Pharmaceutics,
Год журнала:
2024,
Номер
16(6), С. 765 - 765
Опубликована: Июнь 4, 2024
Nanoliposomes
are
nano-sized
vesicles
that
can
be
used
as
drug
delivery
carriers
with
the
ability
to
encapsulate
both
hydrophobic
and
hydrophilic
compounds.
Moreover,
their
lipid
compositions
facilitate
internalization
by
cells.
However,
interaction
between
nanoliposomes
membrane
barrier
of
human
body
is
not
well-known.
If
cellular
tests
animal
testing
offer
a
solution,
lack
physiological
relevance
ethical
concerns
make
them
unsuitable
properly
mimic
complexity.
Microfluidics,
which
allows
environment
imitated
in
controlled
way,
fulfil
this
role.
existing
models
missing
presence
something
would
basal
membrane,
often
consisting
simple
cell
layer
on
polymer
membrane.
In
study,
we
investigated
diffusion
microfluidic
system
found
optimal
parameters
maximize
diffusion.
Then,
incorporated
custom
made
GelMA
degree
substitution
studied
passage
fluorescently
labeled
through
barrier.
Our
results
show
highly
substituted
was
more
porous
than
lower
GelMA.
Overall,
our
work
lays
foundation
for
incorporation
hydrogel
mimicking
platform.
Medicinal Research Reviews,
Год журнала:
2023,
Номер
43(6), С. 2115 - 2176
Опубликована: Май 11, 2023
Abstract
Breast
cancer
is
the
most
malignant
tumor
in
women,
and
there
no
absolute
cure
for
it.
Although
treatment
modalities
including
surgery,
chemotherapy,
radiotherapy
are
utilized
breast
cancer,
it
still
a
life‐threatening
disease
humans.
Nanomedicine
has
provided
new
opportunity
treatment,
which
focus
of
current
study.
The
nanocarriers
deliver
chemotherapeutic
agents
natural
products,
both
increase
cytotoxicity
against
cells
prevent
development
drug
resistance.
efficacy
gene
therapy
boosted
by
nanoparticles
delivery
CRISPR/Cas9,
Noncoding
RNAs,
RNAi,
promoting
their
potential
expression
regulation.
codelivery
can
exert
synergistic
impact
on
tumors
enhance
cellular
uptake
via
endocytosis.
Nanostructures
able
to
induce
photothermal
photodynamic
ablation
cell
death
induction.
provide
microenvironment
remodeling
repolarization
macrophages
antitumor
immunity.
stimuli‐responsive
nanocarriers,
pH‐,
redox‐,
light‐sensitive,
mediate
targeted
suppression
tumors.
Besides,
diagnosis
detect
biomarkers.
Various
kinds
have
been
employed
therapy,
carbon‐,
lipid‐,
polymeric‐
metal‐based
nanostructures,
different
terms
biocompatibility
efficiency.
Cellular and Molecular Life Sciences,
Год журнала:
2024,
Номер
81(1)
Опубликована: Май 11, 2024
The
non-coding
RNAs
comprise
a
large
part
of
human
genome
lack
capacity
in
encoding
functional
proteins.
Among
various
members
RNAs,
the
circular
(circRNAs)
have
been
importance
pathogenesis
diseases,
especially
cancer.
circRNAs
unique
closed
loop
structure
and
due
to
their
stability,
they
are
potential
diagnostic
prognostic
factors
increasing
evidences
highlighted
role
modulation
proliferation
metastasis
cancer
cells.
On
other
hand,
has
responsible
for
up
90%
cancer-related
deaths
patients,
requiring
more
investigation
regarding
underlying
mechanisms
modulating
this
mechanism.
EMT
enhances
invasion
tumor
cells,
can
trigger
resistance
therapy.
cells
demonstrate
dynamic
changes
during
including
transformation
from
epithelial
phenotype
into
mesenchymal
increase
N-cadherin
vimentin
levels.
process
is
reversible
its
reprogramming
disrupt
progression
aim
current
review
understanding
interaction
cancers
such
beyond
regulation
affect
response
chemotherapy
radiotherapy.
onco-suppressor
inhibit
EMT,
while
tumor-promoting
mediate
acceleration
carcinogenesis.
Moreover,
EMT-inducing
transcription
be
controlled
by
different
tumors.
ACS Applied Bio Materials,
Год журнала:
2023,
Номер
6(6), С. 2266 - 2276
Опубликована: Июнь 5, 2023
Fruits
are
safe,
toxin-free,
and
biomolecule-rich
raw
materials
that
may
be
utilized
to
decrease
metal
ions
stabilize
nanoparticles.
Here,
we
demonstrate
the
green
synthesis
of
magnetite
nanoparticles
which
were
first
capped
with
a
layer
silica,
followed
by
decoration
silver
nanoparticles,
termed
Ag@SiO2@Fe3O4,
using
lemon
fruit
extract
as
reducing
agent
in
size
range
∼90
nm.
The
effect
stabilizer
on
characteristics
was
examined
via
different
spectroscopy
techniques,
elemental
composition
multilayer-coated
structures
verified.
saturation
magnetization
bare
Fe3O4
at
room
temperature
recorded
78.5
emu/g,
whereas
it
decreased
56.4
43.8
emu/g
for
silica
coating
subsequent
All
displayed
superparamagnetic
behavior
almost
zero
coercivity.
While
further
processes,
specific
surface
area
increased
from
67
180
m2
g–1
after
addition
reached
98
g–1,
can
explained
organization
an
island-like
model.
Zeta
potential
values
also
−18
−34
mV
coating,
indicating
enhanced
stabilization
silver.
antibacterial
tests
against
Escherichia
coli
(E.
coli)
Staphylococcus
aureus
(S.
aureus)
revealed
SiO2@Fe3O4
did
not
show
sufficient
effect,
while
even
low
concentrations
(≤
200
μg/mL),
high
activity
due
existence
atoms
Furthermore,
vitro
cytotoxicity
assay
Ag@SiO2@Fe3O4
toxic
HSF-1184
cells
μg/mL
concentration.
Antibacterial
during
consecutive
magnetic
separation
recycling
steps
investigated,
offered
more
than
10
cycles
recycling,
making
them
potentially
useful
biomedical
fields.
