Multimodal Photodynamic Therapy by Inhibiting the Nrf2/ARE Signaling Pathway in Tumors DOI
Xin Duan, Bingjian Xue,

Zimeng Xu

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(11), P. 7018 - 7029

Published: Oct. 17, 2024

Photodynamic therapy (PDT) has been widely used in the clinical of various tumors, especially superficial tumors. However, tumor microenvironment presents hypoxia, as well inherent antioxidant system (e.g., Nrf2) cells limits therapeutic outcomes. Herein, a cascade-responsive "oxidative stress amplifier" (named EZ@TD) is designed by encapsulating manganese-doped carbon dots acting photosensitizer and catalase (CAT)-like nanozyme within pH-sensitive ZIF-8 Zn2+-activated DNAzyme for relieving hypoxia efficient Nrf2 gene disruption to enhance PDT. It demonstrated that EZ@TD synergistically inhibited growth activated antitumor immune response inhibiting Nrf2/ARE signaling pathway We provide new paradigm amplifying intracellular oxidative interfering with pathways.

Language: Английский

Therapeutic application of nanosystems-based metalloptosis for enhanced tumor radiotherapy DOI

Meili Chen,

Ling Chen,

Kun Mao

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 536, P. 216666 - 216666

Published: April 10, 2025

Language: Английский

Citations

0
A hyaluronic acid Schiff base @ hollow calcium peroxide @ copper carbon dots nanoconjugate enhances chemodynamic tumor therapy based on multiple approaches strategy DOI
Xu Zhu, Yuting Lu, Minghao Sun

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 311, P. 144039 - 144039

Published: May 9, 2025

Language: Английский

Citations

0
Multimodal Photodynamic Therapy by Inhibiting the Nrf2/ARE Signaling Pathway in Tumors DOI
Xin Duan, Bingjian Xue,

Zimeng Xu

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(11), P. 7018 - 7029

Published: Oct. 17, 2024

Photodynamic therapy (PDT) has been widely used in the clinical of various tumors, especially superficial tumors. However, tumor microenvironment presents hypoxia, as well inherent antioxidant system (e.g., Nrf2) cells limits therapeutic outcomes. Herein, a cascade-responsive "oxidative stress amplifier" (named EZ@TD) is designed by encapsulating manganese-doped carbon dots acting photosensitizer and catalase (CAT)-like nanozyme within pH-sensitive ZIF-8 Zn2+-activated DNAzyme for relieving hypoxia efficient Nrf2 gene disruption to enhance PDT. It demonstrated that EZ@TD synergistically inhibited growth activated antitumor immune response inhibiting Nrf2/ARE signaling pathway We provide new paradigm amplifying intracellular oxidative interfering with pathways.

Language: Английский

Citations

0