Hyaluronic Acid Receptor‐Mediated Nanomedicines and Targeted Therapy

Small Methods, Год журнала: 2024, Номер unknown

Опубликована: Июль 23, 2024

Abstract Hyaluronic acid (HA) is a naturally occurring polysaccharide found in the extracellular matrix with broad applications disease treatment. HA possesses good biocompatibility, biodegradability, and ability to interact various cell surface receptors. Its wide range of molecular weights modifiable chemical groups make it an effective drug carrier for delivery. Additionally, overexpression specific receptors on surfaces many states enhances accumulation drugs at pathological sites through receptor binding. In this review, modification drugs, major proteins, latest advances receptor‐targeted nano delivery systems (DDS) treatment tumors inflammatory diseases are summarized. Furthermore, functions varying vivo selection methods different discussed.

Язык: Английский

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A promising mesoporous silica carrier material for the diagnosis and treatment of liver diseases: recent research advances

Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

The therapeutic diagnosis of liver diseases has garnered significant interest within the medical community.

Язык: Английский

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Hepatic stellate cell-targeted chemo-gene therapy for liver fibrosis using fluorinated peptide-lipid hybrid nanoparticles

Journal of Controlled Release, Год журнала: 2024, Номер 376, С. 601 - 617

Опубликована: Окт. 25, 2024

Язык: Английский

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Targeted delivery of polymeric NO-donor micelles to hepatic stellate cells for restoration of liver function and inhibition of hepatic fibrosis

Journal of Controlled Release, Год журнала: 2025, Номер 379, С. 466 - 477

Опубликована: Янв. 17, 2025

Язык: Английский

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Advances in intrahepatic and extrahepatic vascular dysregulations in cirrhotic portal hypertension

Frontiers in Medicine, Год журнала: 2025, Номер 12

Опубликована: Янв. 31, 2025

Cirrhotic portal hypertension, the most prevalent and clinically significant complication of liver cirrhosis, manifests as elevated venous pressure is associated with severe complications. Although much research on mechanisms hypertension has focused fibrosis, less attention been given to role intrahepatic extrahepatic vascular dysfunction, particularly respect vasculature. While hepatic fibrosis in cirrhotic undeniable, underlying involving vasculature are highly complex. Sinusoidal capillarization endothelial dysfunction contribute increased resistance. Hemodynamic changes circulation, including splanchnic vasodilation hyperdynamic play a development hypertension. Additionally, therapeutic strategies targeting these diverse, improvement sinusoidal microcirculation, therapies stellate cells activation, pharmacological modulation systemic tone. Therefore, this review, we will discuss vascular-related treatment progress cirrhosis provide new theoretical basis practical guidance for clinical treatment.

Язык: Английский

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Zwitterionic lipid nanoparticles for efficient siRNA delivery and hypercholesterolemia therapy with rational charge self-transformation

Theranostics, Год журнала: 2025, Номер 15(8), С. 3693 - 3712

Опубликована: Март 1, 2025

Rationale: Effective delivery of small interfering RNA (siRNA) remains a significant challenge in treating hypercholesterolemia due to biocompatibility, cellular uptake, and endosomal escape issues. Rational regulation carrier surface charge contributes efficient siRNA vivo. Methods: This study introduces zwitterionic lipid nanoparticles (ZwiLNPs) as novel solution these challenges. By leveraging the unique properties polymers, we achieved robust encapsulation targeted delivery. The design ZwiLNPs facilitates self-transformation response physiological conditions, which enhances their biocompatibility uptake efficiency. Result: In vivo studies demonstrated liver-targeting capabilities ZwiLNPs, with improved following internalization. Comparative analyses confirmed that outperform conventional terms both release. Conclusion: These findings position promising platform for interference therapies, particularly other lipid-related disorders.

Язык: Английский

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Engineered Intelligent Microenvironment Responsive Prodrug Conjugates Navigated by Bioinspired Lipoproteins for Reversing Liver Fibrosis

Small Methods, Год журнала: 2025, Номер unknown

Опубликована: Март 19, 2025

Abstract Liver fibrosis (LF) is characterized by excessive production of reactive oxygen species (ROS), abnormal activation hepatic stellate cells (HSCs), and subsequent extracellular matrix (ECM) deposition. The complexity multiple interrelated pathways involved in this process makes it challenging for monotherapy to achieve the desired therapeutic effects. To address issue, study designs a ROS‐activated heterodimer conjugate (VTO) collaboratively alleviate LF. Additionally, biomimetic high‐density lipoprotein utilized encapsulation, resulting formation PL‐VTO, which enables natural liver targeting. Once PL‐VTO delivered fibrotic liver, can respond release both parent drugs upon encountering high ROS microenvironment, effectively scavenge ROS, induce quiescence activated HSCs, reduce collagen deposition, ultimately reversing Overall, presents feasible versatile nanotherapeutic approach enhance prodrug‐driven treatment

Язык: Английский

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Sulfur dioxide-releasing nanomotors improve the therapeutic effect of liver fibrosis by restoring the fenestrae of sinusoids

Journal of Colloid and Interface Science, Год журнала: 2025, Номер unknown, С. 137557 - 137557

Опубликована: Апрель 1, 2025

Язык: Английский

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Nanoparticle-based therapeutic strategies for chronic liver diseases: Advances and insights

Liver Research, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

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A c(RGDyK)-modified ROS-responsive polymeric micelle for hepatic stellate cell targeting

Chinese Chemical Letters, Год журнала: 2025, Номер unknown, С. 111237 - 111237

Опубликована: Апрель 1, 2025

Язык: Английский

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