Topics in medicinal chemistry, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Язык: Английский
Nanomedicine, Год журнала: 2025, Номер unknown, С. 1 - 18
Опубликована: Янв. 31, 2025
Advancements in tissue regeneration, particularly bone regeneration is key area of research due to potential novel therapeutic approaches. Efforts reduce reliance on autologous and allogeneic grafts have led the development biomaterials that promote synchronized controlled healing. However, use growth factors limited by their short half-life, slow penetration, large molecular size toxicity. These suggest traditional delivery methods may be inadequate hence, address these challenges, new strategies are being explored. approaches include bioactive substances within advanced systems enable precise spatiotemporal control. Dual-release composite scaffolds offer a promising solution reducing need for multiple surgical interventions simplifying treatment process. allow sustained drug release, enhancing repair while minimizing drawbacks conventional methods. This review explores various dual-drug release systems, discussing modes action, types drugs used mechanisms improve regeneration.
Язык: Английский
Процитировано
0
Regenerative Therapy, Год журнала: 2025, Номер 28, С. 558 - 572
Опубликована: Фев. 13, 2025
Язык: Английский
Процитировано
0
Pharmaceutics, Год журнала: 2025, Номер 17(4), С. 453 - 453
Опубликована: Апрель 1, 2025
Background/Objectives: This study aimed to explore the therapeutic potential of umbilical mesenchymal stem cell-derived apoptotic vesicles (UMSC-apoVs) in a 5-Fluorouracil (5-FU)-induced impairment skin wound healing. Methods: UMSC-apoVs were isolated from UMSCs using differential centrifugation after induction apoptosis. A murine model was established by administering 5-FU via intravenous tail injection, followed full-thickness creation. Mice received local injections at lesion site. Wound healing evaluated based on closure rates, histological analysis, and vivo/in vitro functional assays. Rotenone (Rot)-pretreated used role mitochondrial transfer between cells (SMSCs) Results: significantly accelerated 5-FU-treated mice, as demonstrated enhanced rates findings reduced inflammatory infiltration increased collagen deposition. transferred mitochondria SMSCs, enhancing viability, proliferation, migration while reducing reactive oxygen species (ROS) production SMSCs. Rot pretreatment inhibited effects inducing dysfunction UMSC-apoVs. Conclusions: Our indicate that improve 5-FU-induced impaired facilitating transfer, suggesting novel strategy for alleviating chemotherapy-induced
Язык: Английский
Процитировано
0
Regenerative Therapy, Год журнала: 2025, Номер 29, С. 303 - 318
Опубликована: Апрель 5, 2025
Язык: Английский
Процитировано
0
Journal of Orthopaedic Translation, Год журнала: 2025, Номер 52, С. 85 - 96
Опубликована: Апрель 11, 2025
Язык: Английский
Процитировано
0
International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125592 - 125592
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Medicine, Год журнала: 2024, Номер 11
Опубликована: Сен. 5, 2024
Observational studies have indicated a potential association between autoimmune diseases and the occurrence of Osteoarthritis (OA), with an increased risk mortality among affected patients. However, whether causal relationship exists two remains unknown.
Язык: Английский
Процитировано
0
Biomedicines, Год журнала: 2024, Номер 12(11), С. 2478 - 2478
Опубликована: Окт. 28, 2024
Background/Objectives: Osteoarthritis (OA) is a prevalent and debilitating joint disorder characterized by progressive cartilage degradation inflammation, for which traditional treatments offer only symptomatic relief without halting disease progression. Exosomes, cell-free vesicles derived from mesenchymal stem cells, have emerged as promising alternative therapy owing to their regenerative anti-inflammatory properties. Methods: This review synthesizes findings recent studies (2017–2023) on the therapeutic potential of exosomes in OA treatment, highlighting ability modulate microenvironment, reduce promote repair delivering bioactive molecules such cytokines, growth factors, regulatory ribonucleic acids. Results: We explore integration with biomaterials, hydrogels scaffolds, enhance delivery efficacy, we address critical challenges associated clinical application, including standardization isolation characterization methods, scalability production, mechanistic understanding, long-term safety. Despite these challenges, exosome-based therapies several advantages over cell-based treatments, lower immunogenicity, ease handling, targeted agents damaged tissues. Conclusions: provide an analytical perspective current state exosome research OA, emphasizing need standardized production deeper insights, rigorous safety assessments. Future directions should focus optimizing systems, exploring personalized medicine approaches, conducting comparative effectiveness fully realize treatment. Addressing gaps will be crucial translating bench bedside achieving transformative impact management.
Язык: Английский
Процитировано
0
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Ноя. 18, 2024
Extracellular vesicles (EV) can be produced as part of pathology and physiology with increased amounts in pathological conditions. EVs carry transfer cargo such proteins, nucleic acids, lipids to target cells mediate intercellular communication resulting modulation gene expression, signaling pathways, phenotype recipient cells. greatly influence the extracellular environment immune response. Their immunomodulatory properties are crucial rheumatoid arthritis (RA), a condition marked by dysregulated modulate functions innate adaptive RA pathogenesis. Differentially expressed EV-associated molecules RA, microRNAs (miRNAs), long-noncoding RNAs (lncRNAs), messenger (mRNAs) proteins promising markers diagnose disease. miRNA, lncRNA, circular RNA (circRNA) cargos EV regulate inflammation pathogenic fibroblast-like synoviocytes (RA-FLS). Downregulated tissue drugs encapsulated for therapy. This review provides an updated overview EVs’ immunomodulatory, diagnostic, therapeutic roles, particularly emphasizing mesenchymal stem cell-derived (MSC-EVs).
Язык: Английский
Процитировано
0
Topics in medicinal chemistry, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0