Natural Product Research, Год журнала: 2024, Номер unknown, С. 1 - 15
Опубликована: Окт. 28, 2024
is a medicinal plant widely studied due to its great phytochemical diversity, especially acrinonic alkaloids, which have shown be promising anticancer candidates. The aim of this work was promote the isolation acridonic alkaloids from fruits
Язык: Английский
Journal of Drug Delivery Science and Technology, Год журнала: 2023, Номер 81, С. 104304 - 104304
Опубликована: Фев. 28, 2023
A hydrogel nanocomposite comprising polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), and titanium oxide (TiO2) was prepared encapsulated in a double emulsion as pH-triggered delivery vehicle for quercetin (QC), an antitumor drug. Dynamic light scattering (DLS) used to estimate the size confirm stability of QC-loaded nanoparticles. The interactions between components, its crystalline structure morphology nanoparticles were characterized through Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD) field emission scanning electron microscopy (FESEM), respectively. Drug loading encapsulation efficiency significantly improved after incorporation TiO2, which corroborates beneficial effect this component. In vitro release experiments indicated pH-responsivity nanocarrier, with higher amount QC released acidic medium than at neutral pH. Due presence emulsion, pattern sustained gradual both environments. Cellular including MTT assay flow cytometry conducted using U87 cell line compare anticancer activity free also performed on noncancerous (L929) assess potential side effects drug system. results obtained herein suitability developed nanocarrier efficient tumor therapy.
Язык: Английский
Процитировано
43
International Journal of Biological Macromolecules, Год журнала: 2023, Номер 232, С. 123437 - 123437
Опубликована: Янв. 26, 2023
Язык: Английский
Процитировано
36
Journal of Nanobiotechnology, Год журнала: 2023, Номер 21(1)
Опубликована: Май 6, 2023
Abstract Nanobiotechnology, as a novel and more specialized branch of science, has provided number nanostructures such nanoparticles, by utilizing the methods, techniques, protocols other branches science. Due to unique features physiobiological characteristics, these or nanocarriers have vast methods therapeutic against microbial infections cancers for tissue regeneration, engineering, immunotherapies, gene therapies, through drug delivery systems. However, reduced carrying capacity, abrupt non-targeted delivery, solubility agents, can affect applications biotechnological products. In this article, we explored discussed prominent nanobiotechnological products nanocarriers, highlighted challenges associated with products, attempted conclude if available offer any scope improvement enhancement. We aimed identify emphasize greater prospect capacity improvements enhancements. found that nanostructures, nanocomposites, micelles, hydrogels, microneedles, artificial cells, address inherited drawbacks, help conjugations, sustained stimuli-responsive release, ligand binding, targeted delivery. recommend nanobiotechnology, despite having few offers immense opportunities be harnessed in delivering quality therapeutics precision prediction. also that, exploring branched domains rigorously, bottlenecks obstacles addressed resolved return. Graphical
Язык: Английский
Процитировано
35
Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106968 - 106968
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
1
Frontiers in Biomaterials Science, Год журнала: 2023, Номер 2
Опубликована: Июнь 2, 2023
Cancer is one of the most life-threatening family diseases that cause death worldwide. As a highly researched and successful therapeutic agent, methotrexate (MTX) treats many solid tumours, hematologic malignancies, autoimmune illnesses. Despite benefits, induces drug resistance limits plasma half-life due to its poor pharmacokinetics. The variable biological availability have prompted researchers investigate innovative delivery strategies for enhancing qualities. To develop more suitable formulations, nanoparticles (NPs) recently gained significant interest. A wide range nanoparticles, including polymer-based carbon-based lipid-based as well inorganic can be deliver cancer chemotherapeutics such methotrexate. Loading into NPs provide system has shown great promise carcinoma therapy. In this review, we will describe feasibility NP-based in therapy, outlining current state art challenges/promises future.
Язык: Английский
Процитировано
16
OpenNano, Год журнала: 2023, Номер 13, С. 100175 - 100175
Опубликована: Июль 25, 2023
Язык: Английский
Процитировано
16
Inorganic Chemistry Communications, Год журнала: 2023, Номер 158, С. 111494 - 111494
Опубликована: Сен. 25, 2023
Язык: Английский
Процитировано
12
Journal of Materials Chemistry B, Год журнала: 2023, Номер 12(2), С. 448 - 465
Опубликована: Дек. 8, 2023
A series of near-infrared fluorescent probes, labeled to E, were developed by combining electron-rich thiophene and 3,4-ethylenedioxythiophene bridges with 3-quinolinium various electron deficient groups, enabling the sensing NAD(P)H. Probes B exhibit absorptions emissions in range, offering advantages such as minimal interference from autofluorescence, negligible photo impairment cells tissues, exceptional tissue penetration. These probes show fluorescence when NADH is not present, their absorption maxima are at 438 nm 470 nm, respectively. In contrast, C-E feature 450, 334 581 Added triggers transformation electron-deficient units into 1,4-dihydroquinoline resulting responses which established 748, 730, 575, 625 661 for AH-EH, respectively, detection limits 0.15 μM 0.07 B, Optimized geometries based on theoretical calculations reveal non-planar A-E due twisting benzothiazolium bonded central group, all attain planarity upon addition hydride near-IR region AH BH contrast CH-EH depict visible range. Probe has been successfully employed monitor NAD(P)H levels glycolysis specific mitochondrial targeting. Furthermore, it used assess influence lactate pyruvate NAD(P)H, explore how hypoxia cancer can elevate visualize changes under hypoxic conditions CoCl
Язык: Английский
Процитировано
12
Computational and Theoretical Chemistry, Год журнала: 2024, Номер 1232, С. 114461 - 114461
Опубликована: Янв. 6, 2024
Язык: Английский
Процитировано
5
ACS Omega, Год журнала: 2024, Номер 9(17), С. 19627 - 19636
Опубликована: Апрель 22, 2024
Metal-organic frameworks (MOFs) are utilized as nanocarriers to enhance the efficiency of chemotherapy drugs, including cisplatin, which exhibit limitations such side effects and resistance mechanisms. To evaluate role MOFs, we employed a molecular dynamics simulation, which, unlike other experiments, is cost-effective, less dangerous, provides accurate results. Furthermore, conducted docking simulations understand interaction between cisplatin MOF, well their internal interactions how they bind each other. Cisplatin MOF molecules were parametrized using Avogadro software x2top command in GROMACS 5.1.2 optimized by CP2K software; Charmm-GUI site cell cancer membrane. Three four stages at various pHs, followed simulated umbrella sampling. The analyzed pH responsiveness, total energy, Gibbs free gyration radius, radial distribution function (RDF), solvent accessible surface area, nanoparticles' toxicity. Results demonstrated that neutral level (7.4) has greater adsorption compared acidic values (6.4 5.4) because it displays highest energy (-17.1 kJ/mol), RDF value (6.66), shortest distance (0.51 nm). combination MOFs displayed increased penetration individual forms. This study highlights suitability identifies optimal for desirable outcomes. Thus, future studies with appropriate data conduct experiments assessing MOFs.
Язык: Английский
Процитировано
5