Molecular Structure, Год журнала: 2024, Номер 1309, С. 138243 - 138243

Опубликована: Апрель 3, 2024

This comprehensive review is an in-depth analysis of polylactic acid (PLA), increasingly important biopolymer due to its wide-ranging applications and sustainability features. PLA's physical, thermal, mechanical properties are closely linked molecular distribution, mass, stereochemistry, allowing it exist in amorphous or semicrystalline states. The controlled polymerization different optical monomers enables the creation PLA variants with distinct properties. To address inherent hardness limitation, researchers exploring blends stereo complexes like PLLA/PDLA, leading enhanced thermal characteristics. moldability supports versatility various forms, from nanoparticles resorbable sutures. Focusing on composite materials, delves into reinforcement synthetic natural fibers, micro- nanoparticles. incorporation such as wood, cotton, carbon-based synthetics, significantly influences composite's Additionally, rise nanoscale fillers, including clays nanoparticles, has offered cost-effective solutions for material performance. Synthesis methods encompass direct polycondensation ring opening, latter preferred better control polymerization. Furthermore, highlights degradation behavior polymer which, together biocompatible eco-friendly production methods, makes a potential biological applications. innovative features, obtained by bibliometric map generated VosViewer software Scopus database, role biomedical field, particular tissue engineering improving healing rates and, well implants prosthetics.

Язык: Английский

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Chitosan-based nanofibrous scaffolds for biomedical and pharmaceutical applications: A comprehensive review

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 264, С. 130683 - 130683

Опубликована: Март 6, 2024

Язык: Английский

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Developing fibrin-based biomaterials/scaffolds in tissue engineering

Bioactive Materials, Год журнала: 2024, Номер 40, С. 597 - 623

Опубликована: Авг. 15, 2024

Tissue engineering technology has advanced rapidly in recent years, offering opportunities to construct biologically active tissues or organ substitutes repair even enhance the functions of diseased and organs. Tissue-engineered scaffolds rebuild extracellular microenvironment by mimicking matrix. Fibrin-based possess numerous advantages, including hemostasis, high biocompatibility, good degradability. Fibrin provide an initial matrix that facilitates cell migration, differentiation, proliferation, adhesion, also play a critical role cell-matrix interactions. are now widely recognized as key component tissue engineering, where they can facilitate defect repair. This review introduces properties fibrin, its composition, structure, biology. In addition, modification cross-linking modes fibrin discussed, along with various forms commonly used engineering. We describe biofunctionalization fibrin. provides detailed overview use applications skin, bone, nervous tissues, novel insights into future research directions for clinical treatment.

Язык: Английский

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Advancements in tissue engineering for cardiovascular health: a biomedical engineering perspective

Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12

Опубликована: Май 31, 2024

Myocardial infarction (MI) stands as a prominent contributor to global cardiovascular disease (CVD) mortality rates. Acute MI (AMI) can result in the loss of large number cardiomyocytes (CMs), which adult heart struggles replenish due its limited regenerative capacity. Consequently, this deficit CMs often precipitates severe complications such failure (HF), with whole transplantation remaining sole definitive treatment option, albeit constrained by inherent limitations. In response these challenges, integration bio-functional materials within cardiac tissue engineering has emerged groundbreaking approach significant potential for replacement. Bioengineering strategies entail fortifying or substituting biological tissues through orchestrated interplay cells, methodologies, and innovative materials. Biomaterial scaffolds, crucial paradigm, provide essential microenvironment conducive assembly functional encapsulating contracting cells. Indeed, field witnessed remarkable strides, largely owing application biomaterial scaffolds. However, complexities persist, necessitating further exploration innovation. This review delves into pivotal role scaffolds engineering, shedding light on their utilization, challenges encountered, promising avenues future advancement. By critically examining current landscape, we aim catalyze progress toward more effective solutions regeneration ultimately, improved outcomes patients grappling ailments.

Язык: Английский

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Hydrogels: Classifications, fundamental properties, applications, and scopes in recent advances in tissue engineering and regenerative medicine – A comprehensive review

Arabian Journal of Chemistry, Год журнала: 2024, Номер 17(10), С. 105968 - 105968

Опубликована: Авг. 17, 2024

Hydrogels are three-dimensional structures that serve as substitutes for the extracellular matrix (ECM) and possess outstanding physicochemical biochemical characteristics. They gaining importance in regenerative medicine because of their similarity to natural terms moisture content wound tissue healing permeability. Tissue engineering advancements have resulted development flexible hydrogels mimic dynamic characteristics ECM. Several approaches been applied produce from biopolymers with enhanced functional structural different applications (TERM). This review provides a comprehensive overview hydrogel healing, engineering, drug delivery systems. We outline types based on physical chemical crosslinking, fundamental properties, TERM. article provided recent literature within five years. Recent developments biopolymer-based state-of-the-art discussed, emphasizing significant challenges future perspectives.

Язык: Английский

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Nanotechnology development in surgical applications: recent trends and developments

European journal of medical research, Год журнала: 2023, Номер 28(1)

Опубликована: Ноя. 24, 2023

Abstract This paper gives a detailed analysis of nanotechnology's rising involvement in numerous surgical fields. We investigate the use nanotechnology orthopedic surgery, neurosurgery, plastic oncology, heart vascular ophthalmic thoracic and minimally invasive surgery. The details how helps with arthroplasty, chondrogenesis, tissue regeneration, wound healing, more. It also discusses employment nanomaterials implant surfaces, bone grafting, breast implants, among other things. article explores various uses, including stem cell-incorporated nano scaffolds, nano-surgery, hemostasis, nerve nanorobots, diagnostic applications. ethical safety implications using surgery are addressed. future possibilities investigated, pointing to possible route for improved patient outcomes. essay finishes comment on transformational influence applications its promise breakthroughs. Graphical

Язык: Английский

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Shaping the Future of Cardiovascular Disease by 3D Printing Applications in Stent Technology and its Clinical Outcomes

Current Problems in Cardiology, Год журнала: 2023, Номер 49(1), С. 102039 - 102039

Опубликована: Авг. 19, 2023

Язык: Английский

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Composite patch with negative Poisson's ratio mimicking cardiac mechanical properties: Design, experiment and simulation

Materials Today Bio, Год журнала: 2024, Номер 26, С. 101098 - 101098

Опубликована: Май 22, 2024

Developing patches that effectively merge intrinsic deformation characteristics of cardiac with superior tunable mechanical properties remains a crucial biomedical pursuit. Currently used traditional block-shaped or mesh patches, typically incorporating positive Poisson's ratio, often fall short matching the tissue satisfactorily, thus diminishing their repairing capability. By introducing auxeticity into this study is trying to present beneficial approach address these shortcomings patches. The featuring auxetic effect, offer unparalleled conformity complex challenges. Initially, scaffolds demonstrating effect were designed by merging chiral rotation and concave angle units, followed integrating composite hydrogel through thermally triggering, ensuring excellent biocompatibility closely mirroring heart tissue. Tensile tests revealed possessed elasticity strain capacity exceeding tissue's physiological activity. Notably, Model III showed an equivalent modulus ratio toward tissue, underscoring its outstanding potential as Cyclic tensile loading demonstrated withstood continuous heartbeats, showcasing cyclic recovery capabilities. Numerical simulations further elucidated failure mechanisms leading exploration influence on alternative design parameters, which enabled customization strength ratio. Therefore, research presents substantial for designing can emulate possess adjustable parameters.

Язык: Английский

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