Biodegradable Semiconducting Polymer Nanoparticles for Phototheranostics DOI
Wen Zhou, Qiang Li, Mingming Liu

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 30, 2024

Semiconducting polymer nanoparticles (SPNs) have been widely applied for phototheranostics. However, the disadvantage of in vivo long-term metabolism greatly suppresses clinical application SPNs. To improve metabolic rate and minimize toxicity SPNs, biodegradable semiconducting polymers (BSPs), whose backbones may be degraded under certain conditions, designed. This review summarizes recent advances BSP-constructed (BSPNs) BSPs are divided into two categories: conjugated backbone degradable (CBD-BSPs) non-conjugated (NCBD-BSPs), based on feature chemical structure. The biological applications, including cancer imaging combination therapy, these BSPNs described. Finally, conclusion future perspectives this field discussed.

Language: Английский

pH-sensitive phthalocyanine-loaded polymeric nanoparticles as a novel treatment strategy for breast cancer DOI
Katarzyna Malarz, Wioleta Borzęcka,

Patryk Zioła

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 155, P. 108127 - 108127

Published: Jan. 4, 2025

Language: Английский

Citations

1
Polymer–drug and polymer–protein conjugated nanocarriers: Design, drug delivery, imaging, therapy, and clinical applications DOI
Haochen Guo, Peng Mi

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2024, Volume and Issue: 16(4)

Published: July 1, 2024

Polymer-drug conjugates and polymer-protein have been pivotal in the realm of drug delivery systems for over half a century. These polymeric drugs are characterized by conjugation therapeutic molecules or functional moieties to polymers, enabling range benefits including extended circulation times, targeted delivery, controlled release, decreased immunogenicity. This review delves into recent advancements challenges clinical translations preclinical studies polymer-drug conjugates. The design principles functionalization strategies crucial development these were explored followed structural properties characteristics various polymer carriers. also identifies significant obstacles translation provides insights directions their future development. article is categorized under: Therapeutic Approaches Drug Discovery > Nanomedicine Oncologic Disease.

Language: Английский

Citations

4
Diketopyrrolopyrrole-Based Nanoparticles with Near-Infrared Absorption for Tumor Photothermal Therapy DOI
Ting Zheng, Hui Wen, Hongyu Wang

et al.

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: 8(4), P. 2054 - 2061

Published: Jan. 17, 2025

Diketopyrrolopyrrole (DPP) is now widely used in the phototherapy of tumors, but most reported DPP molecules have no absorption near-infrared (NIR) region. In this study, 3 derivatives with donor–acceptor–donor (D-A-D) structures were designed and synthesized, which named OODPP, OSDPP, SSDPP according to number thione groups. Their spectra are gradually red-shifted an increase However, after preparation nanoparticles (NPs), OSDPP NPs show maximum red shift peak at 786 nm excellent photothermal performance under NIR laser irradiation. addition, could more effectively inhibit tumor growth Therefore, work provides a feasible method for design DPP-based phototherapeutic agents therapy.

Language: Английский

Citations

0
提高光敏剂代谢或降解能力的分子策略（特邀） DOI

武文博 Wu Wenbo,

王孔琛 Wang Kongchen

Chinese Journal of Lasers, Journal Year: 2025, Volume and Issue: 52(3), P. 0307203 - 0307203

Published: Jan. 1, 2025

Citations

0
Light-Responsive conjugated polymer nanoparticles with Spatial-Controlled camptothecin release via π − π stacking for improved Combinatorial therapy of breast cancer DOI Creative Commons

Zhaokui Zeng,

Jingjing Tian, Wenjie Xu

et al.

Materials & Design, Journal Year: 2024, Volume and Issue: 245, P. 113270 - 113270

Published: Aug. 27, 2024

Language: Английский

Citations

2
Microenvironment Responsive Biomineralization Nanofirework Employing H2S-Assisted Photothermal Therapy to Prompt Bacterial Wound Healing DOI
Xianan Li, Hairui Deng,

Lingfeng Pan

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(17), P. 20678 - 20689

Published: Aug. 17, 2024

Infected wounds present a complex challenge characterized by the dual problems of bacterial overgrowth and delayed healing. Conventional treatments have yet to address these issues concurrently effectively. In response this, we developed nanofirework, ZnS/CuS@BSA (BSA, bovine serum albumin), synthesized via biomineralization process. This nanocomposite is designed for hydrogen sulfide (H2S)-assisted photothermal therapy (PTT) targeting infections in wounds. Upon exposure 808 nm laser irradiation, CuS component nanofirework efficiently converts light energy into heat, which denatures bacteria wound. Simultaneously, acidic environment at wound site catalyzes controlled release H2S from ZnS component. released not only inhibits peroxidase activity, increases levels reactive oxygen species (ROS), but also enhances cell migration proliferation, accelerating healing Furthermore, concurrent zinc ions (Zn2+) compromises membrane integrity, enhancing overall antibacterial efficacy nanocomposite. Both vitro vivo studies substantiated capability significantly promote proliferation inhibit growth, thereby facilitating rapid infected innovative approach, integrating with PTT through biomineralized offers promising antibiotic-free strategy. It has potential enhance treatment wounds, presenting synergistic antimicrobial effect.

Language: Английский

Citations

0
Semiconducting polymer nanoparticles for fluorescence biosensors and phototherapy: A review DOI

Zi Long,

Jianjun Gan, Xianglian Wang

et al.

European Polymer Journal, Journal Year: 2024, Volume and Issue: unknown, P. 113608 - 113608

Published: Nov. 1, 2024

Language: Английский

Citations

0
The Current Advances in Design Strategy (Indirect Strategy and Direct Strategy) for Type‐I Photosensitizers DOI Creative Commons
Ning Ma,

Junjie Wang,

Hui Tang

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 25, 2024

Type-I photosensitizers (PSs) are among the most potential candidates for photodynamic therapy (PDT), as their low dependence on oxygen endow them with many advantages treating hypoxic tumor. However, of reported type-I PSs have a contingency molecular design, because electron transfer (ET) reaction is more difficult to achieve than energy (EET) process. Therefore, it urgent understand design mechanisms PSs. In this review, two ways PSs, i.e., inhibiting EET process (type-II) or enhancing ET (type-I), detailly explained. response, current strategies summarized from perspectives: indirect strategy (inhibiting process: reducing lowest triplet excited state (T

Language: Английский

Citations

0
Off‐Photosensitizing Derived Immuno‐Photodynamic Therapy toward Postoperative Care DOI Open Access
Jing Li, E Pang, Jusung An

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 29, 2024

Abstract Immuno‐photodynamic therapy (IPDT) has emerged as a promising cancer treatment strategy. However, conventional IPDT faces challenges related to post‐treatment safety, owing the use of residual photosensitizers (PSs). In this study, on novel H 2 O ‐responsive aggregation‐induced emission PS is reported, TBZPYBE , designed selectively target cells and enhance therapeutic efficacy postoperative safety IPDT. Although exhibits weak fluorescence, strong reactive oxygen species (ROS) are produced under light irradiation, demonstrating its high photodynamic (PDT) in vitro vivo. Following PDT, underwent self‐quenching presence converting it TBZPY, which fluorescence but reduced ROS generation. Simultaneously, quinone methide, glutathione scavenger that amplifies PDT efficiency, released. Furthermore, activated immune response by promoting dendritic cell maturation polarizing M2 M1 macrophages. The observed effects can be attributed tumor selectivity, mechanisms, ability trigger responses, offering balanced approach with improved safety.

Language: Английский

Citations

0
Biodegradable Semiconducting Polymer Nanoparticles for Phototheranostics DOI
Wen Zhou, Qiang Li, Mingming Liu

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 30, 2024

Semiconducting polymer nanoparticles (SPNs) have been widely applied for phototheranostics. However, the disadvantage of in vivo long-term metabolism greatly suppresses clinical application SPNs. To improve metabolic rate and minimize toxicity SPNs, biodegradable semiconducting polymers (BSPs), whose backbones may be degraded under certain conditions, designed. This review summarizes recent advances BSP-constructed (BSPNs) BSPs are divided into two categories: conjugated backbone degradable (CBD-BSPs) non-conjugated (NCBD-BSPs), based on feature chemical structure. The biological applications, including cancer imaging combination therapy, these BSPNs described. Finally, conclusion future perspectives this field discussed.

Language: Английский

Citations

0