Facet-dependent magnetic properties of magnetite nanoparticles coated with dodecyl amine and their biological effect in hepatocarcinoma cell line

Journal of Materials Science, Journal Year: 2024, Volume and Issue: 59(3), P. 991 - 1009

Published: Jan. 1, 2024

Abstract Herein was conducted a compelling structural analysis of magnetite nanoparticles (NPs) coated with dodecyl amine (DDA), compared uncoated magnetite, both previously synthesized by an accelerated one-pot synthesis, starting from single iron precursor. XRD/TEM results for the obtained nanomaterial Fe 3 O 4 @DDA showed predominance 3+ cations on most stable atomic plane (111). Using Molecular Dynamics calculations, observed dispositions as inputs, it established that NPs' surface and DDA might interact short-distance coordination, ligand cations, or long-distance adsorption via H-bonding. The simulations align TEM images, revealing amorphous contour corresponding to organic coating arranged bilayer. TGA corroborated dual mass loss profile relating bilayer at 116 °C 350 °C. NPs’ magnetic properties (saturation magnetization ( M s ) coercivity field H c )) were preserved. exhibited reduction emu/g in increment 12 Oe , NPs, attributable inhomogeneity consequent anisotropy rise. triggered concentration-dependent cytotoxic effects human hepatocarcinoma cell line HepG2. At 50 µg/mL after incubation 48 h, viability 63% < whereas 72 h only 30% cells viable. 300 µg/mL, less than 10% HepG2 remained viable 24 incubation. In case NPs assessed same line, high 80% during Trypan blue assay suggests membrane integrity damage primary mechanism death. Even though vitro herein presented are preliminary, they represent first report effect nitrogenous surfactant. Graphical abstract

Language: Английский

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A review on toxicity mechanism and risk factors of nanoparticles in respiratory tract

Toxicology, Journal Year: 2024, Volume and Issue: 504, P. 153781 - 153781

Published: March 15, 2024

Language: Английский

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Evaluating of novel Mn–Mg–Co ferrite nanoparticles for biomedical applications: From synthesis to biological activities

Ceramics International, Journal Year: 2023, Volume and Issue: 49(24), P. 40421 - 40434

Published: Oct. 4, 2023

Language: Английский

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Targeted Nanotheranostics: Integration of Preclinical MRI and CT in the Molecular Imaging and Therapy of Advanced Diseases

Nanotheranostics, Journal Year: 2024, Volume and Issue: 8(3), P. 401 - 426

Published: Jan. 1, 2024

The integration of preclinical magnetic resonance imaging (MRI) and computed tomography (CT) methods has significantly enhanced the area therapy targeted nanomedicine.Nanotheranostics, which make use nanoparticles, are a significant advancement in MRI CT imaging.In addition to giving high-resolution anatomical features functional information simultaneously, these multifunctional agents improve contrast when used.In enabling early disease detection, precise localization, personalised monitoring, they also enable detection.Fusion enables vivo tracking drug-loaded nanoparticles.MRI, provides real-time monitoring nanoparticle distribution, accumulation, release at cellular tissue levels, can be used assess efficacy drug delivery systems.The localization nanoparticles within body is achievable through imaging.This technique enhances capabilities by providing information.CT allows for quantitative measurements concentration, essential evaluating pharmacokinetics biodistribution nanomedicine.In this article, we emphasize into molecular advanced diseases.

Language: Английский

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Magnetic Nanoparticles as Mediators for Magnetic Hyperthermia Therapy Applications: A Status Review

Applied Sciences, Journal Year: 2023, Volume and Issue: 13(17), P. 9548 - 9548

Published: Aug. 23, 2023

This concise review delves into the realm of superparamagnetic nanoparticles, specifically focusing on Fe2O3, Mg1+xFe2−2xTixO4, Ni1−xCux, and CrxNi1−x, along with their synthesis methods applications in magnetic hyperthermia. Remarkable advancements have been made controlling size shape these achieved through various techniques such as coprecipitation, mechanical milling, microemulsion, sol–gel synthesis. Through this review, our objective is to present outcomes diverse methods, surface treatment properties, Curie temperature, elucidate impact heating efficiency when subjected high-frequency fields.

Language: Английский

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The role of magnetic nanoparticles in cancer management

Nano-Structures & Nano-Objects, Journal Year: 2023, Volume and Issue: 36, P. 101053 - 101053

Published: Oct. 1, 2023

According to WHO, cancer is a deadly disease and the second cause of death globally. Conventional treatment methods, such as chemotherapy, surgery, radiography, etc., have been bedeviled with numerous adverse effects. Hence, efforts made find suitable technique little or no side effects for diagnoses treatment. In searching an alternative medicine, using magnetic nanoparticles (MNPs) in diagnosis has recently gained lot interest among researchers. This due their excellent properties, biocompatibility, non-toxic nature, stability, mention few. this review, we extensively discussed various methods synthesis MNPs, comparing merits demerits. The functionalization MNPs reason it were detailedly described. Also covered review application diagnosis, including MRI MPI. explained strategies, hyperthermia, magnetic-guided drug delivery, theranostic platforms. Furthermore, use modeling simulation predicting optimizing performance ensure effectiveness was discussed. Finally, looked at toxicity-related concerns future perspective on applications these MNPs.

Language: Английский

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Biosynthesis Optimization of Antibacterial-Magnetic Iron Oxide Nanoparticles from Bacillus megaterium

Biological Trace Element Research, Journal Year: 2024, Volume and Issue: unknown

Published: April 12, 2024

Language: Английский

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Applications of peptides in nanosystems for diagnosing and managing bacterial sepsis

Journal of Biomedical Science, Journal Year: 2024, Volume and Issue: 31(1)

Published: April 19, 2024

Abstract Sepsis represents a critical medical condition stemming from an imbalanced host immune response to infections, which is linked significant burden of disease. Despite substantial efforts in laboratory and clinical research, sepsis remains prominent contributor mortality worldwide. Nanotechnology presents innovative opportunities for the advancement diagnosis treatment. Due their unique properties, including diversity, ease synthesis, biocompatibility, high specificity, excellent pharmacological efficacy, peptides hold great potential as part nanotechnology approaches against sepsis. Herein, we present comprehensive up-to-date review applications nanosystems combating sepsis, with expedite enhance management outcomes. Firstly, pathophysiology, antisepsis drug targets, current modalities limitations, advance have been adequately addressed. The organized into diagnostic or managing applications, last one being further sub-organized nano-delivered bioactive antimicrobial anti-inflammatory activity, targeting moieties on surface nanocarriers agents. studies grouped thematically discussed, emphasizing constructed nanosystem, physicochemical peptide-imparted enhancement therapeutic efficacy. strengths, research gaps each section elaborated. Finally, challenges future paths use deliberately spotlighted. This reaffirms peptides' promising biomaterials within strategies aimed at improving management. Graphical

Language: Английский

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Preparation, characterization and in vitro applications of morin hydrate loaded HPAC@MNPs nanocomposite

Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi, Journal Year: 2025, Volume and Issue: 15(1), P. 217 - 227

Published: Feb. 19, 2025

Cancer is a prevalent and fatal illness that claims the lives of millions people globally every year, impacting individuals across all age groups ethnicities. Because drugs are used to treat cancer affect both malignant healthy cells without discrimination, they responsible for systemic toxicity in addition creating major adverse effects Recently, drug delivery systems specifically target specific sites have been developed minimize caused by drugs. Morin (MRN) flavonol-based has subject substantial research conducted investigate its antiangiogenic, anti-inflammatory, anticancer, antibacterial activities. This study included synthesis product with magnetic properties applying layer nanoparticles onto biocompatible activated carbon derived from hawthorn plant. Characterization HPAC@MNPs synthesized nanoparticle (MNPs) (AC) obtained plant (HP) was confirmed Fourier Transform Infrared (FTIR), Scanning Electron Microscope (SEM), dynamic light scattering (DLS) Zeta Potential. DLS analysis calculated average particle size HPAC@MNPs-MRN be about 105 nm 142 nm, respectively. The drug-loaded nanocomposite evaluated cytotoxic on MCF-7 (breast), U373 (Glioblastoma) cell lines, Human Umbilical Vein Endothelial Cells (HUVEC) line. MRN loading release characteristics were analyzed. results indicated enclosed medication exhibited prolonged spreading time during release. In summary, use carriers may great potential effectively deliver sites.

Language: Английский

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Influence of silane coating and graphene oxide integration on the magnetothermal Behaviors of La1-xSrxMnO3 nanoparticles

Journal of Magnetism and Magnetic Materials, Journal Year: 2025, Volume and Issue: unknown, P. 172808 - 172808

Published: Jan. 1, 2025

Language: Английский

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