Novel Microemulsion Containing Benzocaine and Fusidic Acid Simultaneously: Formulation, Characterization, and In Vitro Evaluation for Wound Healing

AAPS PharmSciTech, Год журнала: 2024, Номер 25(3)

Опубликована: Март 5, 2024

Abstract Modern drug carrier technologies, such as microemulsions with small droplet sizes and high surface areas, improve the ability of low water solubility active ingredients to permeate localize. The goal this study was create microemulsion formulations for wound healing that contained both fusidic acid (FA), an antibacterial agent, benzocaine (BNZ), a local anesthetic. Studies on characterization were carried out, including viscosity, size, zeta potential. drug-loaded had stable structure –3.014 ± 1.265 mV potential 19.388 0.480 nm size. In in vitro release ex vivo permeability studies, compared Fucidin cream oily BNZ solution. According from solution showed similar profile ( p > 0.05), while FA higher < 0.001). presented lower permeation 0.05) ingredients, other hand, provided accumulation control preparations. Moreover, according results activity, indicated dose-dependent highest activity at concentrations. To best our knowledge, developed BNZ- FA-loaded would be promising candidate new opportunities thanks present which have solubility, single formulation achieved than Graphical

Язык: Английский

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Fabrication and characterization of porous pectin-based aerogels for drug delivery

Carbohydrate Polymer Technologies and Applications, Год журнала: 2024, Номер 7, С. 100499 - 100499

Опубликована: Апрель 10, 2024

Aerogels are renowned for their exceptional characteristics such as high porosity and ultra-low density. Among these, pectin aerogels, offering biodegradability, low toxicity, versatility, prominent candidates innovative biomedical materials. This study focused on synthesizing pectin-based aerogels carriers ibuprofen diclofenac sodium. Hydrogels were formed by combining a methoxy with calcium chloride solution, followed dehydration drying using either supercritical carbon dioxide (scCO2) or freeze-drying. Comparative analysis showed scCO2-dried exhibited slightly less shrinkage (0.27%) than freeze-dried counterparts. Both types mesoporous characteristics. However, demonstrated higher specific surface area, pore volume, smaller diameter. FTIR spectra indicated no interaction between the drugs aerogels. The loading of in scCO2-dried, at 90, 95, 100 bar 60.0%, 59.9%, 52.1%, respectively, solution sodium was 38.37%. At bar, ibuprofen-loaded released 90.0%, 84.0%, 75.5%, respectively. release sodium-loaded, 88.4%. Korsmeyer-Peppas model fitted both sodium, indicating is mainly driven diffusion.

Язык: Английский

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A hybrid structure based on silk fibroin/PVA nanofibers and alginate/gum tragacanth hydrogel embedded with cardamom extract

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Июнь 18, 2024

Abstract Hybrid structures made of natural-synthetic polymers have been interested due to high biological features combining promising physical–mechanical properties. In this research, a hybrid dressing consisting silk fibroin (SF)/polyvinyl alcohol (PVA) nanofibers and sodium alginate (SA)/gum tragacanth (GT) hydrogel incorporating cardamom extract as an antibacterial agent was prepared. Accordingly, SF extracted from cocoons followed by electrospinning in blend form with PVA (SF/PVA ratio: 1:1) under the voltage 18 kV distances 15 cm. The SEM images confirmed formation uniform, bead free fibers average diameter 199 ± 28 nm. FTIR XRD results revealed successful extraction preparation mixed fibrous mats. Next, oil extract-loaded SA/GT prepared nanofibrous structure placed on surface hydrogel. analysis depicted uniform morphology desirable matching between two layers. TGA showed desired thermal stability. swelling ratio found be 1251% after 24 h for drug released without any initial burst. MTT assay cell attachment favorable biocompatibility proliferation samples containing extract, activity values 85.35% against S. aureus 75% E. coli were obtained well. that engineered nanofibrous-hydrogel film could candidate wound healing applications skin tissue engineering.

Язык: Английский

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Valorised Calcium-Rich Biomass from Fish Waste and Eggshells in the Fabrication of Antibacterial Scaffold for Wound Healing Applications: A Review

Waste and Biomass Valorization, Год журнала: 2023, Номер 15(4), С. 1917 - 1941

Опубликована: Ноя. 15, 2023

Язык: Английский

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Asymmetric chitosan-derivative/carboxymethylcellulose layer-by-layer film combining antimicrobial and vascular regeneration for the repair of infected wounds

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 269, С. 132031 - 132031

Опубликована: Май 3, 2024

Язык: Английский

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