Engineering Dual Active Sites and Defect Structure in Nanozymes to Reprogram Jawbone Microenvironment for Osteoradionecrosis Therapy DOI Creative Commons

Zheng Cheng,

Yuchen Wang,

Haobo Lin

и другие.

Advanced Science, Год журнала: 2024, Номер unknown

Опубликована: Дек. 17, 2024

Four to eight percent of patients with head and neck cancer will develop osteoradionecrosis the jaw (ORNJ) after radiotherapy. Various radiation-induced tissue injuries are associated reactive oxygen nitrogen species (RONS) overproduction. Herein, Fe doping is used in VO

Язык: Английский

Defect engineering synergistically boosts the catalytic activity of Fe-MoOv for highly efficient breast mesh antitumor therapy DOI
Wenjing Yang,

Chuanyin Zhou,

Chongxian He

и другие.

Journal of Colloid and Interface Science, Год журнала: 2024, Номер 678, С. 260 - 271

Опубликована: Авг. 25, 2024

Язык: Английский

Процитировано

29
Rational Design of Nanozymes for Engineered Cascade Catalytic Cancer Therapy DOI

Xiuna Jia,

Erkang Wang, Jin Wang

и другие.

Chemical Reviews, Год журнала: 2025, Номер unknown

Опубликована: Янв. 27, 2025

Nanozymes have shown significant potential in cancer catalytic therapy by strategically catalyzing tumor-associated substances and metabolites into toxic reactive oxygen species (ROS) situ, thereby inducing oxidative stress promoting cell death. However, within the complex tumor microenvironment (TME), rational design of nanozymes factors like activity, reaction substrates, TME itself significantly influence efficiency ROS generation. To address these limitations, recent research has focused on exploring that affect activity developing nanozyme-based cascade systems, which can trigger two or more processes tumors, producing therapeutic achieving efficient stable with minimal side effects. This area remarkable progress. Perspective provides a comprehensive overview nanozymes, covering their classification fundamentals. The regulation nanozyme strategies are discussed detail. Furthermore, representative paradigms for successful construction systems treatment summarized focus revealing underlying mechanisms. Finally, we current challenges future prospects development biomedical applications.

Язык: Английский

Процитировано

4
Recent advances in nano-molybdenum oxide for photothermal cancer therapy DOI

S Chen,

Ping Zhang,

Hongmei Bai

и другие.

Nanomedicine, Год журнала: 2025, Номер unknown, С. 1 - 19

Опубликована: Март 10, 2025

Cancer remains a significant global health challenge, driving the search for innovative treatments. Photothermal therapy (PTT) has emerged as promising approach, using photothermal agents to convert near-infrared (NIR) light into heat tumor ablation. Among these agents, nano-molybdenum oxide, particularly non-stoichiometric MoO3-x (0 < x 1), stands out due its unique defect structure, strong NIR absorption, high conversion efficiency (PCE), and pH-responsive degradation. This review summarized recent advancements in oxide PTT, covering classification, synthesis, surface modification, tumor-targeting mechanisms. Subsequently, we explored applications PTT combination therapies, evaluated biocompatibility toxicity, discussed current achievements, challenges, future perspectives cancer treatment.

Язык: Английский

Процитировано

0
Amino Acid and Au(III) Self-Assembled Supramolecular Nanozymes for Antimicrobial Applications DOI

Yunzhu Xu,

Dahai Hou, Min Zhao

и другие.

ACS Applied Nano Materials, Год журнала: 2024, Номер unknown

Опубликована: Сен. 21, 2024

Язык: Английский

Процитировано

1
Nanozymes as Antibacterial Agents: New Concerns in Design and Enhancement Strategies DOI
Xianhang Yan, Xiaoqiang Li,

Pei‐Kai Yu

и другие.

ChemBioChem, Год журнала: 2024, Номер 26(1)

Опубликована: Окт. 21, 2024

Abstract Nanozymes exhibiting natural enzyme‐mimicking catalytic activities as antibacterial agents present several advantages, including high stability, low cost, broad‐spectrum activity, ease of preparation and storage, minimal bacterial resistance. Consequently, they have attracted significant attention in recent years. However, the rapid expansion antimicrobial nanozyme research has resulted pioneering reviews that do not comprehensively address emerging concerns enhancement strategies within this field. This paper first summarizes factors influencing intrinsic activity nanozymes; subsequently, we outline new considerations for designing nanozymes with enhanced functionality biosafety features such degradable, imageable, targeted, bacterial‐binding well those capable selectively targeting pathogenic bacteria while sparing normal cells probiotics. Furthermore, review novel involving external physical stimuli (light or ultrasound), introduction extrinsic small molecules, self‐supplying H 2 O to enhance under physiological conditions characterized by concentrations . Additionally, non‐redox operate independently highly toxic reactive oxygen species (ROS) alongside designed combat less common bacteria. Finally, discuss current issues, challenges faced field, future prospects nanozymes.

Язык: Английский

Процитировано

1
Engineering Dual Active Sites and Defect Structure in Nanozymes to Reprogram Jawbone Microenvironment for Osteoradionecrosis Therapy DOI Creative Commons

Zheng Cheng,

Yuchen Wang,

Haobo Lin

и другие.

Advanced Science, Год журнала: 2024, Номер unknown

Опубликована: Дек. 17, 2024

Four to eight percent of patients with head and neck cancer will develop osteoradionecrosis the jaw (ORNJ) after radiotherapy. Various radiation-induced tissue injuries are associated reactive oxygen nitrogen species (RONS) overproduction. Herein, Fe doping is used in VO

Язык: Английский

Процитировано

1