International Journal of Biological Macromolecules, Год журнала: 2024, Номер 293, С. 139275 - 139275
Опубликована: Дек. 28, 2024
Язык: Английский
Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106698 - 106698
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
1
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 267, С. 131401 - 131401
Опубликована: Апрель 4, 2024
Язык: Английский
Процитировано
4
Molecular Pharmaceutics, Год журнала: 2025, Номер unknown
Опубликована: Март 9, 2025
To enhance the therapeutic efficacy and safety of triple-negative breast cancer (TNBC) treatment, we developed a hypoxia-responsive drug delivery system utilizing digoxin (DIG) to inhibit HIF-1α sensitize TNBC doxorubicin (DOX). DIG, cardiac steroid with well-characterized pharmacological mechanism, was encapsulated in micelles composed methoxy-polyethylene glycol (mPEG) poly(lactic acid) (PLA) copolymers, incorporating an azobenzene (AZO) trigger for hypoxia-sensitive release. The loading ratio DOX DIG optimized based on DIG's minimum effective dose. In vitro vivo studies demonstrated that efficiently delivered their payload hypoxic tumor regions, enabling rapid DIG-mediated inhibition enhanced sensitivity DOX, leading significant suppression both primary growth pulmonary metastasis. This study presents promising clinically feasible strategy other hypoxia-driven malignancies.
Язык: Английский
Процитировано
0
Materials Chemistry and Physics, Год журнала: 2025, Номер unknown, С. 130699 - 130699
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Molecules, Год журнала: 2024, Номер 29(15), С. 3520 - 3520
Опубликована: Июль 26, 2024
Active ingredients from Traditional Chinese Medicines (TCMs) have been a cornerstone of healthcare for millennia, offering rich source bioactive compounds with therapeutic potential. However, the clinical application TCMs is often limited by challenges such as poor solubility, low bioavailability, and variable pharmacokinetics. To address these issues, development advanced polymer nanocarriers has emerged promising strategy delivery TCMs. This review focuses on introduction common active recent advancements in design enhancing efficacy safety We begin discussing unique properties inherent associated their delivery. then delve into types polymeric nanocarriers, including micelles, vesicles, hydrogels, drug conjugates, highlighting The main body presents comprehensive analysis state-of-the-art nanocarrier systems introduces impact stability, bioavailability TCM components. On basis this, we provide an outlook future directions underscores transformative potential revolutionizing delivery, pathway to harness full while ensuring modern medical context.
Язык: Английский
Процитировано
2
Polymers, Год журнала: 2024, Номер 16(17), С. 2503 - 2503
Опубликована: Сен. 3, 2024
Many therapies require the transport of therapeutic compounds or substances encapsulated in carriers that reduce or, if possible, eliminate their direct contact with healthy tissue and components immune system, which may react to them as something foreign dangerous patient’s body. To date, inorganic nanoparticles, solid lipids, micelles micellar aggregates, liposomes, polymeric micelles, other polymer assemblies were tested drug carriers. Specifically, using polymers creates a variety options prepare nanocarriers tailored chosen needs. Among polymers, aliphatic polyesters are particularly important group. The review discusses controlled synthesis poly(β-butyrolactone)s, polylactides, polyglycolide, poly(ε-caprolactone), copolymers containing polymacrolactone units double bonds suitable for preparation functionalized nanoparticles. Discussed syntheses molar masses ranging from few thousand 106 and, case chiral centers chains, microstructure. presents also collection methods useful drug-loaded nanocarriers: classical, developed mastered more recently (e.g., nanoprecipitation), forgotten but still great potential (by nanoparticles process comprising monomer drug). article describes in-vitro model in-vivo studies brain-targeted drugs based on polyester-containing brief update clinical polyester nanocarrier formulation approved application clinics South Korea treatment breast, lung, ovarian cancers.
Язык: Английский
Процитировано
2
Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 101, С. 106158 - 106158
Опубликована: Сен. 6, 2024
Язык: Английский
Процитировано
2
Regenerative Engineering and Translational Medicine, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 25, 2024
Язык: Английский
Процитировано
2
Archiv der Pharmazie, Год журнала: 2024, Номер unknown
Опубликована: Дек. 9, 2024
Polysaccharides, the most abundant biopolymers in nature, have attracted attention of researchers and clinicians due to its practicality biomedical pharmaceutical sciences. These biomaterials high bioavailability play structural functional roles living organisms. Polysaccharides are classified into several groups based on their origin, including plant polysaccharides marine (like chitosan, hyaluronic acid, dextran, alginates, etc.) with specific applications. possess unique physicochemical (such as surface groups, solubility, stability), mechanical strength tensile), antioxidant activity, biocompatibility, biodegradability, renewability, non-immunogenicity) characteristics which made them excellent platforms for a wide variety Ease extraction different preparation approaches mentioned other potential properties that further improved They drug/bioactive encapsulation capacity sustained/controlled release manner vivo microenvironments. The anti-inflammatory immunomodulation, stimuli-responsive release, passive active delivery considered features these indicated practical applications sciences, biosensors, tissue engineering, implantation, wound healing, vascular grafting, vaccines. This review highlights advances polysaccharide-based materials
Язык: Английский
Процитировано
2
Burns & Trauma, Год журнала: 2024, Номер 12
Опубликована: Янв. 1, 2024
Considering the increasing abundance of antibiotic-resistant bacteria, novel antimicrobial approaches need to be investigated. Photothermal therapy (PTT), an innovative noninvasive therapeutic technique, has demonstrated significant potential in addressing drug-resistant bacteria and bacterial biofilms. However, when used isolation, PTT requires higher-temperature conditions effectively eradicate thereby potentially harming healthy tissues inducing new inflammation. This study aims present a comprehensive review nanomaterials with intrinsic properties, materials relying on photothermal action, using drug delivery along their applications antimicrobials. Additionally, synergistic mechanisms these are elucidated. The provides reference for developing multifunctional nanoplatforms treating bacterially infected wounds.
Язык: Английский
Процитировано
2