Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 30 - 47
Опубликована: Янв. 1, 2024
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(17), С. 13157 - 13157
Опубликована: Авг. 24, 2023
Bone tissue engineering has attracted great interest in the last few years, as frequency of tissue-damaging or degenerative diseases increased exponentially. To obtain an ideal treatment solution, researchers have focused on development optimum biomaterials to be applied for enhancement bioactivity and regeneration process, which are necessary support proper healing process osseous tissues. In this regard, hydroxyapatite (HA) been most widely used material biomedical field due its biocompatibility similarity with native apatite from human bone. However, HA still presents some deficiencies related mechanical properties, essential load-bearing applications. Bioactivity is another vital property further improve antibacterial activity. These drawbacks can solved by doping trace elements, adapting properties material, and, finally, sustaining bone without occurrence implant failure. Considering these aspects, review, we presented general information about synthesis methods, applications, necessity addition ions into structure. Also, their influence HA, well latest applications doped materials field.
Язык: Английский
Процитировано
50
Advances in Colloid and Interface Science, Год журнала: 2023, Номер 322, С. 103035 - 103035
Опубликована: Ноя. 3, 2023
Surface-functionalized nanostructures are at the forefront of biotechnology, providing new opportunities for biosensors, drug delivery, therapy, and bioimaging applications. The modification significantly impacts performance success various applications by enabling selective precise targeting. This review elucidates widely practiced surface strategies, including click chemistry, cross-coupling, silanization, aldehyde linkers, active ester maleimide epoxy other protein DNA-based methodologies. We also delve into application-focused landscape nano-bio interface, emphasizing four key domains: therapeutics, biosensing, environmental monitoring, point-of-care technologies, highlighting prominent studies. insights presented herein pave way further innovations intersection nanotechnology a useful handbook beginners professionals. draws on sources, latest research articles (2018-2023), to provide comprehensive overview field.
Язык: Английский
Процитировано
49
Current Issues in Molecular Biology, Год журнала: 2024, Номер 46(1), С. 585 - 611
Опубликована: Янв. 5, 2024
Numerous surgeries are carried out to replace tissues that have been harmed by an illness or accident. Due various surgical interventions and the requirement of bone substitutes, emerging field tissue engineering attempts repair damaged with help scaffolds. These scaffolds act as template for regeneration controlling development new cells. For creation functional organs, there three elements play very crucial role: cells, signals achievement these aims, types natural polymers, like chitosan, chitin, cellulose, albumin silk fibroin, used preparation Scaffolds produced from polymers many advantages: they less immunogenic well being biodegradable, biocompatible, non-toxic cost effective. The hierarchal structure bone, microscale nanoscale, is mostly made up organic inorganic components nanohydroxyapatite collagen components. This review paper summarizes knowledge updates information about use scaffolds, their application in recent research trends area (BTE). article extensively explores related analyze advancement nanotechnology treatment bone-related diseases repair.
Язык: Английский
Процитировано
27
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 278, С. 134615 - 134615
Опубликована: Авг. 10, 2024
Язык: Английский
Процитировано
19
Discover Nano, Год журнала: 2024, Номер 19(1)
Опубликована: Май 9, 2024
Biomedical nanocomposites, which are an upcoming breed of mischievous materials, have ushered in a new dimension the healthcare sector. Incorporating these materials tends to boost features this component already possesses and give might things components could not withstand alone. The biopolymer, carries nanoparticles, can simultaneously improve composite's stiffness biological characteristics, vice versa. This increases options composite number times it be used. bio-nanocomposites nanoparticles enable ecocompatibility medicine their biodegradability, they, way, ecological sustainability. outcome is improved properties its associated positive impact on environment. They broad applications antimicrobial agents, drug carriers, tissue regeneration, wound care, dentistry, bioimaging, bone filler, among others. dissertation elements emphasizes production techniques, diverse medicine, match-up issues, future-boasting prospects field. Through utilization such scientists develop more suitable for environment healthy biomedical solutions, world way improves as well.
Язык: Английский
Процитировано
18
Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 99, С. 105958 - 105958
Опубликована: Июль 9, 2024
Язык: Английский
Процитировано
18
Alexandria Engineering Journal, Год журнала: 2023, Номер 87, С. 277 - 299
Опубликована: Дек. 28, 2023
Conjugated polymers such as polypyrrole, polyaniline, and polythiophene have developed capable candidates for scaffold fabrication due to their electrical conductivity, tunable surface properties, ability deliver bioactive molecules. When blended with other biomaterials nanoparticles enables the formation of composites that leverage advantages both components. The main focus areas review include use conjugated polymer-based (CPCs) tissue engineering e.g., neural, cardiac, bone, skin. Within each section, specific examples are provided polymer-biomolecule composite systems been explored along a discussion composition, fabrication, performance supporting cell growth regeneration. Finally, current challenges future perspectives discussed in applying CPCs toward clinically relevant tissues organs. Overall, this comprehensive covers fundamental design considerations developing polymer scaffolds emerging applications engineering.
Язык: Английский
Процитировано
29
Journal of Functional Biomaterials, Год журнала: 2024, Номер 15(9), С. 241 - 241
Опубликована: Авг. 23, 2024
The rising demand for effective bone regeneration has underscored the limitations of traditional methods like autografts and allografts, including donor site morbidity insufficient biological signaling. This review examines nanoparticles (NPs) in tissue engineering (TE) to address these challenges, evaluating polymers, metals, ceramics, composites their potential enhance osteogenesis angiogenesis by mimicking extracellular matrix (ECM) nanostructure. involved synthesizing characterizing nanoparticle-based scaffoldsand integrating hydroxyapatite (HAp) with polymers mechanical properties osteogenic potential. results showed that NPs significantly promote cell growth, differentiation, formation, carbon-based graphene carbon nanotubes showing promise. offer versatile, biocompatible, customizable scaffolds drug delivery support repair. Despite promising results, challenges cytotoxicity, biodistribution, immune responses remain. Addressing issues through surface modifications biocompatible molecules can improve biocompatibility efficacy nanomaterials. Future research should focus on long-term vivo studies assess safety NP-based explore synergistic effects other bioactive or growth factors. underscores transformative advancing BTE calls further optimize technologies clinical applications.
Язык: Английский
Процитировано
14
Chemical Engineering Journal, Год журнала: 2024, Номер 494, С. 152703 - 152703
Опубликована: Июнь 5, 2024
Язык: Английский
Процитировано
12
Materials Chemistry and Physics, Год журнала: 2024, Номер 320, С. 129410 - 129410
Опубликована: Май 2, 2024
Язык: Английский
Процитировано
10