International Journal of Applied Pharmaceutics,
Год журнала:
2024,
Номер
unknown, С. 31 - 37
Опубликована: Сен. 7, 2024
Cancer
is
a
global
health
problem
of
human
beings
that
growing
day
by
despite
several
advancements
in
the
medical
field.
The
main
concern
cancer
treatment
timely
and
proper
diagnosis
this
disease
targeting
therapeutic
moieties
to
site.
Nanotechnology
has
emerged
as
boon
for
healthcare
system
treating
various
life-threatening
diseases.
Mesoporous
Silica
Nanoparticles
(MSNs),
have
drawn
interest
cancers
other
MSNs
can
be
easily
adjusted
specifically
target
cells,
improve
drug
minimize
undesirable
effects.
In
imaging
cancer,
altered
with
agents
or
used
contrast
techniques
like
Magnetic
Resonance
Imaging
(MRI)
Computed
Tomography
(CT).
deliver
different
types
molecules
alone
combinations
provide
synergistic
effect
eradicating
cancer.
current
review
focused
on
highlighting
role
combating
addition,
biodegradation,
clearance
toxicity
profile
explained
evaluate
their
suitability
clinical
applications.
ABSTRACT
The
swift
progression
of
bacterial
keratitis
necessitates
expeditious
therapeutic
intervention.
Present
methodologies
are
characterized
by
their
protracted
duration
and
invasiveness,
which
often
result
in
suboptimal
antibiotic
therapy.
Consequently,
there
is
an
imperative
requirement
for
the
development
novel
approaches
management
keratitis.
In
this
study,
we
present
two
types
XOFs
connected
[N···Br
+
···N]
interactions.
These
frameworks
were
using
1
H
NMR,
IR,
XPS,
SAXS,
HR‐TEM.
Two‐dimensional
(2D)
structural
models
established
based
on
PXRD
data
theoretical
simulations.
application
these
as
antibacterial
agents
treatment
explored,
effects
different
connection
knots
hydrophilicity
efficacy
compared.
As
expected,
effect
interactions
superior
to
[N···I
TPPA
‐based
with
good
better
than
TPPE
XOFs.
addition,
a
photothermal
agent
(IR820)
was
loaded
onto
XOF(Br)‐TPPA
combined
chemotherapy,
experimental
results
indicating
substantial
enhancement
efficacy.
This
work
not
only
deepens
our
understanding
halogen‐bonded
organic
but
also
paves
way
biomedical
materials.
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Март 6, 2025
Microbial
keratitis,
a
sight-threatening
corneal
infection,
remains
significant
global
health
concern.
Conventional
therapies
using
antimicrobial
agents
often
suffers
from
limitations
such
as
poor
drug
penetration,
side
effects,
and
occurrence
of
resistance,
with
prognosis.
Novel
treatment
techniques,
their
unique
properties
targeted
delivery
capabilities,
offers
promising
solution
to
overcome
these
challenges.
This
review
delves
into
timely
update
the
state-of-the-art
advance
therapeutics
for
keratitis
treatment.
The
diverse
microbial
origins
including
viral,
bacterial,
fungal
infections,
exploring
complex
pathogenic
mechanisms,
followed
by
resistance
mechanisms
in
pathogens
are
reviewed
briefly.
Importantly,
emerging
therapeutic
techniques
piezodynamic
therapy,
photothermal
photodynamic
nanoenzyme
metal
ion
therapy
summarized
this
showcasing
potential
traditional
treatments.
challenges
future
directions
nanotechnology-based
approaches
discussed,
focusing
on
safety,
targeting
strategies,
combination
therapies.
aims
inspire
researchers
revolutionize
accelerate
development
functional
materials
different
International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 4551 - 4569
Опубликована: Апрель 1, 2025
Fungal
keratitis
is
a
severe
vision-threatening
corneal
infection
with
prognosis
influenced
by
fungal
virulence
and
the
host's
immune
defense
mechanisms.
However,
there
still
lack
of
effective
drugs
that
attenuate
while
relieving
inflammatory
response
caused
keratitis.
Finding
an
treatment
to
solve
these
problems
particularly
important.
We
synthesized
Zeolitic
imidazolate
framework-90
(ZIF-90)
water-based
synthesis
method
characterized
it.
In
vitro
experiments
included
mycelium
electron
microscopy,
Cell
Counting
Kit-8
(CCK-8),
Enzyme-linked
immunosorbent
assay
(ELISA).
These
trials
verified
disruptive
effects
ZIF-90
on
morphology,
cell
membrane,
wall,
biofilm
formation
Aspergillus
fumigatus
(A.
fumigatus).
also
demonstrated
impact
proinflammatory
cytokines
tumor
necrosis
factor-α
(TNF-α)
interleukin-6
(IL-6).
Moreover,
effect
mitochondrial
reactive
oxygen
species
(mtROS)
cells
fungi
was
MitoSOX
Red
Mitochondrial
Superoxide
Indicator
(MitoSOX).
vivo,
toxicity
test,
establishment
mycotic
mouse
model,
immunofluorescence
staining
were
used
evaluate
efficacy
in
procedure
addition,
investigate
whether
metal-ligand
zinc
organic
ligand
imidazole
acted
as
essential
factors
ZIF-90,
we
investigated
antimicrobial
anti-inflammatory
ZIF-8,
ZIF-67
Metal-Organic
Frameworks-74
(Zn)
(MOF-74
(Zn))
Minimum
Inhibitory
Concentration
(MIC)
ELISA
experiments.
has
therapeutic
keratitis,
which
could
break
protective
organelles
A.
fumigatus,
such
wall.
can
be
targeted
increase
amount
mtROS
promote
apoptosis
macrophages.
The
results
both
ions
possessed
effects.
exhibited
better
antifungal
properties
than
ZIF-67,
MOF-74
(Zn).
Nanomaterials,
Год журнала:
2025,
Номер
15(10), С. 754 - 754
Опубликована: Май 17, 2025
Zinc
oxide
nanoparticles
(ZnO
NPs)
have
garnered
significant
attention
across
various
scientific
and
technological
domains
due
to
their
unique
physicochemical
properties,
including
high
surface
area,
photostability,
biocompatibility,
potent
antimicrobial
activity.
These
attributes
make
ZnO
NPs
highly
versatile,
enabling
application
in
biomedicine,
environmental
science,
industry,
agriculture.
They
serve
as
effective
agents
medical
treatments
catalysts
purification
processes,
owing
ability
generate
reactive
oxygen
species
(ROS)
exhibit
photocatalytic
activity
under
UV
light.
Moreover,
are
being
increasingly
employed
advanced
drug
delivery
systems
cancer
therapies,
highlighting
potential
modern
medicine.
Their
growing
popularity
is
further
supported
by
ease
of
synthesis,
cost-effectiveness,
capacity
for
diverse
functionalization,
which
expand
utility
multiple
sectors.
This
review
focuses
on
research
from
the
past
five
years
(2020–2025)
practical
uses
biomedical,
environmental,
industrial,
agricultural
fields.
It
also
highlights
current
trends,
existing
challenges,
future
perspectives.
By
examining
these
aspects,
article
provides
a
comprehensive
understanding
versatile
roles
emerging
significance
science
technology.
