Multimodal Photodynamic Therapy by Inhibiting the Nrf2/ARE Signaling Pathway in Tumors DOI
Xin Duan, Bingjian Xue,

Zimeng Xu

и другие.

ACS Biomaterials Science & Engineering, Год журнала: 2024, Номер 10(11), С. 7018 - 7029

Опубликована: Окт. 17, 2024

Photodynamic therapy (PDT) has been widely used in the clinical of various tumors, especially superficial tumors. However, tumor microenvironment presents hypoxia, as well inherent antioxidant system (e.g., Nrf2) cells limits therapeutic outcomes. Herein, a cascade-responsive "oxidative stress amplifier" (named EZ@TD) is designed by encapsulating manganese-doped carbon dots acting photosensitizer and catalase (CAT)-like nanozyme within pH-sensitive ZIF-8 Zn2+-activated DNAzyme for relieving hypoxia efficient Nrf2 gene disruption to enhance PDT. It demonstrated that EZ@TD synergistically inhibited growth activated antitumor immune response inhibiting Nrf2/ARE signaling pathway We provide new paradigm amplifying intracellular oxidative interfering with pathways.

Язык: Английский

Therapeutic application of nanosystems-based metalloptosis for enhanced tumor radiotherapy DOI

Meili Chen,

Ling Chen,

Kun Mao

и другие.

Coordination Chemistry Reviews, Год журнала: 2025, Номер 536, С. 216666 - 216666

Опубликована: Апрель 10, 2025

Язык: Английский

Процитировано

0
A hyaluronic acid Schiff base @ hollow calcium peroxide @ copper carbon dots nanoconjugate enhances chemodynamic tumor therapy based on multiple approaches strategy DOI
Xu Zhu, Yuting Lu, Minghao Sun

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 311, С. 144039 - 144039

Опубликована: Май 9, 2025

Язык: Английский

Процитировано

0
Multimodal Photodynamic Therapy by Inhibiting the Nrf2/ARE Signaling Pathway in Tumors DOI
Xin Duan, Bingjian Xue,

Zimeng Xu

и другие.

ACS Biomaterials Science & Engineering, Год журнала: 2024, Номер 10(11), С. 7018 - 7029

Опубликована: Окт. 17, 2024

Photodynamic therapy (PDT) has been widely used in the clinical of various tumors, especially superficial tumors. However, tumor microenvironment presents hypoxia, as well inherent antioxidant system (e.g., Nrf2) cells limits therapeutic outcomes. Herein, a cascade-responsive "oxidative stress amplifier" (named EZ@TD) is designed by encapsulating manganese-doped carbon dots acting photosensitizer and catalase (CAT)-like nanozyme within pH-sensitive ZIF-8 Zn2+-activated DNAzyme for relieving hypoxia efficient Nrf2 gene disruption to enhance PDT. It demonstrated that EZ@TD synergistically inhibited growth activated antitumor immune response inhibiting Nrf2/ARE signaling pathway We provide new paradigm amplifying intracellular oxidative interfering with pathways.

Язык: Английский

Процитировано

0