Nano-Structures & Nano-Objects, Год журнала: 2024, Номер 38, С. 101117 - 101117
Опубликована: Апрель 23, 2024
Язык: Английский
Green Processing and Synthesis, Год журнала: 2024, Номер 13(1)
Опубликована: Янв. 1, 2024
Abstract Materials-based drug delivery approaches have garnered substantial attention in recent years due to their potential revolutionize pharmaceutical interventions. This abstract provides a concise overview of advancements and future prospects this rapidly evolving field. Materials such as nanoparticles, liposomes, polymers, hydrogels emerged versatile carriers for delivery. These materials facilitate precise control over release kinetics, enabling targeted sustained therapeutic effects. Smart with responsiveness external stimuli or physiological conditions further enhanced precision. Personalized medicine are gaining traction, tailoring systems individual patient profiles needs. The horizon materials-based is bright. Ongoing research focused on refining material design, streamlining production processes, ensuring safety profiles. Collaborative efforts among researchers, clinicians, industry stakeholders crucial translating these into clinical practice. Additionally, the convergence diagnostics imaging holds immense personalized efficient healthcare solutions. As continues evolve, it stands poised reshape landscape pharmaceuticals, offering promise more effective patient-centered therapies wide range medical conditions.
Язык: Английский
Процитировано
20
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Янв. 31, 2025
Nanotechnology has witnessed remarkable advancements in recent years, capturing considerable attention diverse biomedical applications. Using the green precipitation method, this study aims to synthesize and characterize chitosan/polyvinyl alcohol-copper oxide nanocomposites (CS/PVA/CuONCs) using Anacardium occidentale plant fruit extract. The CS/PVA/CuONCs were further evaluated antioxidant, antibacterial biological activities. In our results, UV-Vis spectrum analysis of revealed a peak at 430 nm. FTIR analyses confirmed presence different functional groups, while XRD crystalline structure synthesized nanocomposites. FESEM-EDAX demonstrated that exhibited spherical rod-like shape, with an average particle size 48.6 96.2 Notably, higher antioxidant activity, as evidenced by their ABTS activity (83.79 ± 1.57%) SOD (86.17 1.28%). assays, inhibition Escherichia coli 20.52 0.85 mm Bacillus subtilis 19.64 0.87 mm, displaying zone inhibition. excellent anti-inflammatory potency against COX-1 (67.10 0.58%) COX-2 (76.39 0.65%). antidiabetic assay α-amylase (80.25 1.29%) α-glucosidase (84.74 1.42%) Anti-cholinergic AChE was 65.35 0.98% BuChE 82.46 1.15% are observed. shown have strong cytotoxicity MCF-7 cell lines. It also had highest viability inhibition, 13.66 0.58%. hemolysis found be 5.38 0.34%. Overall, possess remarkably
Язык: Английский
Процитировано
4
Polymers, Год журнала: 2025, Номер 17(4), С. 435 - 435
Опубликована: Фев. 7, 2025
Drug delivery systems have revolutionized traditional drug administration methods by addressing various challenges, such as enhancing solubility, prolonging effectiveness, minimizing adverse effects, and preserving potency. Nanotechnology-based systems, particularly nanoparticles (NPs) nanofibers (NFs), emerged promising solutions for biomedicine delivery. NFs, with their ability to mimic the porous fibrous structures of biological tissues, garnered significant interest in drug-delivering applications. Biopolymers gelatin (Ge) chitosan (CH) gained much more attention due biocompatibility, biodegradability, versatility biomedical CH exhibits exceptional anti-bacterial activity, wound healing capabilities, whereas Ge provides good biocompatibility cell adhesion properties. Ge/CH-based NFs stimulate cellular connections facilitate tissue regeneration owing structural resemblance extracellular matrix. This review explores additive preparation, including electrospinning, force pinning, template synthesis, focusing on electrospinning factors influencing fiber structure. The properties CH, role release, formulation strategies, characterization techniques electrospun fibers are discussed. Furthermore, this addresses applications delivering active moieties management orthopedics regulatory considerations, along challenges related them. Thus, aims provide a comprehensive overview potential
Язык: Английский
Процитировано
3
Pharmaceutics, Год журнала: 2022, Номер 14(7), С. 1326 - 1326
Опубликована: Июнь 23, 2022
Quercetin is one of the most important plant flavanols, having several pharmacological and biological uses. (Q) an extremely hydrophobic phytochemical has poor intracellular absorption, which makes its use limited. Present research demonstrates that quercetin-loaded PLGA nanoparticles (PLGA-QNPs) could overcome low hydrophilicity improve anti-cancer potential. loaded with Q were prepared by solvent evaporation technique anticancer activity was examined in vitro as well vivo. The cell viability assessed through MTT assay apoptosis assayed Hoechst-PI EB/AO double staining followed mitochondrial damage Mito-tracker RMX-Ros. Gene expression RT-PCR. Cell cycle arrest G2/M phase analyzed FACS. results obtained revealed PLGA-QNPs significantly reduced human cervical breast cancer lines. induced cells a dose dependent manner. gene PI3K/AKT down-regulated FoxO1 upregulated PLGA-QNP-treated cells, showed high level active Caspase-3 7, are responsible for apoptosis. In addition, average number tumors prolonged tumor latency period DMBA-induced mammary adenocarcinoma SD rats. These findings suggest inhibit progression via 7 independent activation concomitant suppression pathway. For future studies, we potential druggability efficacy clinical development need to be evaluated intensely successful drug development.
Язык: Английский
Процитировано
48
European Journal of Medicinal Chemistry, Год журнала: 2023, Номер 259, С. 115676 - 115676
Опубликована: Июль 23, 2023
Язык: Английский
Процитировано
42
Journal of nanostructure in chemistry, Год журнала: 2022, Номер 13(2), С. 243 - 261
Опубликована: Янв. 4, 2022
Язык: Английский
Процитировано
39
Chemosphere, Год журнала: 2022, Номер 302, С. 134746 - 134746
Опубликована: Апрель 27, 2022
Язык: Английский
Процитировано
39
Plants, Год журнала: 2023, Номер 12(4), С. 815 - 815
Опубликована: Фев. 11, 2023
Climate change is more likely to have a detrimental effect on the world's productive assets. Several undesirable conditions and practices, including extreme temperature, drought, uncontrolled use of agrochemicals, result in stresses that strain agriculture. In addition, nutritional inadequacies food crops are wreaking havoc human health, especially rural regions less developed countries. This could be because plants unable absorb nutrients conventional fertilizers, or these fertilizers an inappropriate unbalanced nutrient composition. Chemical been used for centuries considerably increased crop yields. However, they also disrupt soil quality structure, eventually impacting entire ecosystem. To address situation, it necessary develop advanced materials can release targeted points plant-soil environment appropriate receptors leaf case foliar applications. Recently, nanotechnology-based interventions strongly encouraged meet growing demand promote security environmentally friendly manner. Biological approaches synthesis nanoscale agro-materials become promising area research, with wide range product types such as nanopesticides, nanoinsecticides, nanoherbicides, nanobactericides/fungicides, bio-conjugated nanocomplexes, nanoemulsions emerging therefrom. These sustainable target-oriented than agrochemicals. this paper, we reviewed literature major abiotic biotic plant growth productivity. We comprehensively discussed different forms provided overview biological nano-enabled strategies efficiently alleviate while potentially enhancing values plants.
Язык: Английский
Процитировано
38
European journal of medical research, Год журнала: 2023, Номер 28(1)
Опубликована: Ноя. 24, 2023
Abstract This paper gives a detailed analysis of nanotechnology's rising involvement in numerous surgical fields. We investigate the use nanotechnology orthopedic surgery, neurosurgery, plastic oncology, heart vascular ophthalmic thoracic and minimally invasive surgery. The details how helps with arthroplasty, chondrogenesis, tissue regeneration, wound healing, more. It also discusses employment nanomaterials implant surfaces, bone grafting, breast implants, among other things. article explores various uses, including stem cell-incorporated nano scaffolds, nano-surgery, hemostasis, nerve nanorobots, diagnostic applications. ethical safety implications using surgery are addressed. future possibilities investigated, pointing to possible route for improved patient outcomes. essay finishes comment on transformational influence applications its promise breakthroughs. Graphical
Язык: Английский
Процитировано
38
Journal of Polymer Science, Год журнала: 2023, Номер 61(7), С. 521 - 533
Опубликована: Фев. 8, 2023
Abstract Over the last few years, traditional drug delivery systems (DDSs) have been transformed into smart DDSs. Recent advancements in biomedical nanotechnology resulted introducing stimuli‐responsiveness to vehicles. Nanoplatforms can enhance release efficacy while reducing side effects of drugs by taking advantage responses specific internal or external stimuli. In this study, we developed an electrospun nanofibrous photo‐responsive The photo‐responsivity platform enables on‐demand elevated release. Furthermore, it provide a sustained profile and prevent burst high concentrations drugs. A coaxial electrospinning setup paired with electrospraying technique is used fabricate core‐shell PVA‐PLGA nanofibers decorated plasmonic nanoparticles. fabricated hydrophilic PVA Rhodamine‐B (RhB) core, shell hydrophobic PLGA gold nanorods (Au NRs). presence nanoparticles twice amount besides exhibiting long‐term Investigations mechanism demonstrate system's potential as “smart” platform.
Язык: Английский
Процитировано
28