Journal of Controlled Release, Год журнала: 2024, Номер 377, С. 324 - 338
Опубликована: Ноя. 23, 2024
Язык: Английский
Journal of Controlled Release, Год журнала: 2025, Номер unknown, С. 113829 - 113829
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0
Advanced Materials, Год журнала: 2025, Номер unknown
Опубликована: Май 20, 2025
Abstract Spinal cord injury (SCI) is a complex and dynamic pathological condition characterized by disrupted lipid metabolism neuroinflammatory responses, posing significant therapeutic challenges. To address these, biomimetic bacterial outer membrane nanoparticles (BM‐NPs) are designed integrating the precise targeting capability of detoxified vesicles (dOMVs) with efficient drug‐loading properties liposomes. BM‐NPs exhibit superior efficiency toward peripheral neutrophils macrophages, enabling spatiotemporal drug delivery via immune cells. An innovative “Tortoise Hare” adaptive strategy introduced, where facilitate rapid transport during acute phase SCI, while macrophages ensure sustained subacute phase. This aligns progression offering precision tailored to different stages injury. demonstrate multifaceted effects, including suppression foam cell formation through coordinated enhancement droplet autophagy cholesterol efflux. Furthermore, they modulate inflammatory microenvironment, preserve myelin integrity, significantly promote neural functional recovery post‐SCI. By overcoming limitations conventional systems in timeliness, offer an innovative, highly efficient, clinically translatable platform for SCI treatment other disorders central nervous system.
Язык: Английский
Процитировано
0
Pharmacological Research, Год журнала: 2025, Номер 217, С. 107803 - 107803
Опубликована: Май 27, 2025
Язык: Английский
Процитировано
0
Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер unknown, С. 114844 - 114844
Опубликована: Июнь 1, 2025
Язык: Английский
Процитировано
0
Journal of Inflammation Research, Год журнала: 2024, Номер Volume 17, С. 4297 - 4308
Опубликована: Июль 1, 2024
Purpose: To evaluate the prognostic significance of platelet distribution width-to-lymphocyte ratio (PDWLR) in patients with locoregionally advanced nasopharyngeal carcinoma (LA-NPC). Moreover, a nomogram based on PDWLR was built and validated to predict overall survival (OS) this population. Patients Methods: All LA-NPC who were diagnosed treated between January 2015 December 2017 at Guangxi Medical University Cancer Hospital included. Cox regression analyses performed assess clinical features that might affect OS screen for independent predictors. The predictors important variables used build validate predicting OS. Then, capability model estimated by discrimination, calibration usefulness. Risk stratification conducted using nomogram-calculated risk score, comparison high-risk group low-risk through Kaplan–Meier method. Results: This study included 746 patients. Multivariate analysis suggested age (hazard [HR]: 1.81, 95% confidence interval [CI]: 1.18– 2.78, P = 0.007), gender (HR: 2.03, CI: 1.12– 3.68, 0.019), pre-treatment plasma Epstein–Barr virus (EBV) DNA 1.55, 1.01– 2.39, 0.047), 2.61, 1.67– 4.09, < 0.001) Compared 8th edition TNM staging system, above four factors (T stage N stage) demonstrated better predictive performance. had ability identify individuals high risk. Conclusion: promising negative predictor LA-NPC. performance than current system. Keywords: nomogram, ratio, inflammatory biomarker, carcinoma,
Язык: Английский
Процитировано
1
Aggregate, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 15, 2024
ABSTRACT While nanomedicine research shows a great progress in the treatment of cancer, it still faces challenges tumor recurrence and metastasis. Numerous studies have demonstrated intricate crosstalk between platelets cells. The re‐education by cells enables these to provide critical assistance for proliferation, recurrence, Engineered shown promising potential tumors, postoperative Different engineering technologies such as surface modification, gene editing, membrane coating, loading into hydrogels can produce multifunctional customized engineered platelets. These inherit key properties platelets, including long blood circulation, targeting, thrombus be stimulated generate derivatized particles. In this review, we elucidate role complex processes tumorigenesis progression summarize emerging paradigm therapy. purpose review is comprehensively explore value toward clinical providing valuable reference further development their broader applications field cancer
Язык: Английский
Процитировано
1
Analytical Chemistry, Год журнала: 2024, Номер 96(28), С. 11205 - 11215
Опубликована: Июль 5, 2024
Lipid nanoparticles (LNPs) are emerging as one of the most promising drug delivery systems. The long-circulating effect intact LNPs (i-LNPs) is key to efficacy and toxicity in vivo. However, significant challenge specific sensitive detection i-LNPs. Herein, a dual-recognition fluorescence enzyme-linked immunosorbent assay (DR-FELISA) was developed directly isolate detect i-LNPs by combining separation with one-step signal amplification strategy. microplates captured enriched through antibody–antigen reaction. Dual-chol probes were spontaneously introduced into lipid bilayer i-LNPs, converting double-cholesterol probes. Finally, end dual-chol initiated localized scaffolding autocatalytic DNA circuits (SADC) system for further amplification. SADC provides efficient amplifier network structures self-assembled triggers. Simultaneous recognition surface PEG-lipid significantly eliminates interference from biological samples. detected high selectivity, ranging 0.2 1.25 mg/mL limit 0.1 mg/mL. Moreover, this method allows isolation quantitative analysis different formulations serum samples satisfactory recovery rate 94.8 116.3%. Thus, DR-FELISA an advanced platform exclusive providing new insights study quality intracorporal process complex formulations.
Язык: Английский
Процитировано
0
ACS Nano, Год журнала: 2024, Номер 18(43), С. 29421 - 29438
Опубликована: Окт. 15, 2024
Over the past decade, a marked escalation in prevalence of hepatic pathologies has been observed, adversely impacting quality life for many. The predominant therapeutic strategy liver diseases pharmacological intervention; however, its efficacy is often constrained. Currently, liposomes are tiny structures that can deliver drugs directly to targeted areas, enhancing their effectiveness. Specifically, cell membrane-associated have gained significant attention. Despite this, there still much learn about binding mechanism this type liposome. Thus, review comprehensively summarizes relevant information on liposomes, including clinical applications and future development directions. First, we will briefly introduce composition types liposomes. We provide an overview structure discuss various associated with membranes. Second, thoroughly strategies drug delivery using these Lastly, application challenges treating diseases. explore potential benefits while also addressing obstacles need be overcome. Furthermore, prospects field. In summary, underscores promise disease treatment highlights further research optimize utilization.
Язык: Английский
Процитировано
0
Journal of Controlled Release, Год журнала: 2024, Номер 377, С. 324 - 338
Опубликована: Ноя. 23, 2024
Язык: Английский
Процитировано
0