Hacettepe University Journal of the Faculty of Pharmacy,
Год журнала:
2023,
Номер
unknown
Опубликована: Дек. 21, 2023
TürkçeNörodejeneratif
hastalıklar
arasında
kompleks
bir
immünopatolojiye
sahip
olan
Multipl
Skleroz
(MS)’un
tedavisinde
birçok
faktörün
dikkate
alınması
gerekmektedir.
Bu
çok
faktörlü
hastalıktaki
klinik
bulgular
miyelin
kaybının
ilerlemesine,
enflamasyonun
evresine,
aksonların
durumuna
ve
oligodendrosit
öncü
hücrelerinin
aktivitesine
bağlıdır.
Uzun
yıllardır
süregelen
yoğun
çalışmalara
rağmen
hastalığın
oluşu
kan-beyin
engeli
(KBE)
gibi
ilaçların
beyne
ulaşmasını
engelleyen
yapılar
nedeniyle
henüz
kesin
tedavi
bulunamamıştır.
durum,
bilim
insanlarını
yeni
yaklaşımlar
aramaya
yönlendirmiştir.
Yapılan
araştırmalarda
genellikle
nanotaşıyıcı
olarak
adlandırılan
nano
boyuttaki
farmasötik
taşıyıcıların
MS’nin
yalnızca
teşhisinde
değil
aynı
zamanda
de
rol
üstlenebileceğini
göstermiştir.
tedavisi
için
öncesi
in
vitro
vivo
çalışmalarla
başarılı
olduğu
gösterilen
bu
sistemlerin
uygulamaya
geçiş
yapabilmesi
çalışmalar
şekilde
devam
etmektedir.
derlemede
MS
tedavisine
yönelik
nanotaşıyıcılar
konusunda
literatürde
yer
alan
en
güncel
gelişmeler
değerlendirilmiştir.
Materials Today Bio,
Год журнала:
2025,
Номер
31, С. 101457 - 101457
Опубликована: Янв. 5, 2025
Central
nervous
system
(CNS)
diseases
are
a
major
cause
of
disability
and
death
worldwide.
Due
to
the
blood-brain
barrier
(BBB),
drug
delivery
for
CNS
is
extremely
challenging.
Nano-delivery
systems
can
overcome
limitations
BBB
deliver
drugs
CNS,
improve
ability
target
brain
provide
potential
therapeutic
methods
diseases.
At
same
time,
choice
different
(bypassing
or
crossing
BBB)
further
optimize
effect
nano-drug
system.
This
article
reviews
nano-delivery
way
enters
brain.
Different
kinds
nanoparticles
were
discussed
in
depth.
International Journal of Pharmaceutics,
Год журнала:
2024,
Номер
659, С. 124216 - 124216
Опубликована: Май 10, 2024
The
nasal
administration
route
has
been
studied
for
the
delivery
of
active
molecules
directed
to
Central
Nervous
System,
thanks
anatomical
connection
between
cavity
and
brain.
Dimethyl
fumarate
is
used
treat
relapsing-remitting
multiple
sclerosis,
with
a
role
as
an
immunomodulator
towards
T-
T-cells
cytoprotector
neurons
glial
cells.
Its
use
in
therapy
hindered
by
its
low
aqueous
solubility,
stability,
due
hydrolysis
sublimation
at
room
temperature.
To
overcome
this
limitation,
study
we
evaluated
feasibility
using
two
amorphous
β-cyclodextrin
derivatives,
namely
hydroxypropyl
methyl
β-cyclodextrin,
obtain
nasally
administrable
powder
view
nose-to-brain
administration.
Initially,
interaction
product
was
different
analytical
methods
(differential
scanning
calorimetry,
Fourier
transform
infrared
spectroscopy
X-ray
diffraction)
detect
occurrence
binary
formation,
while
phase
solubility
analysis
probe
complexation
solution.
dimethyl
fumarate-cyclodextrin
showing
best
stability
properties
subsequently
development
chitosan-based
mucoadhesive
comparing
preparative
methods.
performance
terms
both
hydrolytic
DMF
recovery
achieved
obtained
via
freeze-drying.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(19), С. 10834 - 10834
Опубликована: Окт. 9, 2024
Cyclodextrins
(CDs)
are
ubiquitous
excipients,
constituted
of
cyclic
glucopyranose
units,
and
possess
a
unique
dual
nature,
that
hydrophobic
interior
hydrophilic
exterior.
This
enables
their
interaction
with
lipid-affinitive
compounds
compounds,
thereby
augmenting
application
in
pharmaceutical
formulations
as
agents
for
improving
solubility,
well
fundamental
elements
advanced
drug
delivery
systems.
Additionally,
CDs,
upon
suitable
modification,
can
strategically
participate
the
cellular
components
physical
barriers,
such
blood–brain
barrier,
where
intricate
multifunctional
engagement
leads
to
various
biological
impacts.
review
consolidates
crucial
features
CDs
derivatives,
summarizes
applications
them
systems
neurodegenerative
disorders,
emphasizing
notable
potentials.
Laboratory Animals,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 29, 2024
The
intranasal
route
enables
direct
delivery
of
multiple
substances
from
the
nose
to
brain,
through
olfactory
and
trigeminal
pathways,
bypassing
blood-brain
barrier
avoiding
systemic
absorption.
Despite
potential
this
route,
various
administration
approaches
make
data
reproducibility
interpretation
challenging,
emphasizing
necessity
establish
a
consistent
methodology.
Considering
this,
aim
our
study
was
assess
compare
distribution
two
dye
volumes
(30
µl
50
µl)
in
nasal
cavity
rat
cadavers.
We
employed
three
distinct
methods
delivery:
drops,
by
pipette
tip,
or
cannula
inserted
into
cavity.
results
indicated
that
for
both
volumes,
using
drops
tip
methods,
dispersion
occurred
mainly
vestibule,
respiratory
regions,
without
reaching
bulbs.
Using
method,
deposition
predominantly
with
66.7%
100%
bulbs,
respectively,
low
high
volume.
Furthermore,
demonstrated
differences
between
pharynx,
larynx,
trachea,
septal
window,
incisive
papilla,
where
an
increased
presence
observed
instillation
across
all
methods.
According
results,
most
effective
method
region.
However,
further
studies
live
animals
will
be
necessary
determine
refine
consistently
allows
specific
system.
