KAISO Promotes Poor Prognosis in Hepatocellular Carcinoma Patients by Enhancing Neutrophil Infiltration via IGFBP1 DOI

Zhou Jiang,

Yiqiang Pang,

Haojun Wang

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Сен. 18, 2024

Abstract Background KAISO is a transcriptional regulator involved in gene expression, cell proliferation, and apoptosis, linked to cancer prognosis tumor aggressiveness, making it potential bi-omarker therapeutic target. Methods: We used bioinformatics analyses evaluate expression its effect on survival across 33 types of pan-cancer. also examined the link between immune infiltration. To investigate control down-stream proteins by KAISO, we dual-luciferase reporter assays, electrophoretic mobility shift assays (EMSA), chromatin immunoprecipitation (ChIP). Additionally, validated role regulating infiltration using subcutaneous model animals human samples. Results: Our research revealed that crucial growth progression various malignancies, including hepatocellular carcinoma (HCC). demonstrated high associated with poor HCC. was found regulate transcription IGFBP1 neutrophil influence HCC pro-liferation through cycle-related molecular pathways. Finally, confirmed reducing can inhibit growth. Conclusion: findings suggest could be an important biomarker target for patients.

Язык: Английский

Napabucasin deactivates STAT3 and promotes mitoxantrone-mediated cGAS-STING activation for hepatocellular carcinoma chemo-immunotherapy DOI
Lingzhi Wang, Shengnan Bi, Zhuo Li

и другие.

Biomaterials, Год журнала: 2024, Номер 313, С. 122766 - 122766

Опубликована: Авг. 22, 2024

Язык: Английский

Процитировано

8
Nano co-delivery of doxorubicin and plumbagin achieves synergistic chemotherapy of hepatocellular carcinoma DOI
Chenyu Cao, Yifei Li,

Fangzhou Shi

и другие.

International Journal of Pharmaceutics, Год журнала: 2024, Номер 661, С. 124424 - 124424

Опубликована: Июль 4, 2024

Язык: Английский

Процитировано

6
A nanodrug provokes antitumor immune responses via synchronous multicellular regulation for enhanced cancer immunotherapy DOI

Keze Hong,

Jianrong Cao,

Weiting Jiang

и другие.

Journal of Colloid and Interface Science, Год журнала: 2024, Номер 678, С. 750 - 762

Опубликована: Сен. 4, 2024

Язык: Английский

Процитировано

5
Mapping the evolution and research landscape of ferroptosis-targeted nanomedicine: insights from a scientometric analysis DOI Creative Commons
Siyang Cao, Yihao Wei, Yaohang Yue

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Сен. 25, 2024

Notable progress has been made in "ferroptosis-based nano drug delivery systems (NDDSs)" over the past 11 years. Despite ongoing absence of a comprehensive scientometric overview and up-to-date scientific mapping research, especially regarding evolution, critical research pathways, current landscape, central investigative themes, future directions.

Язык: Английский

Процитировано

4
Formulation and optimization of glycyrrhetinic acid-modified pH-sensitive curcumin liposomes for anti-hepatocellular carcinoma DOI
Jie Wang,

Xuemei Gu,

Xia Gao

и другие.

Pharmaceutical Development and Technology, Год журнала: 2025, Номер unknown, С. 1 - 24

Опубликована: Фев. 11, 2025

In order to enhance the therapeutic value of curcumin in liver cancer treatment, glycyrrhetinic acid-modified pH-sensitive liposomes (GA-pH-Lip@Cur) was developed.GA-pH-Lip@Cur prepared using a thin film dispersion ultrasonication method, and optimal formulation process selected through single-factor experiments Box-Behnken design-response surface methodology. The were evaluated for their morphological appearance, particle size, vitro release at different pH levels, biocompatibility. anti-tumor effect GA-pH-Lip@Cur assessed cell viability assays (CCK-8). vivo hepatic targeting anti-liver tumor efficacy pharmacokinetic pharmacological experiments.The results indicated that optimized exhibited uniform size distribution, good stability, with sustained behavior. Compared conventional liposomes, showed prolonged average retention time significantly increased distribution tissues, indicating excellent targeting. Both evaluations demonstrated effectiveness inhibiting proliferation suppressing growth tumor-bearing mice. conclusion, GA-pH-Lip@Cur, by leveraging acidic microenvironment overexpression acid receptors cells, encapsulates improve its bioavailability, target delivery sites.

Язык: Английский

Процитировано

0
Progress in the Application of Novel Nanomaterials in Targeted Therapy for Liver Cancer DOI Creative Commons
Xin Wei,

Weihua Cao,

Shiyu Wang

и другие.

International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 2623 - 2643

Опубликована: Март 1, 2025

In recent years, nanobiotechnology, widely used in hepatoma, holds great promise for improving targeted hepatocarcinoma therapy. On account of the unique properties low toxicity, good tolerance, biocompatibility, and biodegradability new nanomaterials, a drug delivery system (TDDS) has been constructed, which can boost therapeutic effect hepatoma-targeted drugs, reduce minimize off target reactions by enhancing permeability retention (EPR) active targeting, thus existing liver cancer therapy strategies. Different nanoparticles have their own advantages disadvantages. They be loaded with multiple drugs on same nanoparticle also surface modified each other to achieve synergistic anti-tumor effects. This essay provides comprehensive overview current status hepatocarcinoma, nanoparticles' structure, disadvantages nanoparticle, application progress cancer. We hope provide basis future clinical hepatoma using nanotechnology.

Язык: Английский

Процитировано

0
Nanomaterials in the diagnosis and treatment of gastrointestinal tumors: New clinical choices and treatment strategies DOI Creative Commons
Liping Chen,

Qingqing Li

Materials Today Bio, Год журнала: 2025, Номер unknown, С. 101782 - 101782

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
cGAS-STING activation by nanodelivery of teniposide achieves colorectal cancer chemo-immunotherapy DOI

Anqi Liao,

Junjun Chen,

Fangzhou Shi

и другие.

European Polymer Journal, Год журнала: 2024, Номер 219, С. 113379 - 113379

Опубликована: Авг. 9, 2024

Язык: Английский

Процитировано

3
CAF-derived miR-642a-3p supports migration, invasion, and EMT of hepatocellular carcinoma cells by targeting SERPINE1 DOI Creative Commons
Shuo Zhang, Gang Cao,

Shuijie Shen

и другие.

PeerJ, Год журнала: 2024, Номер 12, С. e18428 - e18428

Опубликована: Ноя. 11, 2024

Background Cancer-associated fibroblasts (CAFs) and hepatocellular carcinoma (HCC) cells interact to promote HCC progression, but the underlying mechanisms remain unclear. Serpin family E member 1 (SERPINE1) has conflicting roles in HCC, microRNAs (miRNAs) are known regulate tumor progression through intercellular communication. Therefore, we investigated potential involvement of miRNA/SERPINE1 axis crosstalk between CAFs cells. Methods In this study, candidate miRNAs targeting SERPINE1 3′ UTR were predicted using multiple miRNA databases. The mRNA expression Huh7 was assessed after co-culture with RT-qPCR. cell proliferation invasion detected siRNA. functions CAF-derived miR-642a-3p/SERPINE1 examined CCK-8, wound healing, transwell assays, western blot, dual-luciferase reporter assays. Moreover, a orthotopic xenograft model used investigate contribution miR-642a-3p knockdown HCC. Results decreased, while increased co-cultured CAFs. enhanced as well expression. overexpression promoted migration, invasion, epithelial-mesenchymal transition (EMT) by SERPINE1, yielded opposite effect. Rescue experiments confirmed that attenuated inhibitory effects on EMT Importantly, suppressed growth liver tumors. Conclusion facilitated cells, suggesting can be therapeutic target for

Язык: Английский

Процитировано

3
Biotinylated polyaminoacid-based nanoparticles for the targeted delivery of lenvatinib towards hepatocarcinoma DOI
Paola Varvarà, Salvatore Emanuele Drago, E. Esposito

и другие.

International Journal of Pharmaceutics, Год журнала: 2024, Номер 662, С. 124537 - 124537

Опубликована: Июль 28, 2024

Язык: Английский

Процитировано

1