Abstract
The
aim
of
this
study
was
to
develop
a
new
nicotine
transdermal
patch:
S‐(‐)‐Nicotine‐loaded
nano
flexible
liposome
hydrogel
patch
(S‐(‐)‐Nicotine‐NFL‐HGP),
which
combined
and
achieve
the
long‐lasting
sustained
release
S‐(‐)‐Nicotine
for
treatment
withdrawal
syndrome
(NWS).
nanoscale
liposomes
(S‐(‐)‐Nicotine‐NFL)
were
prepared
using
thin
film
hydration
method,
then
with
three‐dimensional
structured
prepare
S‐(‐)‐Nicotine‐NFL‐HGP.
initial
bond
strength
(IBS)
(18
±
2)
s,
lasting
(EBS)
(23.5
3.4)
appearance
pale
yellow.
cumulative
rate
64.8%
within
48
h
Higuchi
equation
drug
process
y
=
9.47x
1/2
−1.13
(
R
2
0.99412).
transmittance
per
unit
area
after
(1047
25.0)
µg/cm
dermal
retention
(35.1
4.2)
.
showed
highest
fit
in
experiments
S‐(‐)‐Nicotine.
Stability
results
that
IBS,
EBS,
appearance,
performance
almost
unchanged
90
days,
had
excellent
stability.
has
potential
application
prospects.
Abstract
Hyaluronic
acid
(HA)
is
a
naturally
occurring
polysaccharide
found
in
the
extracellular
matrix
with
broad
applications
disease
treatment.
HA
possesses
good
biocompatibility,
biodegradability,
and
ability
to
interact
various
cell
surface
receptors.
Its
wide
range
of
molecular
weights
modifiable
chemical
groups
make
it
an
effective
drug
carrier
for
delivery.
Additionally,
overexpression
specific
receptors
on
surfaces
many
states
enhances
accumulation
drugs
at
pathological
sites
through
receptor
binding.
In
this
review,
modification
drugs,
major
proteins,
latest
advances
receptor‐targeted
nano
delivery
systems
(DDS)
treatment
tumors
inflammatory
diseases
are
summarized.
Furthermore,
functions
varying
vivo
selection
methods
different
discussed.
Gels,
Год журнала:
2024,
Номер
10(11), С. 703 - 703
Опубликована: Окт. 30, 2024
Hyaluronic
acid
(HA),
an
important
natural
polysaccharide
and
meanwhile,
essential
component
of
extracellular
matrix
(ECM),
has
been
widely
used
in
tissue
repair
regeneration
due
to
its
high
biocompatibility,
biodegradation,
bioactivity,
the
versatile
chemical
groups
for
modification.
Specially,
HA-based
dynamic
hydrogels,
compared
with
conventional
offer
adaptable
network
biomimetic
microenvironment
optimize
process
a
striking
resemblance
ECM.
Herein,
this
review
comprehensively
summarizes
recent
advances
hydrogels
focuses
on
their
applications
articular
cartilage
repair.
First,
fabrication
methods
advantages
HA
are
presented.
Then,
illustrated
from
perspective
cell-free
cell-encapsulated
and/or
bioactive
molecules
(drugs,
factors,
ions).
Finally,
current
challenges
prospective
directions
outlined.
Bioengineering,
Год журнала:
2025,
Номер
12(2), С. 205 - 205
Опубликована: Фев. 19, 2025
Myocardial
infarction
(MI)
is
a
cardiovascular
disease
(CVD)
with
high
morbidity
and
mortality
worldwide,
which
serious
threat
to
human
life
health.
Inflammatory
immune
responses
are
initiated
immediately
after
MI,
unbalanced
inflammation
post-MI
can
lead
cardiac
dysfunction,
scarring,
ventricular
remodeling,
emphasizing
the
critical
need
for
an
effective
inflammation-regulating
treatment.
With
development
of
novel
therapies,
drug
delivery
system
specific
inflammatory
cells
offers
significant
potential.
In
this
review,
we
introduce
fibroblasts
involved
in
MI
summarize
newly
developed
systems
related
use
injectable
hydrogels,
patches,
nanoparticles,
extracellular
vesicles
(EVs).
Finally,
highlight
recent
trends
cell-targeting
involving
different
strategies
that
facilitate
treatment
MI.
Current Cardiology Reports,
Год журнала:
2025,
Номер
27(1)
Опубликована: Март 20, 2025
Abstract
Purpose
of
Review
The
rising
global
prevalence
cardiovascular
disease
is
driving
the
need
for
innovative
biotherapeutics.
Recently,
exosomes-extracellular
vesicles
involved
in
paracrine
signaling
have
shown
promise
aiding
heart
repair
associated
with
conditions.
Their
therapeutic
potential
encompasses
several
beneficial
mechanisms,
including
anti-fibrosis,
anti-inflammation,
pro-angiogenesis,
anti-oxidation,
and
anti-apoptosis,
all
contributing
to
improved
cardiac
function.
This
review
provides
a
comprehensive
overview
exosomes
highlights
latest
research
on
their
effectiveness
addressing
current
challenges
regenerative
medicine.
Recent
Findings
Current
approaches
revolve
around
elucidating
enhancing
how
different
cell
types,
cargo,
delivery
methods
impact
healing
pathological
environment.
Summary
emerging
field
exosome
promising
regeneration
due
effects
exosomal
cargo.
expansion
mechanistic
knowledge
optimization
techniques
are
required
before
standard
clinical
application.
Chem & Bio Engineering,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 18, 2025
Injectable
hydrogels
(IHs)
have
garnered
significant
attention
in
biomedical
applications
due
to
their
minimally
invasive
nature,
adaptability,
and
high
degree
of
customization.
However,
traditional
design
methods
IHs
limitations
addressing
complex
clinical
needs,
such
as
precise
regulation
the
gelation
time
mechanical
strength
within
a
wide
window.
Hyperbranched
polymers
(HBPs),
unique
highly
branched
structures
abundant
functional
sites,
can
be
easily
prepared
functionalized
enable
decoupled
modulation
properties
address
challenges
IHs.
Our
research
group
developed
library
HBPs
via
dynamically
controllable
polymerization
method
built
series
adjustable,
controllable,
responsive
based
on
resulting
HBPs.
The
fed
by
demonstrate
an
adjustable
process,
wide-range
tuning
properties,
responsiveness
demand,
which
show
capabilities
various
applications.
In
this
review,
we
summarize
role
self-healing
ability,
achieving
through
extending
them
broad
range
are
still
its
infancy.
This
review
provides
overview
fabricated
variety
multifunctional
HBPs,
diverse
fields
also
presented.
Meanwhile,
point
out
future
development
potential
challenges.
Macromolecular Rapid Communications,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 13, 2025
Abstract
Liposome‐based
formulations,
while
facilitating
drug
penetration
across
physiological
barriers,
face
considerable
challenges,
including
instability,
rapid
clearance
in
vivo,
and
inadequate
control
over
release.
Incorporating
liposomes
into
hydrogels
presents
a
promising
approach
to
enhancing
stability
sustaining
delivery.
However,
optimizing
their
administration,
responsiveness,
synergistic
interaction
with
the
tissue
process
improve
permeation
efficiency
bioavailability
remains
critical
challenge.
To
address
these
limitations,
this
study
introduces
an
intelligent,
injectable
hydrogel
delivery
system
based
on
crosslinking
of
thiolated
hyaluronic
acid
versatile
hyperbranched
PEG
macromer
(HPM).
The
high
reactivity
acid‐responsive
properties
HPM
enable
situ,
liposome
encapsulation,
significantly
ensuring
excellent
injectability
localized
therapeutic
effects.
As
proof
concept,
is
applied
as
skin
dressing,
controlled
release
improving
stratum
corneum
hydration,
thereby
markedly
transdermal
antioxidant
coenzyme
Q10
(CoQ10).
Compared
direct
application
free
CoQ10
dispersions,
achieves
impressive
16.6‐fold
increase
bioavailability,
highlighting
its
strong
potential
for
applications
disease
treatment.
