Facet-dependent magnetic properties of magnetite nanoparticles coated with dodecyl amine and their biological effect in hepatocarcinoma cell line

Journal of Materials Science, Год журнала: 2024, Номер 59(3), С. 991 - 1009

Опубликована: Янв. 1, 2024

Abstract Herein was conducted a compelling structural analysis of magnetite nanoparticles (NPs) coated with dodecyl amine (DDA), compared uncoated magnetite, both previously synthesized by an accelerated one-pot synthesis, starting from single iron precursor. XRD/TEM results for the obtained nanomaterial Fe 3 O 4 @DDA showed predominance 3+ cations on most stable atomic plane (111). Using Molecular Dynamics calculations, observed dispositions as inputs, it established that NPs' surface and DDA might interact short-distance coordination, ligand cations, or long-distance adsorption via H-bonding. The simulations align TEM images, revealing amorphous contour corresponding to organic coating arranged bilayer. TGA corroborated dual mass loss profile relating bilayer at 116 °C 350 °C. NPs’ magnetic properties (saturation magnetization ( M s ) coercivity field H c )) were preserved. exhibited reduction emu/g in increment 12 Oe , NPs, attributable inhomogeneity consequent anisotropy rise. triggered concentration-dependent cytotoxic effects human hepatocarcinoma cell line HepG2. At 50 µg/mL after incubation 48 h, viability 63% < whereas 72 h only 30% cells viable. 300 µg/mL, less than 10% HepG2 remained viable 24 incubation. In case NPs assessed same line, high 80% during Trypan blue assay suggests membrane integrity damage primary mechanism death. Even though vitro herein presented are preliminary, they represent first report effect nitrogenous surfactant. Graphical abstract

Язык: Английский

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A review on toxicity mechanism and risk factors of nanoparticles in respiratory tract

Toxicology, Год журнала: 2024, Номер 504, С. 153781 - 153781

Опубликована: Март 15, 2024

Язык: Английский

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Evaluating of novel Mn–Mg–Co ferrite nanoparticles for biomedical applications: From synthesis to biological activities

Ceramics International, Год журнала: 2023, Номер 49(24), С. 40421 - 40434

Опубликована: Окт. 4, 2023

Язык: Английский

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Targeted Nanotheranostics: Integration of Preclinical MRI and CT in the Molecular Imaging and Therapy of Advanced Diseases

Nanotheranostics, Год журнала: 2024, Номер 8(3), С. 401 - 426

Опубликована: Янв. 1, 2024

The integration of preclinical magnetic resonance imaging (MRI) and computed tomography (CT) methods has significantly enhanced the area therapy targeted nanomedicine.Nanotheranostics, which make use nanoparticles, are a significant advancement in MRI CT imaging.In addition to giving high-resolution anatomical features functional information simultaneously, these multifunctional agents improve contrast when used.In enabling early disease detection, precise localization, personalised monitoring, they also enable detection.Fusion enables vivo tracking drug-loaded nanoparticles.MRI, provides real-time monitoring nanoparticle distribution, accumulation, release at cellular tissue levels, can be used assess efficacy drug delivery systems.The localization nanoparticles within body is achievable through imaging.This technique enhances capabilities by providing information.CT allows for quantitative measurements concentration, essential evaluating pharmacokinetics biodistribution nanomedicine.In this article, we emphasize into molecular advanced diseases.

Язык: Английский

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Magnetic Nanoparticles as Mediators for Magnetic Hyperthermia Therapy Applications: A Status Review

Applied Sciences, Год журнала: 2023, Номер 13(17), С. 9548 - 9548

Опубликована: Авг. 23, 2023

This concise review delves into the realm of superparamagnetic nanoparticles, specifically focusing on Fe2O3, Mg1+xFe2−2xTixO4, Ni1−xCux, and CrxNi1−x, along with their synthesis methods applications in magnetic hyperthermia. Remarkable advancements have been made controlling size shape these achieved through various techniques such as coprecipitation, mechanical milling, microemulsion, sol–gel synthesis. Through this review, our objective is to present outcomes diverse methods, surface treatment properties, Curie temperature, elucidate impact heating efficiency when subjected high-frequency fields.

Язык: Английский

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The role of magnetic nanoparticles in cancer management

Nano-Structures & Nano-Objects, Год журнала: 2023, Номер 36, С. 101053 - 101053

Опубликована: Окт. 1, 2023

According to WHO, cancer is a deadly disease and the second cause of death globally. Conventional treatment methods, such as chemotherapy, surgery, radiography, etc., have been bedeviled with numerous adverse effects. Hence, efforts made find suitable technique little or no side effects for diagnoses treatment. In searching an alternative medicine, using magnetic nanoparticles (MNPs) in diagnosis has recently gained lot interest among researchers. This due their excellent properties, biocompatibility, non-toxic nature, stability, mention few. this review, we extensively discussed various methods synthesis MNPs, comparing merits demerits. The functionalization MNPs reason it were detailedly described. Also covered review application diagnosis, including MRI MPI. explained strategies, hyperthermia, magnetic-guided drug delivery, theranostic platforms. Furthermore, use modeling simulation predicting optimizing performance ensure effectiveness was discussed. Finally, looked at toxicity-related concerns future perspective on applications these MNPs.

Язык: Английский

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Biosynthesis Optimization of Antibacterial-Magnetic Iron Oxide Nanoparticles from Bacillus megaterium

Biological Trace Element Research, Год журнала: 2024, Номер unknown

Опубликована: Апрель 12, 2024

Язык: Английский

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Applications of peptides in nanosystems for diagnosing and managing bacterial sepsis

Journal of Biomedical Science, Год журнала: 2024, Номер 31(1)

Опубликована: Апрель 19, 2024

Abstract Sepsis represents a critical medical condition stemming from an imbalanced host immune response to infections, which is linked significant burden of disease. Despite substantial efforts in laboratory and clinical research, sepsis remains prominent contributor mortality worldwide. Nanotechnology presents innovative opportunities for the advancement diagnosis treatment. Due their unique properties, including diversity, ease synthesis, biocompatibility, high specificity, excellent pharmacological efficacy, peptides hold great potential as part nanotechnology approaches against sepsis. Herein, we present comprehensive up-to-date review applications nanosystems combating sepsis, with expedite enhance management outcomes. Firstly, pathophysiology, antisepsis drug targets, current modalities limitations, advance have been adequately addressed. The organized into diagnostic or managing applications, last one being further sub-organized nano-delivered bioactive antimicrobial anti-inflammatory activity, targeting moieties on surface nanocarriers agents. studies grouped thematically discussed, emphasizing constructed nanosystem, physicochemical peptide-imparted enhancement therapeutic efficacy. strengths, research gaps each section elaborated. Finally, challenges future paths use deliberately spotlighted. This reaffirms peptides' promising biomaterials within strategies aimed at improving management. Graphical

Язык: Английский

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Advanced manufacturing of nanoparticle formulations of drugs and biologics using microfluidics

The Analyst, Год журнала: 2023, Номер 149(3), С. 614 - 637

Опубликована: Ноя. 28, 2023

Numerous innovative nanoparticle formulations of drugs and biologics, named nano-formulations, have been developed in the last two decades. However, methods for their scaled-up production are still lagging, as amount needed large animal tests clinical trials is typically orders magnitude larger. This manufacturing challenge poses a critical barrier to successfully translating various nano-formulations. review focuses on how microfluidics technology has become powerful tool overcome this by synthesizing nano-formulations with improved particle properties product purity quantities. microfluidic-based enabled microfluidic mixing, which capable precise continuous control synthesis We further discuss specific applications hydrodynamic flow focusing, staggered herringbone micromixer, T-junction mixer, micro-droplet generator, glass capillary types polymeric, lipid, inorganic, nanocrystals. Various separation purification enhance reviewed, including acoustofluidics, hydrodynamics, dielectrophoresis. challenges being used broader research industrial communities. also provide future outlooks its enormous potential decentralized approach

Язык: Английский

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Influence of silane coating and graphene oxide integration on the magnetothermal Behaviors of La1-xSrxMnO3 nanoparticles

Journal of Magnetism and Magnetic Materials, Год журнала: 2025, Номер unknown, С. 172808 - 172808

Опубликована: Янв. 1, 2025

Язык: Английский

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