Heliyon,
Год журнала:
2024,
Номер
10(16), С. e36152 - e36152
Опубликована: Авг. 1, 2024
The
biomedical
application
of
biodegradable
polymers
for
addressing
bone-related
diseases
has
garnered
considerable
attention
in
recent
years.
Advances
material
technology
have
expanded
the
repertoire
materials
suitable
orthopedic
implants,
with
nanomaterials
playing
a
pivotal
role
replicating
crucial
surface
properties
akin
to
natural
tissues.
This
comprehensive
review
explores
evaluation
bioactive
glass
ceramics,
shedding
light
on
their
and
applications.
synthesis
composites
through
composite
manufacturing
emerged
as
strategy
enhance
biocompatibility
biomechanical
characteristics.
They
are
challenges
associated
conventional
implants
nanomaterials,
whether
form
functional
nano
coatings
or
nanostructured
surfaces,
present
opportunities
refine
implant
techniques.
Novel
developments
biomaterials,
such
smart
porous
structures,
3D
offer
stimuli-responsive
behavior
achieve
desired
shapes
Bioactive
polymer/inorganic
explored
bone
tissue
engineering
scaffolds,
aiming
promote
formation
regeneration.
As
prospective
direction,
integration
stem
cells
into
scaffolds
hints
at
creation
next-generation
synthetic/living
hybrid
displaying
high
adaptability
biological
settings.
establishes
foundation
nanotechnology-driven
biomaterials
by
elucidating
fundamental
design
factors
performance
response
cell
differentiation,
proliferation,
adhesion.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(17), С. 13157 - 13157
Опубликована: Авг. 24, 2023
Bone
tissue
engineering
has
attracted
great
interest
in
the
last
few
years,
as
frequency
of
tissue-damaging
or
degenerative
diseases
increased
exponentially.
To
obtain
an
ideal
treatment
solution,
researchers
have
focused
on
development
optimum
biomaterials
to
be
applied
for
enhancement
bioactivity
and
regeneration
process,
which
are
necessary
support
proper
healing
process
osseous
tissues.
In
this
regard,
hydroxyapatite
(HA)
been
most
widely
used
material
biomedical
field
due
its
biocompatibility
similarity
with
native
apatite
from
human
bone.
However,
HA
still
presents
some
deficiencies
related
mechanical
properties,
essential
load-bearing
applications.
Bioactivity
is
another
vital
property
further
improve
antibacterial
activity.
These
drawbacks
can
solved
by
doping
trace
elements,
adapting
properties
material,
and,
finally,
sustaining
bone
without
occurrence
implant
failure.
Considering
these
aspects,
review,
we
presented
general
information
about
synthesis
methods,
applications,
necessity
addition
ions
into
structure.
Also,
their
influence
HA,
well
latest
applications
doped
materials
field.
Advances in Colloid and Interface Science,
Год журнала:
2023,
Номер
322, С. 103035 - 103035
Опубликована: Ноя. 3, 2023
Surface-functionalized
nanostructures
are
at
the
forefront
of
biotechnology,
providing
new
opportunities
for
biosensors,
drug
delivery,
therapy,
and
bioimaging
applications.
The
modification
significantly
impacts
performance
success
various
applications
by
enabling
selective
precise
targeting.
This
review
elucidates
widely
practiced
surface
strategies,
including
click
chemistry,
cross-coupling,
silanization,
aldehyde
linkers,
active
ester
maleimide
epoxy
other
protein
DNA-based
methodologies.
We
also
delve
into
application-focused
landscape
nano-bio
interface,
emphasizing
four
key
domains:
therapeutics,
biosensing,
environmental
monitoring,
point-of-care
technologies,
highlighting
prominent
studies.
insights
presented
herein
pave
way
further
innovations
intersection
nanotechnology
a
useful
handbook
beginners
professionals.
draws
on
sources,
latest
research
articles
(2018-2023),
to
provide
comprehensive
overview
field.
Current Issues in Molecular Biology,
Год журнала:
2024,
Номер
46(1), С. 585 - 611
Опубликована: Янв. 5, 2024
Numerous
surgeries
are
carried
out
to
replace
tissues
that
have
been
harmed
by
an
illness
or
accident.
Due
various
surgical
interventions
and
the
requirement
of
bone
substitutes,
emerging
field
tissue
engineering
attempts
repair
damaged
with
help
scaffolds.
These
scaffolds
act
as
template
for
regeneration
controlling
development
new
cells.
For
creation
functional
organs,
there
three
elements
play
very
crucial
role:
cells,
signals
achievement
these
aims,
types
natural
polymers,
like
chitosan,
chitin,
cellulose,
albumin
silk
fibroin,
used
preparation
Scaffolds
produced
from
polymers
many
advantages:
they
less
immunogenic
well
being
biodegradable,
biocompatible,
non-toxic
cost
effective.
The
hierarchal
structure
bone,
microscale
nanoscale,
is
mostly
made
up
organic
inorganic
components
nanohydroxyapatite
collagen
components.
This
review
paper
summarizes
knowledge
updates
information
about
use
scaffolds,
their
application
in
recent
research
trends
area
(BTE).
article
extensively
explores
related
analyze
advancement
nanotechnology
treatment
bone-related
diseases
repair.
Biomedical
nanocomposites,
which
are
an
upcoming
breed
of
mischievous
materials,
have
ushered
in
a
new
dimension
the
healthcare
sector.
Incorporating
these
materials
tends
to
boost
features
this
component
already
possesses
and
give
might
things
components
could
not
withstand
alone.
The
biopolymer,
carries
nanoparticles,
can
simultaneously
improve
composite's
stiffness
biological
characteristics,
vice
versa.
This
increases
options
composite
number
times
it
be
used.
bio-nanocomposites
nanoparticles
enable
ecocompatibility
medicine
their
biodegradability,
they,
way,
ecological
sustainability.
outcome
is
improved
properties
its
associated
positive
impact
on
environment.
They
broad
applications
antimicrobial
agents,
drug
carriers,
tissue
regeneration,
wound
care,
dentistry,
bioimaging,
bone
filler,
among
others.
dissertation
elements
emphasizes
production
techniques,
diverse
medicine,
match-up
issues,
future-boasting
prospects
field.
Through
utilization
such
scientists
develop
more
suitable
for
environment
healthy
biomedical
solutions,
world
way
improves
as
well.
Alexandria Engineering Journal,
Год журнала:
2023,
Номер
87, С. 277 - 299
Опубликована: Дек. 28, 2023
Conjugated
polymers
such
as
polypyrrole,
polyaniline,
and
polythiophene
have
developed
capable
candidates
for
scaffold
fabrication
due
to
their
electrical
conductivity,
tunable
surface
properties,
ability
deliver
bioactive
molecules.
When
blended
with
other
biomaterials
nanoparticles
enables
the
formation
of
composites
that
leverage
advantages
both
components.
The
main
focus
areas
review
include
use
conjugated
polymer-based
(CPCs)
tissue
engineering
e.g.,
neural,
cardiac,
bone,
skin.
Within
each
section,
specific
examples
are
provided
polymer-biomolecule
composite
systems
been
explored
along
a
discussion
composition,
fabrication,
performance
supporting
cell
growth
regeneration.
Finally,
current
challenges
future
perspectives
discussed
in
applying
CPCs
toward
clinically
relevant
tissues
organs.
Overall,
this
comprehensive
covers
fundamental
design
considerations
developing
polymer
scaffolds
emerging
applications
engineering.
Journal of Functional Biomaterials,
Год журнала:
2024,
Номер
15(9), С. 241 - 241
Опубликована: Авг. 23, 2024
The
rising
demand
for
effective
bone
regeneration
has
underscored
the
limitations
of
traditional
methods
like
autografts
and
allografts,
including
donor
site
morbidity
insufficient
biological
signaling.
This
review
examines
nanoparticles
(NPs)
in
tissue
engineering
(TE)
to
address
these
challenges,
evaluating
polymers,
metals,
ceramics,
composites
their
potential
enhance
osteogenesis
angiogenesis
by
mimicking
extracellular
matrix
(ECM)
nanostructure.
involved
synthesizing
characterizing
nanoparticle-based
scaffoldsand
integrating
hydroxyapatite
(HAp)
with
polymers
mechanical
properties
osteogenic
potential.
results
showed
that
NPs
significantly
promote
cell
growth,
differentiation,
formation,
carbon-based
graphene
carbon
nanotubes
showing
promise.
offer
versatile,
biocompatible,
customizable
scaffolds
drug
delivery
support
repair.
Despite
promising
results,
challenges
cytotoxicity,
biodistribution,
immune
responses
remain.
Addressing
issues
through
surface
modifications
biocompatible
molecules
can
improve
biocompatibility
efficacy
nanomaterials.
Future
research
should
focus
on
long-term
vivo
studies
assess
safety
NP-based
explore
synergistic
effects
other
bioactive
or
growth
factors.
underscores
transformative
advancing
BTE
calls
further
optimize
technologies
clinical
applications.
