Therapeutic Efficacy of a Synthetic Brain-Targeted H2S Donor Cross-Linked Nanomicelle in Autism Spectrum Disorder Rats through Aerobic Glycolysis DOI
Changmei Zhang,

Lingyuan Yang,

Feng Wang

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 17(1), С. 157 - 173

Опубликована: Дек. 18, 2024

Autism spectrum disorder (ASD) is characterized by cognitive inflexibility and social deficits, with a notably limited range of brain-targeted medications, particularly in the field nanomedicine. Herein, we introduce H2S donor cross-linked nanomicelle, named mannose-PEG600-lipoic acid (Man-LA). Man-LA demonstrates enhanced stability precise brain delivery interacting glucose transporter 1 (GLUT1) astrocytes, facilitating gradual release that modulated glutathione (GSH). In vivo, studies suggest alleviates symptoms ASD, correlating increased expression aerobic glycolysis enzymes, elevated lactate production, higher levels, while preventing damage to hippocampal neurons. vitro, tightly binds aldehyde dehydrogenase family 3 member B1 (Aldh3b1) upregulating its expression. This interaction promotes enhances production. These findings connection between ASD deficits dysregulation astrocytic glycolysis, underscoring role H2S. Identifying Aldh3b1 gene within pathways provides promising target for treatment.

Язык: Английский

Chitosan nanoparticles in tumor imaging and therapy DOI

Shima Zahed Nasab,

Babak Akbari, Ebrahim Mostafavi

и другие.

Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 405 - 445

Опубликована: Ноя. 29, 2024

Язык: Английский

Процитировано

0
Therapeutic Efficacy of a Synthetic Brain-Targeted H2S Donor Cross-Linked Nanomicelle in Autism Spectrum Disorder Rats through Aerobic Glycolysis DOI
Changmei Zhang,

Lingyuan Yang,

Feng Wang

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 17(1), С. 157 - 173

Опубликована: Дек. 18, 2024

Autism spectrum disorder (ASD) is characterized by cognitive inflexibility and social deficits, with a notably limited range of brain-targeted medications, particularly in the field nanomedicine. Herein, we introduce H2S donor cross-linked nanomicelle, named mannose-PEG600-lipoic acid (Man-LA). Man-LA demonstrates enhanced stability precise brain delivery interacting glucose transporter 1 (GLUT1) astrocytes, facilitating gradual release that modulated glutathione (GSH). In vivo, studies suggest alleviates symptoms ASD, correlating increased expression aerobic glycolysis enzymes, elevated lactate production, higher levels, while preventing damage to hippocampal neurons. vitro, tightly binds aldehyde dehydrogenase family 3 member B1 (Aldh3b1) upregulating its expression. This interaction promotes enhances production. These findings connection between ASD deficits dysregulation astrocytic glycolysis, underscoring role H2S. Identifying Aldh3b1 gene within pathways provides promising target for treatment.

Язык: Английский

Процитировано

0