Journal of Porous Materials, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 20, 2024
Язык: Английский
Next Materials, Год журнала: 2024, Номер 2, С. 100128 - 100128
Опубликована: Янв. 1, 2024
This article is an overview of the current state nanoparticles because their emerging usage in cancer treatment, covering that have been authorized for use therapy currently undergoing clinical testing. Recent advances nanoparticle engineering, coupled with enhanced understanding critical attributes (size, shape, and surface properties) conjunction biological systems, present novel prospects therapeutic development. Although inorganic metallic are gaining recognition studies due to potential usefulness but nanomaterials primarily polymeric, liposomal, nano crystal based dominate therapy. Polymeric (NPs) contain specific ligands, such as polyglycolic acid (PGA) polylactic (PLA), which a chemical affinity malignant cells target tumors. Nanocrystals stand out high loading efficiency, stability, extended drug release, capacity deliver poorly soluble medications. The limitations conventional chemotherapy overcome variety applications improved care by metal-based nanoparticles, either used alone or combination. dynamic nature nanotechnology drives continued developments like protein-based micelles. Polymer lipid encapsulation within nanocrystals becoming more popular, suggesting long-term trend. advancement marks significant breakthrough life-saving nanotechnology, particularly sets stage pioneering nanomedicine.
Язык: Английский
Процитировано
28
Medical Oncology, Год журнала: 2023, Номер 40(12)
Опубликована: Ноя. 6, 2023
Язык: Английский
Процитировано
14
International Journal of Pharmaceutics, Год журнала: 2024, Номер 655, С. 124077 - 124077
Опубликована: Апрель 1, 2024
Developing drug delivery systems (DDSs) is one of the approaches used to improve cancer treatment, with main goal loading drugs into a carrier targeting specific organ and avoiding distribution healthy tissues. Nanoparticles (NPs) have been shown be optimum carriers that can as DDSs. Lipid-based NPs, such liposomes, investigated in current study due their low toxicity ability carry hydrophilic hydrophobic molecules. In studies, conventional liposomes composed DPPC, cholesterol PEGylated cholesterol, DSPE-PEG2000 are manufactured loaded Carboplatin. The focused on investigating comparing impact modifying carboplatin-loaded different concentrations NP diameter, polydispersity, ζ-potential, encapsulation efficiency (EE%), release. hydrodynamic microfluidic system was investigate any possible improvement EE% over other methods. results showed system's promising effect enhancing Moreover, smaller diameter higher stability liposome. However, represent better homogeneity for
Язык: Английский
Процитировано
5
International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 5059 - 5070
Опубликована: Май 1, 2024
The purpose of this study is to address the need for efficient drug delivery with high encapsulation efficiency and sustained release. We aim create nanoparticle-loaded microgels potential applications in treatment development.
Язык: Английский
Процитировано
4
Coatings, Год журнала: 2025, Номер 15(4), С. 489 - 489
Опубликована: Апрель 20, 2025
The recurrence of bone cancer poses severe complications, particularly after orthopedic surgery, necessitating advanced biomaterials with dual functionality. This study develops nanostructured coatings composed hydroxyapatite, carboplatin, and quercetin, designed to enhance regeneration while delivering localized therapy. These present a promising solution for hip endoprostheses, addressing osteointegration tumor prevention simultaneously. Hydroxyapatite was synthesized characterized using XRD, TEM, SAED, FTIR, SEM assess crystallinity, surface morphology, functional groups. were obtained by MAPLE. In vitro biocompatibility tests showed that HAp@CPT HAp@CPT/QUE supported osteoblast viability adhesion exhibiting selective cytotoxic effects on osteosarcoma cells. Griess assay indicated nitric oxide (NO) levels remained unchanged in hFOB osteoblasts, confirming neither coating induced inflammatory responses healthy contrast, MG63 cells exhibited significantly elevated NO (p < 0.05) response HAp@CPT/QUE, suggesting increased oxidative stress. MTT results 12% 28% reduction cell respectively. Phase-contrast microscopy further confirmed strong reduced attachment, surfaces. findings highlight the functionality hydroxyapatite–carboplatin–quercetin coatings, promoting exerting anticancer effects. Their bone-regenerative properties make them material endoprostheses oncological applications.
Язык: Английский
Процитировано
0
Small Science, Год журнала: 2024, Номер 4(8)
Опубликована: Май 10, 2024
Nanoscale metal-organic frameworks (NMOFs) exhibit unique properties for drug delivery, including ultrahigh storage capabilities, biocompatibility, biodegradability, and sustained release of encapsulated cargo. However, due to their localized electronic states, MOFs are nonresponsive external stimuli such as light or magnetic fields. This study investigates the integration light-responsive nanoantennas into NMOFs enhance application smart delivery nanosystems. By integrating gold bipyramid within ZIF-8 NU-1000 NMOFs, core@shell nanosystems created with photothermal capabilities. Utilizing cresyl violet a model drug, loading dynamics these analyzed, demonstrating controlled under near-infrared (NIR) stimulation. Photothermal studies conducted in living cells reveal potential nanocomposites spatiotemporal targeted, light-activated delivery. Further evaluation nanocomposite loaded chemotherapeutics-doxorubicin, carboplatin, oxaliplatin-in both 2D 3D cell cultures shows nanosystem effectiveness internalization therapeutic NIR activation. The findings demonstrate that incorporation stimuli-responsive elements offers promising approach developing advanced platforms.
Язык: Английский
Процитировано
3
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(17), С. 9337 - 9337
Опубликована: Авг. 28, 2024
The search for new antineoplastic agents is imperative, as cancer remains one of the most preeminent causes death worldwide. Since discovery therapeutic potential cisplatin, study metallodrugs in chemotherapy acquired increasing interest. Starting from cisplatin derivatives, such oxaliplatin and carboplatin, last years, different compounds were explored, employing metal centers iron, ruthenium, gold, palladium. Nonetheless, face several drawbacks, low water solubility, rapid clearance, possible side toxicity. Encapsulation has emerged a promising strategy to overcome these issues, providing both improved biocompatibility protection payload degradation biological environment. In this respect, liposomes, which are spherical vesicles characterized by an aqueous core surrounded lipid bilayers, have proven be ideal candidates due their versatility. fact, they can encapsulate hydrophilic hydrophobic drugs, biocompatible, properties tuned improve selective delivery tumour sites exploiting passive active targeting. review, we report recent findings on liposomal formulations metallodrugs, with focus encapsulation techniques obtained results.
Язык: Английский
Процитировано
3
Rare Metals, Год журнала: 2024, Номер 43(10), С. 5152 - 5163
Опубликована: Авг. 12, 2024
Язык: Английский
Процитировано
1
Journal of Colloid and Interface Science, Год журнала: 2024, Номер 682, С. 31 - 40
Опубликована: Ноя. 23, 2024
Язык: Английский
Процитировано
1
OpenNano, Год журнала: 2024, Номер 21, С. 100225 - 100225
Опубликована: Дек. 11, 2024
Язык: Английский
Процитировано
1