Chinese Chemical Letters, Год журнала: 2024, Номер unknown, С. 110802 - 110802
Опубликована: Дек. 1, 2024
Язык: Английский
Journal of Controlled Release, Год журнала: 2025, Номер 379, С. 59 - 76
Опубликована: Янв. 8, 2025
Язык: Английский
Процитировано
6
Small Methods, Год журнала: 2024, Номер unknown
Опубликована: Июль 23, 2024
Abstract Hyaluronic acid (HA) is a naturally occurring polysaccharide found in the extracellular matrix with broad applications disease treatment. HA possesses good biocompatibility, biodegradability, and ability to interact various cell surface receptors. Its wide range of molecular weights modifiable chemical groups make it an effective drug carrier for delivery. Additionally, overexpression specific receptors on surfaces many states enhances accumulation drugs at pathological sites through receptor binding. In this review, modification drugs, major proteins, latest advances receptor‐targeted nano delivery systems (DDS) treatment tumors inflammatory diseases are summarized. Furthermore, functions varying vivo selection methods different discussed.
Язык: Английский
Процитировано
15
Materials Today Bio, Год журнала: 2025, Номер 31, С. 101534 - 101534
Опубликована: Янв. 29, 2025
The treatment and management of kidney diseases pose a significant global burden. Due to the presence blood circulation barriers glomerular filtration barriers, drug therapy for faces challenges such as poor renal targeting, short half-life, severe systemic side effects, severely hindering therapeutic progress. Therefore, research development kidney-targeted agents is great clinical significance. In recent years, application nanotechnology in field nephrology has shown potential revolutionizing diagnosis diseases. Carefully designed nanomaterials can exhibit optimal biological characteristics, influencing various aspects circulation, retention, excretion. Rationally designing modifying based on anatomical structure pathophysiological environment achieve highly specific or nanodrug delivery systems both feasible promising. Based targeted diseases, this review discusses advantages limitations current nanomedicine summarizes active/passive targeting strategies, order further promote through preliminary summary previous studies future prospects.
Язык: Английский
Процитировано
2
Journal of Controlled Release, Год журнала: 2025, Номер 380, С. 404 - 416
Опубликована: Фев. 10, 2025
Язык: Английский
Процитировано
2
Journal of Controlled Release, Год журнала: 2025, Номер 380, С. 927 - 942
Опубликована: Фев. 21, 2025
Язык: Английский
Процитировано
1
Journal of Colloid and Interface Science, Год журнала: 2024, Номер 680, С. 261 - 273
Опубликована: Ноя. 3, 2024
Язык: Английский
Процитировано
5
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 179, С. 117409 - 117409
Опубликована: Сен. 8, 2024
Язык: Английский
Процитировано
3
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Ноя. 5, 2024
Non-invasive imaging in the near-infrared region (NIR) offers enhanced tissue penetration, reduced spontaneous fluorescence of biological tissues, and improved signal-to-noise ratio (SNR), rendering it more suitable for vivo deep imaging. In recent years, a plethora NIR photoresponsive materials have been employed disease diagnosis, particularly acute kidney injury (AKI). These encompass inorganic nonmetallic such as carbon (C), silicon (Si), phosphorus (P), upconversion nanoparticles (UCNPs); precious metal like gold silver; well small molecule organic semiconductor polymer with near infrared responsiveness. enable effective therapy triggered by light serve valuable tools monitoring AKI living systems. The review provides concise overview current state pathological characteristics AKI, followed an exploration application nanomaterials AKI. Finally, presents design challenges prospects associated
Язык: Английский
Процитировано
3
Advanced Healthcare Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 19, 2025
Abstract Liver ischemia and reperfusion (I/R) injury is a reactive oxygen species (ROS)‐related disease that occurs during liver transplantation resection hinders postoperative function recovery. Current approaches to alleviate I/R have limited effectiveness due the short circulation time, poor solubility, severe side effects of conventional antioxidants anti‐inflammatory drugs. Herein, universal strategy proposed fabricate Trojan horse‐like biohybrid nanozyme (THBN) with hepatic‐targeting capabilities. Tannic acid (TA) mediates adeno‐associated virus (AAV8) decoration onto 2D Ti 3 C 2 nanosheets, resulting in THBN size 116.2 ± 9.5 nm. Remarkably, exhibits catalase (CAT)‐like activity, broad‐spectrum ROS scavenging activity targeted delivery tissue owing presence AAV8. Both vivo vitro experiments confirmed efficacy attenuating by mitigating inflammation oxidative stress inhibiting hepatocellular apoptosis. RNA‐seq analysis suggests may activating PKC pathway. The effective targeting therapeutic capabilities represent an advancement nanotherapeutics for hepatic ischemia‒reperfusion injury, shedding light on promising potential this next‐generation nanotherapeutic approach.
Язык: Английский
Процитировано
0
ACS Omega, Год журнала: 2025, Номер 10(4), С. 3610 - 3621
Опубликована: Янв. 22, 2025
Aging is an inevitable multifactor process that causes a decline in organ function and increases the risk of age-related diseases death. Thus, development highly effective safe therapeutic strategies to delay aging urgently required. In this study, we isolated natural melanin nanozymes (NMNs) from ink sacs live octopuses. The NMNs exhibited excellent superoxide-dismutase-mimicking radical scavenging activities. SAMP8 mice, treatment with improved their cognition memory functions while restoring aging-impaired liver lipid metabolism, thereby prolonging lifespan. Moreover, reversed metabolic changes aged brains reconstructed gut microbiota composition by enhancing microbial community diversity. Our findings indicate could be promising approach for delaying preventing age-associated physiological humans.
Язык: Английский
Процитировано
0