pH-sensitive phthalocyanine-loaded polymeric nanoparticles as a novel treatment strategy for breast cancer
Bioorganic Chemistry,
Год журнала:
2025,
Номер
155, С. 108127 - 108127
Опубликована: Янв. 4, 2025
Язык: Английский
Polymer–drug and polymer–protein conjugated nanocarriers: Design, drug delivery, imaging, therapy, and clinical applications
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Год журнала:
2024,
Номер
16(4)
Опубликована: Июль 1, 2024
Polymer-drug
conjugates
and
polymer-protein
have
been
pivotal
in
the
realm
of
drug
delivery
systems
for
over
half
a
century.
These
polymeric
drugs
are
characterized
by
conjugation
therapeutic
molecules
or
functional
moieties
to
polymers,
enabling
range
benefits
including
extended
circulation
times,
targeted
delivery,
controlled
release,
decreased
immunogenicity.
This
review
delves
into
recent
advancements
challenges
clinical
translations
preclinical
studies
polymer-drug
conjugates.
The
design
principles
functionalization
strategies
crucial
development
these
were
explored
followed
structural
properties
characteristics
various
polymer
carriers.
also
identifies
significant
obstacles
translation
provides
insights
directions
their
future
development.
article
is
categorized
under:
Therapeutic
Approaches
Drug
Discovery
>
Nanomedicine
Oncologic
Disease.
Язык: Английский
Diketopyrrolopyrrole-Based Nanoparticles with Near-Infrared Absorption for Tumor Photothermal Therapy
ACS Applied Nano Materials,
Год журнала:
2025,
Номер
8(4), С. 2054 - 2061
Опубликована: Янв. 17, 2025
Diketopyrrolopyrrole
(DPP)
is
now
widely
used
in
the
phototherapy
of
tumors,
but
most
reported
DPP
molecules
have
no
absorption
near-infrared
(NIR)
region.
In
this
study,
3
derivatives
with
donor–acceptor–donor
(D-A-D)
structures
were
designed
and
synthesized,
which
named
OODPP,
OSDPP,
SSDPP
according
to
number
thione
groups.
Their
spectra
are
gradually
red-shifted
an
increase
However,
after
preparation
nanoparticles
(NPs),
OSDPP
NPs
show
maximum
red
shift
peak
at
786
nm
excellent
photothermal
performance
under
NIR
laser
irradiation.
addition,
could
more
effectively
inhibit
tumor
growth
Therefore,
work
provides
a
feasible
method
for
design
DPP-based
phototherapeutic
agents
therapy.
Язык: Английский
提高光敏剂代谢或降解能力的分子策略（特邀）
武文博 Wu Wenbo,
王孔琛 Wang Kongchen
Chinese Journal of Lasers,
Год журнала:
2025,
Номер
52(3), С. 0307203 - 0307203
Опубликована: Янв. 1, 2025
Light-Responsive conjugated polymer nanoparticles with Spatial-Controlled camptothecin release via π − π stacking for improved Combinatorial therapy of breast cancer
Materials & Design,
Год журнала:
2024,
Номер
245, С. 113270 - 113270
Опубликована: Авг. 27, 2024
Язык: Английский
Microenvironment Responsive Biomineralization Nanofirework Employing H2S-Assisted Photothermal Therapy to Prompt Bacterial Wound Healing
ACS Applied Nano Materials,
Год журнала:
2024,
Номер
7(17), С. 20678 - 20689
Опубликована: Авг. 17, 2024
Infected
wounds
present
a
complex
challenge
characterized
by
the
dual
problems
of
bacterial
overgrowth
and
delayed
healing.
Conventional
treatments
have
yet
to
address
these
issues
concurrently
effectively.
In
response
this,
we
developed
nanofirework,
ZnS/CuS@BSA
(BSA,
bovine
serum
albumin),
synthesized
via
biomineralization
process.
This
nanocomposite
is
designed
for
hydrogen
sulfide
(H2S)-assisted
photothermal
therapy
(PTT)
targeting
infections
in
wounds.
Upon
exposure
808
nm
laser
irradiation,
CuS
component
nanofirework
efficiently
converts
light
energy
into
heat,
which
denatures
bacteria
wound.
Simultaneously,
acidic
environment
at
wound
site
catalyzes
controlled
release
H2S
from
ZnS
component.
released
not
only
inhibits
peroxidase
activity,
increases
levels
reactive
oxygen
species
(ROS),
but
also
enhances
cell
migration
proliferation,
accelerating
healing
Furthermore,
concurrent
zinc
ions
(Zn2+)
compromises
membrane
integrity,
enhancing
overall
antibacterial
efficacy
nanocomposite.
Both
vitro
vivo
studies
substantiated
capability
significantly
promote
proliferation
inhibit
growth,
thereby
facilitating
rapid
infected
innovative
approach,
integrating
with
PTT
through
biomineralized
offers
promising
antibiotic-free
strategy.
It
has
potential
enhance
treatment
wounds,
presenting
synergistic
antimicrobial
effect.
Язык: Английский
Semiconducting polymer nanoparticles for fluorescence biosensors and phototherapy: A review
European Polymer Journal,
Год журнала:
2024,
Номер
unknown, С. 113608 - 113608
Опубликована: Ноя. 1, 2024
Язык: Английский
The Current Advances in Design Strategy (Indirect Strategy and Direct Strategy) for Type‐I Photosensitizers
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 25, 2024
Type-I
photosensitizers
(PSs)
are
among
the
most
potential
candidates
for
photodynamic
therapy
(PDT),
as
their
low
dependence
on
oxygen
endow
them
with
many
advantages
treating
hypoxic
tumor.
However,
of
reported
type-I
PSs
have
a
contingency
molecular
design,
because
electron
transfer
(ET)
reaction
is
more
difficult
to
achieve
than
energy
(EET)
process.
Therefore,
it
urgent
understand
design
mechanisms
PSs.
In
this
review,
two
ways
PSs,
i.e.,
inhibiting
EET
process
(type-II)
or
enhancing
ET
(type-I),
detailly
explained.
response,
current
strategies
summarized
from
perspectives:
indirect
strategy
(inhibiting
process:
reducing
lowest
triplet
excited
state
(T
Язык: Английский
Off‐Photosensitizing Derived Immuno‐Photodynamic Therapy toward Postoperative Care
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 29, 2024
Abstract
Immuno‐photodynamic
therapy
(IPDT)
has
emerged
as
a
promising
cancer
treatment
strategy.
However,
conventional
IPDT
faces
challenges
related
to
post‐treatment
safety,
owing
the
use
of
residual
photosensitizers
(PSs).
In
this
study,
on
novel
H
2
O
‐responsive
aggregation‐induced
emission
PS
is
reported,
TBZPYBE
,
designed
selectively
target
cells
and
enhance
therapeutic
efficacy
postoperative
safety
IPDT.
Although
exhibits
weak
fluorescence,
strong
reactive
oxygen
species
(ROS)
are
produced
under
light
irradiation,
demonstrating
its
high
photodynamic
(PDT)
in
vitro
vivo.
Following
PDT,
underwent
self‐quenching
presence
converting
it
TBZPY,
which
fluorescence
but
reduced
ROS
generation.
Simultaneously,
quinone
methide,
glutathione
scavenger
that
amplifies
PDT
efficiency,
released.
Furthermore,
activated
immune
response
by
promoting
dendritic
cell
maturation
polarizing
M2
M1
macrophages.
The
observed
effects
can
be
attributed
tumor
selectivity,
mechanisms,
ability
trigger
responses,
offering
balanced
approach
with
improved
safety.
Язык: Английский
Biodegradable Semiconducting Polymer Nanoparticles for Phototheranostics
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 30, 2024
Semiconducting
polymer
nanoparticles
(SPNs)
have
been
widely
applied
for
phototheranostics.
However,
the
disadvantage
of
in
vivo
long-term
metabolism
greatly
suppresses
clinical
application
SPNs.
To
improve
metabolic
rate
and
minimize
toxicity
SPNs,
biodegradable
semiconducting
polymers
(BSPs),
whose
backbones
may
be
degraded
under
certain
conditions,
designed.
This
review
summarizes
recent
advances
BSP-constructed
(BSPNs)
BSPs
are
divided
into
two
categories:
conjugated
backbone
degradable
(CBD-BSPs)
non-conjugated
(NCBD-BSPs),
based
on
feature
chemical
structure.
The
biological
applications,
including
cancer
imaging
combination
therapy,
these
BSPNs
described.
Finally,
conclusion
future
perspectives
this
field
discussed.
Язык: Английский