International Journal of Applied Pharmaceutics,
Год журнала:
2025,
Номер
unknown, С. 119 - 126
Опубликована: Май 7, 2025
Microneedles
(MNDs)
have
emerged
as
a
transformative
technology
in
transdermal
drug
delivery,
offering
minimally
invasive
alternative
to
traditional
hypodermic
needles.
These
microscale
devices
allow
the
direct
delivery
of
medication
into
dermal
layers
by
creating
tiny
punctures
skin.
This
article
looks
in-depth
at
various
types
MNDs,
including
hollow,
hydrogel-forming,
coated,
dissolvable,
and
solid
along
with
associated
manufacturing
techniques.
are
used
many
medical
disciplines
reduce
side
effects,
increase
patient
compliance,
enhance
efficacy.
Examples
these
specialties
include
pain
treatment,
hormone
administration,
vaccine
cosmetic
surgeries.
Despite
their
promising
advantages,
problems
education,
regulatory
obstacles,
scalability
need
be
fixed.
describes
current
status
MNDs
technology,
discusses
potential
changes
suggests
future
directions
for
study
development.
Pharmaceutics,
Год журнала:
2024,
Номер
16(11), С. 1398 - 1398
Опубликована: Окт. 30, 2024
Microneedle
technology
revolutionizes
ocular
drug
delivery
by
addressing
challenges
in
treating
diseases.
This
review
explores
its
potential
impact,
recent
advancements,
and
clinical
uses.
minimally
invasive
technique
offers
precise
control
of
to
the
eye,
with
various
microneedle
types
showing
penetrate
barriers
cornea
sclera,
ensuring
effective
delivery.
Recent
advancements
have
improved
safety
efficacy,
offering
sustained
controlled
for
conditions
like
age-related
macular
degeneration
glaucoma.
While
promising,
such
as
regulatory
long-term
biocompatibility
persist.
Overcoming
these
through
interdisciplinary
research
is
crucial.
Ultimately,
presents
a
revolutionary
method
significantly
enhance
disease
treatment,
marking
new
era
eye
care.
International Journal of Pharmaceutics X,
Год журнала:
2024,
Номер
8, С. 100310 - 100310
Опубликована: Дек. 1, 2024
Curcumin
(CUR)
is
highly
promising
for
topical
therapeutic
applications,
but
water-insolubility
one
of
the
major
challenges
plaguing
its
drugability,
while
conventional
lipid
nanocarriers
are
limited
by
low
drug-carrying
capacity,
many
additives,
and
complex
processes.
In
current
work,
we
constructed
a
composite
carrier
integrated
with
cyclodextrin
metal-organic
framework
(γ-CD-MOF)
nanosponge
(β-CDNS),
in
which
γ-CD-MOF
had
13.9
%
drug
loading
267.1-fold
increase
solubility
water
CUR,
β-CDNS
showed
bioadhesion
further
increasing
solubility.
The
(γ-CD-MOF@β-CDNS)
significantly
improved
vitro
release
transdermal
permeation
absorption
properties
excellent
create
an
advantage
local
administration
treating
diseases
high
exudate,
prevents
affected
area
from
deteriorating
condition
counter-absorption
formulation.
Thus,
this
contributes
new
option
to
address
delivery
insoluble
drugs
offers
strategy
clinical
application
CUR.
Pharmaceutics,
Год журнала:
2025,
Номер
17(1), С. 128 - 128
Опубликована: Янв. 17, 2025
Alzheimer's
disease
(AD)
represents
an
escalating
global
health
crisis,
constituting
the
leading
cause
of
dementia
among
elderly
and
profoundly
impairing
their
quality
life.
Current
FDA-approved
drugs,
such
as
rivastigmine,
donepezil,
galantamine,
memantine,
offer
only
modest
symptomatic
relief
are
frequently
associated
with
significant
adverse
effects.
Faced
this
challenge
in
line
advances
understanding
pathophysiology
neurodegenerative
condition,
various
innovative
therapeutic
strategies
have
been
explored.
Here,
we
review
novel
approaches
inspired
by
advanced
knowledge
underlying
pathophysiological
mechanisms
disease.
Among
alternatives,
immunotherapy
stands
out,
employing
monoclonal
antibodies
to
specifically
target
eliminate
toxic
proteins
implicated
AD.
Additionally,
use
medicinal
plants
is
examined,
synergistic
effects
components
may
confer
neuroprotective
properties.
The
modulation
gut
microbiota
also
addressed
a
peripheral
strategy
that
could
influence
neuroinflammatory
degenerative
processes
brain.
Furthermore,
potential
emerging
approaches,
microRNAs
regulate
key
cellular
nanotherapy,
which
enables
precise
drug
delivery
central
nervous
system,
analyzed.
Despite
promising
these
strategies,
incidence
continues
rise.
Therefore,
it
proposed
achieving
effective
treatment
future
require
integration
combined
maximizing
different
interventions.
Pharmaceuticals,
Год журнала:
2025,
Номер
18(2), С. 195 - 195
Опубликована: Янв. 31, 2025
Drugs
administered
by
means
of
extravascular
routes
drug
administration
must
be
absorbed
into
the
systemic
circulation,
which
involves
movement
molecules
across
biological
barriers
such
as
epithelial
cells
that
cover
mucosal
surfaces
or
stratum
corneum
covers
skin.
Some
drugs
exhibit
poor
permeation
membranes
may
experience
excessive
degradation
during
first-pass
metabolism,
tends
to
limit
their
bioavailability.
Various
strategies
have
been
used
improve
Absorption
enhancement
include
co-administration
chemical
enhancers,
enzymes,
and/or
efflux
transporter
inhibitors,
changes,
and
specialized
dosage
form
designs.
Models
with
physiological
relevance
are
needed
evaluate
efficacy
absorption
techniques.
in
vitro
cell
culture
models
ex
vivo
tissue
explored
quantify
effectiveness
strategies.
This
review
deliberates
on
use
for
evaluation
selected
including
nasal,
oromucosal,
pulmonary,
oral,
rectal,
transdermal
administration.
This
review
explores
the
synergistic
potential
of
MOF-based
MNs
and
details
strategies
for
integrating
MOFs
various
guest
molecules
within
into
to
enhance
transdermal
therapeutic
applications.
