Recent advancements in the targeted delivery of Gemcitabine: Harnessing nanomedicine for enhanced cancer therapy

OpenNano, Год журнала: 2023, Номер 13, С. 100177 - 100177

Опубликована: Июль 24, 2023

Gemcitabine (GEM) is a chemotherapeutic drug widely used for treating pancreatic cancer and other cancers. Despite its efficacy, GEM associated with adverse side effects tumor resistance, hampering therapeutic outcomes. To address these challenges, innovative strategies have emerged to enhance delivery. This comprehensive review explores various distribution systems, including polymer-based platforms, liposomes, inorganic nanoparticles, highlighting their unique characteristics improving efficacy in treatment. Additionally, we discuss the promising approach of codelivery genes present several methods augmenting GEM's properties. Our findings shed light on novel insights provide recommendations overcoming limitations GEM, guiding researchers clinicians toward more effective therapies.

Язык: Английский

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Self-enhanced PTX@HSA-HA loaded functionalized injectable hydrogel for effective local chemo-photothermal therapy in breast cancer

Carbohydrate Polymers, Год журнала: 2024, Номер 345, С. 122569 - 122569

Опубликована: Авг. 2, 2024

Язык: Английский

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Intrinsically Disordered Synthetic Polymers in Biomedical Applications

Polymers, Год журнала: 2023, Номер 15(10), С. 2406 - 2406

Опубликована: Май 22, 2023

In biology and medicine, intrinsically disordered synthetic polymers bio-mimicking proteins, which lack stable three-dimensional structures, possess high structural/conformational flexibility. They are prone to self-organization can be extremely useful in various biomedical applications. Among such applications, have potential usage drug delivery, organ transplantation, artificial design, immune compatibility. The designing of new syntheses characterization mechanisms is currently required provide the lacking for applications bio-mimicked using proteins. Here, we present our strategies based on

Язык: Английский

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Effect of strong and weak polyelectrolytes on the properties of cationic surfactant with triallyl ammonium head group: self-assembly and biological assessment

Materials Chemistry and Physics, Год журнала: 2024, Номер 320, С. 129441 - 129441

Опубликована: Май 9, 2024

Язык: Английский

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A carboxymethyl-resistant starch/polyacrylic acid semi-IPN hydrogel with excellent adhesive and antibacterial properties for peri-implantitis prevention

Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 242, С. 114082 - 114082

Опубликована: Июль 15, 2024

Язык: Английский

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