Chemical Engineering Journal, Год журнала: 2024, Номер 497, С. 154506 - 154506
Опубликована: Авг. 3, 2024
Язык: Английский
Journal of Hematology & Oncology, Год журнала: 2024, Номер 17(1)
Опубликована: Апрель 2, 2024
Abstract Cancer immunotherapy and vaccine development have significantly improved the fight against cancers. Despite these advancements, challenges remain, particularly in clinical delivery of immunomodulatory compounds. The tumor microenvironment (TME), comprising macrophages, fibroblasts, immune cells, plays a crucial role response modulation. Nanoparticles, engineered to reshape TME, shown promising results enhancing by facilitating targeted These nanoparticles can suppress fibroblast activation, promote M1 macrophage polarization, aid dendritic cell maturation, encourage T infiltration. Biomimetic further enhance increasing internalization agents cells such as cells. Moreover, exosomes, whether naturally secreted body or bioengineered, been explored regulate TME immune-related affect cancer immunotherapy. Stimuli-responsive nanocarriers, activated pH, redox, light conditions, exhibit potential accelerate co-application with checkpoint inhibitors is an emerging strategy boost anti-tumor immunity. With their ability induce long-term immunity, nanoarchitectures are structures development. This review underscores critical overcoming current driving advancement modification.
Язык: Английский
Процитировано
161
Coordination Chemistry Reviews, Год журнала: 2024, Номер 508, С. 215773 - 215773
Опубликована: Март 14, 2024
Phototherapy, using light as a therapeutic modality, has been widely applied in treating various diseases, especially cancer. This approach is valued for its non-invasive nature and minimal risk of drug resistance. However, phototherapy faces challenges such the undesired delivery phototherapeutic agents, potential phototoxicity, limited penetration into tissues. Lanthanide-doped nanoparticles offer attractive opportunities to improve efficacy photodynamic therapy. These are distinguished by their unique optical properties, excellent photostability against blinking bleaching effects, large Stokes or anti-Stokes shifts, sharp emission peaks, long luminescence lifetimes. In addition, lanthanide-doped can be excited near-infrared (NIR) X-rays, enabling deep-tissue penetration. Beyond use photosensitizers, nanoparticle surfaces easily modified with targeting ligands, chemical drugs, functional molecules enhance effectiveness enable combination this review, we organize lanthanide-based tumor six main domains: therapy, photothermal X-ray-based light-controlled photoimmunotherapy, other innovative treatments that regulated light. We introduce basic principles characteristics lanthanide nanoparticles. Following this, summarize latest advances utilizing phototherapy, focusing on design principles, mechanisms action, cancer treatment. To conclude, address existing explore future within area research.
Язык: Английский
Процитировано
24
Chemical Society Reviews, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
This review provides a comprehensive summary of the dysregulation redox metabolism in cancer cells and advantages latest advances nanomaterial-assisted metabolic regulation therapy.
Язык: Английский
Процитировано
12
Coordination Chemistry Reviews, Год журнала: 2025, Номер 536, С. 216642 - 216642
Опубликована: Апрель 5, 2025
Язык: Английский
Процитировано
1
Cancer Biology & Therapy, Год журнала: 2024, Номер 25(1)
Опубликована: Май 20, 2024
The tumor microenvironment (TME) plays an essential role in cell survival by profoundly influencing their proliferation, metastasis, immune evasion, and resistance to treatment. Extracellular vesicles (EVs) are small particles released all types often reflect the state of parental cells modulate other cells' functions through various cargo they transport. Tumor-derived EVs (TDSEVs) can transport specific proteins, nucleic acids lipids tailored propagate signals establish a favorable TME. Thus, TME's biological characteristics affect TDSEV heterogeneity, this interplay amplify growth, dissemination, therapy. This review discusses between TME TDSEVs based on summarizes strategies for targeting cancer cells. Additionally, it reviews current issues challenges field offer fresh insights into comprehending development mechanisms exploring innovative clinical applications.
Язык: Английский
Процитировано
9
Nanoscale, Год журнала: 2024, Номер 16(18), С. 8708 - 8738
Опубликована: Янв. 1, 2024
Cancer immunotherapy, a burgeoning modality for cancer treatment, operates by activating the autoimmune system to impede growth of malignant cells. Although numerous immunotherapy strategies have been employed in clinical therapy, resistance cells immunotherapeutic medications and other apprehensions attainment sustained advantages most patients. Recent advancements nanotechnology drug delivery hold promise augmenting efficacy immunotherapy. However, is currently constrained inadequate specificity delivery, low rate response, intricate immunosuppressive tumor microenvironment. In this context, investigation cell membrane coated nanoparticles (CMNPs) has revealed their ability perform targeted immune evasion, controlled release, immunomodulation. By combining advantageous features natural membranes nanoparticles, CMNPs demonstrated unique potential realm This review aims emphasize recent research progress elucidate underlying mechanisms as an innovative platform enhancing Additionally, it provides comprehensive overview current involving different types CMNPs, with intention further exploration optimization.
Язык: Английский
Процитировано
8
Journal of Controlled Release, Год журнала: 2024, Номер 372, С. 587 - 608
Опубликована: Июнь 29, 2024
Язык: Английский
Процитировано
7
Molecular Pharmaceutics, Год журнала: 2025, Номер unknown
Опубликована: Янв. 17, 2025
Malignant tumors pose a considerable threat to human life and health. Traditional treatments, such as radiotherapy chemotherapy, often lack specificity, leading collateral damage normal tissues. Tumor microenvironment (TME) is characterized by hypoxia, acidity, redox imbalances, elevated ATP levels factors that collectively promote tumor growth metastasis. This review provides comprehensive overview of the nanoparticles developed in recent years for TME-responsive strategies or TME-modulating methods therapy. The focus on designing synthesizing can interact with achieve precisely controlled drug release. These activate release under specific conditions within environment, thereby enhancing efficacy drugs while reducing toxicity cells. Moreover, simply eliminating cells does not fundamentally solve problem. Only comprehensively regulating TME make it unsuitable cell survival proliferation we more thorough therapeutic effects reduce risk recurrence. regulation aim suppress metastasis modulating various components TME. only improve treatment outcomes but also have potential lay foundation future personalized cancer therapies.
Язык: Английский
Процитировано
1
Heliyon, Год журнала: 2024, Номер 10(18), С. e37217 - e37217
Опубликована: Авг. 30, 2024
Язык: Английский
Процитировано
6
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Окт. 6, 2024
Inspired by the concept of "natural camouflage," biomimetic drug delivery systems have emerged to address limitations traditional synthetic nanocarriers, such as poor targeting, susceptibility identification and clearance, inadequate biocompatibility, low permeability, systemic toxicity. Biomimetic nanocarriers retain proteins, nucleic acids, other components parent cells. They not only facilitate but also serve communication media inhibit tumor This paper delves into mechanisms between various cell-derived cells, microenvironment, well their applications in delivery. In addition, additional capabilities conferred on modified targeting environmental responsiveness, are outlined. Finally, we propose future development directions for hoping inspire researchers design efforts ultimately achieve clinical translation.
Язык: Английский
Процитировано
5