Therapeutic Efficacy of a Synthetic Brain-Targeted H2S Donor Cross-Linked Nanomicelle in Autism Spectrum Disorder Rats through Aerobic Glycolysis DOI
Changmei Zhang,

Lingyuan Yang,

Feng Wang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 17(1), P. 157 - 173

Published: Dec. 18, 2024

Autism spectrum disorder (ASD) is characterized by cognitive inflexibility and social deficits, with a notably limited range of brain-targeted medications, particularly in the field nanomedicine. Herein, we introduce H2S donor cross-linked nanomicelle, named mannose-PEG600-lipoic acid (Man-LA). Man-LA demonstrates enhanced stability precise brain delivery interacting glucose transporter 1 (GLUT1) astrocytes, facilitating gradual release that modulated glutathione (GSH). In vivo, studies suggest alleviates symptoms ASD, correlating increased expression aerobic glycolysis enzymes, elevated lactate production, higher levels, while preventing damage to hippocampal neurons. vitro, tightly binds aldehyde dehydrogenase family 3 member B1 (Aldh3b1) upregulating its expression. This interaction promotes enhances production. These findings connection between ASD deficits dysregulation astrocytic glycolysis, underscoring role H2S. Identifying Aldh3b1 gene within pathways provides promising target for treatment.

Language: Английский

Chitosan nanoparticles in tumor imaging and therapy DOI

Shima Zahed Nasab,

Babak Akbari, Ebrahim Mostafavi

et al.

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 405 - 445

Published: Nov. 29, 2024

Language: Английский

Citations

0
Therapeutic Efficacy of a Synthetic Brain-Targeted H2S Donor Cross-Linked Nanomicelle in Autism Spectrum Disorder Rats through Aerobic Glycolysis DOI
Changmei Zhang,

Lingyuan Yang,

Feng Wang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 17(1), P. 157 - 173

Published: Dec. 18, 2024

Autism spectrum disorder (ASD) is characterized by cognitive inflexibility and social deficits, with a notably limited range of brain-targeted medications, particularly in the field nanomedicine. Herein, we introduce H2S donor cross-linked nanomicelle, named mannose-PEG600-lipoic acid (Man-LA). Man-LA demonstrates enhanced stability precise brain delivery interacting glucose transporter 1 (GLUT1) astrocytes, facilitating gradual release that modulated glutathione (GSH). In vivo, studies suggest alleviates symptoms ASD, correlating increased expression aerobic glycolysis enzymes, elevated lactate production, higher levels, while preventing damage to hippocampal neurons. vitro, tightly binds aldehyde dehydrogenase family 3 member B1 (Aldh3b1) upregulating its expression. This interaction promotes enhances production. These findings connection between ASD deficits dysregulation astrocytic glycolysis, underscoring role H2S. Identifying Aldh3b1 gene within pathways provides promising target for treatment.

Language: Английский

Citations

0