Journal of Education Health and Sport,
Год журнала:
2024,
Номер
62, С. 30 - 45
Опубликована: Фев. 21, 2024
Introduction
Exosomes
are
small,
membrane-bound
extracellular
vesicles
that
play
a
pivotal
role
in
intercellular
communication.
have
garnered
significant
interest
regenerative
medicine
due
to
their
unique
properties
support
tissue
repair,
regeneration,
and
healing.
These
crucial
communication,
potential
makes
them
promising
tools
the
field
of
medicine.
Purpose
study
This
review
aims
present
exosomes
clinical
applications
many
fields
The
main
aim
is
as
substance
restores
health,
youth
vitality.
Material
method
Literature
was
primarily
based
on
scientific
materials,
English
Polish
databases
original
research.
following
keywords
its
equivalents
were
used
search
Google
Scholar
PubMed:
“
exosomes",
“regenerative
medicine”,
“stem
cells”.
Cell Death Discovery,
Год журнала:
2024,
Номер
10(1)
Опубликована: Май 2, 2024
Abstract
The
escalating
threat
of
bone-related
diseases
poses
a
significant
challenge
to
human
health.
Mesenchymal
stem
cell
(MSC)-derived
extracellular
vesicles
(MSC-EVs),
as
inherent
cell-secreted
natural
products,
have
emerged
promising
treatments
for
diseases.
Leveraging
outstanding
features
such
high
biocompatibility,
low
immunogenicity,
superior
biological
barrier
penetration,
and
extended
circulating
half-life,
MSC-EVs
serve
potent
carriers
microRNAs
(miRNAs),
long
no-code
RNAs
(lncRNAs),
other
biomolecules.
These
cargo
molecules
play
pivotal
roles
in
orchestrating
bone
metabolism
vascularity
through
diverse
mechanisms,
thereby
contributing
the
amelioration
Additionally,
engineering
modifications
enhance
bone-targeting
ability
MSC-EVs,
mitigating
systemic
side
effects
bolstering
their
clinical
translational
potential.
This
review
comprehensively
explores
mechanisms
which
regulate
disease
progression.
It
delves
into
therapeutic
potential
adept
drug
carriers,
augmented
by
engineered
modification
strategies
tailored
osteoarthritis
(OA),
rheumatoid
arthritis
(RA),
osteoporosis,
osteosarcoma.
In
conclusion,
exceptional
promise
exhibited
positions
them
an
excellent
solution
with
considerable
applications
orthopedics.
Frontiers in Oncology,
Год журнала:
2024,
Номер
14
Опубликована: Март 26, 2024
The
discovery
and
use
of
exosomes
ushered
in
a
new
era
cell-free
therapy.
Exosomes
are
subgroup
extracellular
vesicles
that
show
great
potential
disease
treatment.
Engineered
exosomes.
with
their
improved
functions
have
attracted
intense
interests
application
translational
medicine
research.
However,
the
technology
engineering
still
faces
many
challenges
which
been
limitation
for
clinical
application.
This
review
summarizes
current
status
research
on
engineered
difficulties
encountered
recent
years,
view
to
providing
approaches
ideas
future
exosome
modification
drug
development.
Current Osteoporosis Reports,
Год журнала:
2024,
Номер
22(2), С. 257 - 265
Опубликована: Март 1, 2024
The
present
review
will
highlight
recent
reports
supporting
the
relevance
of
extracellular
vesicles
to
musculoskeletal
system
in
health
and
disease.
Preserving
is
important
maintain
a
good
quality
life,
bone-muscle
crosstalk
crucial
this
regard.
This
latter
largely
mediated
by
released
different
cell
populations
residing
muscle
bone,
which
deliver
cargoes,
microRNAs,
proteins
being
most
relevant
ones,
target
cells.
Extracellular
could
be
exploited
as
therapeutic
tools,
view
their
resistance
destruction
biological
fluid
possibility
functionalized
according
need.
are
recognized
players
cross-talk.
Additional
studies
however
required
refine
use
biomarkers
early
alterations
system,
potential
tools.
Orthopaedic Surgery,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 25, 2025
Diagnostic
imaging
in
sports
medicine
includes
traditional
modalities
such
as
x-ray,
computed
tomography
(CT),
and
magnetic
resonance
(MRI).
Despite
having
certain
advantages,
these
techniques
often
have
lower
sensitivity
specificity,
making
it
difficult
to
detect
soft
tissue
injuries
early-stage
cartilage
damage.
They
also
lack
the
ability
assess
biomechanical
properties
functional
states
of
tissues.
Photoacoustic
(PAI)
offers
a
powerful,
non-ionizing,
cost-effective
alternative
diagnosis
therapeutic
monitoring
injuries.
PAI
combines
benefits
optical
ultrasound
provide
high-resolution
images
deep
tissues,
including
tendons
ligaments.
This
technology
uses
pulsed
lasers
irradiate
causing
thermal
expansion
generating
waves,
which
are
then
captured
converted
into
images.
is
particularly
adept
at
depicting
blood
vessels
tissues
with
high
resolution
absorption
contrasts
oxy-
deoxyhemoglobin.
It
can
oxygenation
metabolic
activities,
crucial
for
evaluating
healing
process
Herein,
role
assessed
its
advantages
over
methods
x-rays,
CT
scans,
MRI
scans
diagnosing
musculoskeletal
Molecules,
Год журнала:
2025,
Номер
30(7), С. 1631 - 1631
Опубликована: Апрель 6, 2025
Rapid
functional
soft
tissue
restoration
has
shown
considerable
promise
as
a
framework
for
stability
and
coordination
in
the
human
body.
Inspired
by
anisotropic
arrangement
of
structures
with
hard
phases
biological
tissues,
such
tendon,
cartilage,
ligament,
many
methods
have
been
used
to
fabricate
composite
hydrogels
appropriate
mechanical
properties.
The
development
high-strength
hydrogel
strong
bioactivity
remains
key
barrier
replace
tissues
comparable
synthetic
structures.
In
this
study,
highly
dispersed
hydroxyapatite
nanofiber
(HANF)
reinforced
polyvinyl
alcohol-sodium
alginate
(PVA/SA)
is
prepared
replacement.
effect
addition
HANF
on
microstructure
properties
also
investigated.
results
show
that
PVA/SA
hydrogel,
after
incorporation
HANF,
combines
well
(HANF@PVA/SA).
SEM
morphologies
can
enter
holes
three-dimensional
structure
hydrogel.
Additionally,
enhance
compressive
strength
from
4.66
MPa
7.72
MPa.
At
same
time,
HANF@PVA/SA
maintains
excellent
hydrophilicity
original
Finally,
cytotoxicity
live/dead
cell
staining
tests
confirmed
its
biocompatibility,
demonstrating
tremendous
potential
use
repair.
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 27, 2025
Abstract
Given
the
electrical
signal
transduction
capability
and
excellent
biocompatibility,
conductive
hydrogels
are
regarded
as
ideal
candidates
for
high‐performance
strain/pressure
sensors
applied
in
personalized
medicine.
However,
there
challenges
concurrent
attainment
of
flexible
hydrogel‐based
with
remarkable
conductivity,
sensitivity,
reliable
stability.
Herein,
a
synergistic
strategy
based
on
hole–bridge
structure
molecular‐crowding
effect
is
proposed
to
fabricate
multifunctional
sensor.
As‐prepared
eutectic
hydrogel
displays
comprehensive
performances
impressive
conductivity
(2.81
S
m
−1
),
boosted
mechanical
robustness
(a
tensile
strength
2.95
MPa),
environmental
tolerance
(≈79.8%
water
retention
at
50
°C
20
days;
frost
resistance
=
−45.3
°C).
Notably,
hydrogel‐derived
stretchable
sensor
effective
antibacterial
ability
exhibits
enhanced
sensitivity
(gauge
factor
4.49)
across
wide
linear
range,
supporting
monitoring
joint
movement
electrocardiographic
signals,
along
on‐demand
photothermal
treatment.
As
demonstration,
employment
efficiently
conveying
information
high‐fidelity
handwriting
recognition
investigated
assistance
machine
learning.
This
innovative
holds
high
promise
future
applications
wearable‐smart
devices
integrated
wireless
transmission
modules,
exhibiting
great
potential
personal
rehabilitation
training
healthcare
monitoring.
The Innovation Medicine,
Год журнала:
2025,
Номер
unknown, С. 100132 - 100132
Опубликована: Янв. 1, 2025
<p>Sports
injuries
are
one
of
the
most
common
diseases,
and
repair
regeneration
joint
soft
tissues
(ligaments,
tendons,
cartilage,
etc.)
involved
in
them
challenging.
Traditional
treatment
strategies,
such
as
drugs,
physical
therapy,
surgery,
difficult
to
achieve
tissue
reconstruction
natural
physiological
functions.
Regenerative
medicine
offers
promising
solutions,
including
biotherapy,
engineering,
prosthesis
or
organ
transplantation.
These
approaches
aim
regenerate
damaged
tissues,
reduce
recovery
time,
improve
functional
outcomes.
Stem
cells
from
different
sources
their
constructed
organoids,
novel
biomaterials,
3D
printing
other
innovative
technologies
have
been
used.
Individual
variability,
uncertain
long-term
efficacy,
high
costs
remain
obstacles
for
clinical
application.
Further
research
is
needed
explore
molecular
mechanisms
underlying
regenerative
therapies
orchestrate
biological,
chemical
factors.</p>
