Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 377, P. 324 - 338
Published: Nov. 23, 2024
Language: Английский
Regenerative Biomaterials, Journal Year: 2024, Volume and Issue: 12
Published: Nov. 20, 2024
Abstract Low tumor enrichment remains a serious and urgent problem for drug delivery in cancer therapy. Accurate targeting of sites is still critical aim Though there have been variety strategies to improve the enrichment, biological barriers cause most delivered guests fail or be excreted before they work. Recently, cell membrane-based systems attracted huge amount attention due their advantages such as easy access, good biocompatibility immune escape, which contribute biomimetic structures specific surface proteins. Furthermore, are referred homologous-targeting function exhibit significantly high adhesion internalization homologous-type cells even though exact mechanism not entirely revealed. Here, we summarize sources characterizations membrane systems, including reconstructed single hybrid nano-/microcarriers, well engineered cells. Additionally, advanced applications these therapy categorized summarized according components membranes. The potential factors related homologous also discussed. By discussing applications, challenges opportunities, expect far-reaching development preclinic clinics.
Language: Английский
Citations
3
Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 4297 - 4308
Published: July 1, 2024
Purpose: To evaluate the prognostic significance of platelet distribution width-to-lymphocyte ratio (PDWLR) in patients with locoregionally advanced nasopharyngeal carcinoma (LA-NPC). Moreover, a nomogram based on PDWLR was built and validated to predict overall survival (OS) this population. Patients Methods: All LA-NPC who were diagnosed treated between January 2015 December 2017 at Guangxi Medical University Cancer Hospital included. Cox regression analyses performed assess clinical features that might affect OS screen for independent predictors. The predictors important variables used build validate predicting OS. Then, capability model estimated by discrimination, calibration usefulness. Risk stratification conducted using nomogram-calculated risk score, comparison high-risk group low-risk through Kaplan–Meier method. Results: This study included 746 patients. Multivariate analysis suggested age (hazard [HR]: 1.81, 95% confidence interval [CI]: 1.18– 2.78, P = 0.007), gender (HR: 2.03, CI: 1.12– 3.68, 0.019), pre-treatment plasma Epstein–Barr virus (EBV) DNA 1.55, 1.01– 2.39, 0.047), 2.61, 1.67– 4.09, < 0.001) Compared 8th edition TNM staging system, above four factors (T stage N stage) demonstrated better predictive performance. had ability identify individuals high risk. Conclusion: promising negative predictor LA-NPC. performance than current system. Keywords: nomogram, ratio, inflammatory biomarker, carcinoma,
Language: Английский
Citations
1
Aggregate, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 15, 2024
ABSTRACT While nanomedicine research shows a great progress in the treatment of cancer, it still faces challenges tumor recurrence and metastasis. Numerous studies have demonstrated intricate crosstalk between platelets cells. The re‐education by cells enables these to provide critical assistance for proliferation, recurrence, Engineered shown promising potential tumors, postoperative Different engineering technologies such as surface modification, gene editing, membrane coating, loading into hydrogels can produce multifunctional customized engineered platelets. These inherit key properties platelets, including long blood circulation, targeting, thrombus be stimulated generate derivatized particles. In this review, we elucidate role complex processes tumorigenesis progression summarize emerging paradigm therapy. purpose review is comprehensively explore value toward clinical providing valuable reference further development their broader applications field cancer
Language: Английский
Citations
0
Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(28), P. 11205 - 11215
Published: July 5, 2024
Lipid nanoparticles (LNPs) are emerging as one of the most promising drug delivery systems. The long-circulating effect intact LNPs (i-LNPs) is key to efficacy and toxicity in vivo. However, significant challenge specific sensitive detection i-LNPs. Herein, a dual-recognition fluorescence enzyme-linked immunosorbent assay (DR-FELISA) was developed directly isolate detect i-LNPs by combining separation with one-step signal amplification strategy. microplates captured enriched through antibody–antigen reaction. Dual-chol probes were spontaneously introduced into lipid bilayer i-LNPs, converting double-cholesterol probes. Finally, end dual-chol initiated localized scaffolding autocatalytic DNA circuits (SADC) system for further amplification. SADC provides efficient amplifier network structures self-assembled triggers. Simultaneous recognition surface PEG-lipid significantly eliminates interference from biological samples. detected high selectivity, ranging 0.2 1.25 mg/mL limit 0.1 mg/mL. Moreover, this method allows isolation quantitative analysis different formulations serum samples satisfactory recovery rate 94.8 116.3%. Thus, DR-FELISA an advanced platform exclusive providing new insights study quality intracorporal process complex formulations.
Language: Английский
Citations
0
ACS Nano, Journal Year: 2024, Volume and Issue: 18(43), P. 29421 - 29438
Published: Oct. 15, 2024
Over the past decade, a marked escalation in prevalence of hepatic pathologies has been observed, adversely impacting quality life for many. The predominant therapeutic strategy liver diseases pharmacological intervention; however, its efficacy is often constrained. Currently, liposomes are tiny structures that can deliver drugs directly to targeted areas, enhancing their effectiveness. Specifically, cell membrane-associated have gained significant attention. Despite this, there still much learn about binding mechanism this type liposome. Thus, review comprehensively summarizes relevant information on liposomes, including clinical applications and future development directions. First, we will briefly introduce composition types liposomes. We provide an overview structure discuss various associated with membranes. Second, thoroughly strategies drug delivery using these Lastly, application challenges treating diseases. explore potential benefits while also addressing obstacles need be overcome. Furthermore, prospects field. In summary, underscores promise disease treatment highlights further research optimize utilization.
Language: Английский
Citations
0
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 377, P. 324 - 338
Published: Nov. 23, 2024
Language: Английский
Citations
0