bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Март 19, 2024
ABSTRACT
Background
The
development
of
nanocarriers
with
precise
control
over
drug
release
is
crucial
for
targeted
therapy.
This
study
focuses
on
the
design
and
optimization
pH-sensitive
gelatin/perfluorohexane
(PFH)
nanodroplets
loaded
berberine
chloride,
a
model
relevant
to
traditional
Chinese
medicine.
Subjects
Methods
Nanodroplets
were
prepared
using
an
emulsion
technique,
parameters
including
homogenization
rate,
polymer
concentration,
surfactant,
drug,
perfluorocarbon
conte
nt.
Results
optimized
formulation
resulted
in
mean
particle
size
281.7
nm
encapsulation
efficiency
66.8
±
1.7%.
Characterization
studies
confirmed
successful
pH-responsive
behavior.
Ultrasound
stimulation
significantly
enhanced
release,
150
kHz
frequency
proving
more
effective
than
1
MHz.
Stability
demonstrated
prolonged
stability
one
month
at
4°C.
Following
10
minutes
ultrasound
irradiation,
exhibited
89.4%
cumulative
release.
Conclusions
In
conclusion,
these
show
potential
delivering
chloride
controlled
manner,
connecting
medicine
contemporary
delivery
methods.
Journal of Biomaterials Science Polymer Edition,
Год журнала:
2024,
Номер
35(14), С. 2250 - 2274
Опубликована: Июль 3, 2024
Cancer
is
ranked
among
the
top
causes
of
mortality
throughout
world.
Conventional
therapies
are
associated
with
toxicity
and
undesirable
side
effects,
rendering
them
unsuitable
for
prolonged
use.
Additionally,
there
a
high
occurrence
resistance
to
anticancer
drugs
recurrence
in
certain
circumstances.
Hence,
it
essential
discover
potent
that
exhibit
specificity
minimal
unwanted
effects.
Curcumin,
polyphenol
derivative,
present
turmeric
plant
(Curcuma
longa
L.)
has
chemopreventive,
anticancer,
radio-,
chemo-sensitizing
activities.
Curcumin
exerts
its
anti-tumor
effects
on
cancer
cells
by
modulating
disrupted
cell
cycle
through
p53-dependent,
p53-independent,
cyclin-dependent
mechanisms.
This
review
provides
summary
formulations
curcumin
based
nanospheres,
since
increasing
interest
medicinal
usage
treating
malignancies
tumors.
Nanospheres
composed
dense
polymeric
matrix,
have
size
ranging
from
10
200
nm.
Lactic
acid
polymers,
glycolic
or
mixtures
them,
together
poly
(methyl
methacrylate),
primarily
used
as
matrices
nanospheres.
suitable
local,
oral,
systemic
delivery
due
their
minuscule
particle
size.
The
majority
nanospheres
created
using
polymers
both
biocompatible
biodegradable.
Previous
investigations
shown
use
nanosphere
method
can
enhance
tumor
targeting,
therapeutic
efficacy,
biocompatibility
different
agents.
Moreover,
these
be
easily
taken
up
mammalian
cells.
discusses
many
treatment.
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease,
Год журнала:
2024,
Номер
1871(3), С. 167637 - 167637
Опубликована: Дек. 23, 2024
With
few
viable
treatment
options,
glioblastoma
(GBM)
is
still
one
of
the
most
aggressive
and
deadly
types
brain
cancer.
Recent
developments
in
lipidomics
have
demonstrated
potential
lipid
metabolism
as
a
therapeutic
target
GBM.
The
thorough
examination
lipids
biological
systems,
or
lipidomics,
essential
to
comprehending
changed
profiles
found
GBM,
which
are
linked
tumor's
ability
grow,
survive,
resist
treatment.
use
drug
delivery
discovery
examined
this
study,
focusing
on
how
it
may
be
used
find
new
biomarkers,
create
multi-target
directed
ligands,
improve
systems.
We
also
cover
FDA-approved
medications,
clinical
trials
that
lipid-targeted
medicines,
integration
with
other
omics
technologies.
This
study
emphasizes
possible
tool
developing
more
effective
methods
for
GBM
by
exploring
various
lipid-centric
techniques.
arXiv (Cornell University),
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Background:
The
development
of
smart
nanocarriers
that
enable
controlled
drug
release
in
response
to
internal
and
external
triggers
is
an
emerging
approach
for
targeted
therapy.
This
study
focused
on
designing
pH-sensitive,
ultrasound-responsive
gelatin/perfluorohexane
(PFH)
nanodroplets
loaded
with
berberine
chloride
as
a
model
drug.
Results:The
were
prepared
using
emulsion
technique
optimized
by
varying
process
parameters
like
homogenization
rate,
polymer
concentration,
surfactant,
drug,
perfluorocarbon
content.
optimal
formulation
yielded
particle
size
281.7
nm,
encapsulation
efficiency
66.8+-
1.7%,
passive
15.4+-
0.2%
within
24
hours.
Characterization
confirmed
successful
pH-responsive
behavior.
Ultrasound
stimulation
significantly
enhanced
release,
150
kHz
being
more
effective
than
1
MHz
triggering
acoustic
droplet
vaporization
while
minimizing
heat
generation.
After
10
minutes
radiation,
the
showed
89.4%
cumulative
release.
displayed
stability
over
one
month
at
4{\deg}C.
Conclusions:
Overall,
dual-triggered
demonstrate
excellent
potential
delivery
chloride.
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Фев. 14, 2024
Abstract
The
development
of
smart
nanocarriers
that
enable
controlled
drug
release
in
response
to
internal
and
external
triggers
is
an
emerging
approach
for
targeted
therapy.
This
study
focused
on
designing
pH-sensitive,
ultrasound-responsive
gelatin/perfluorohexane
(PFH)
nanodroplets
loaded
with
berberine
chloride
as
a
model
drug.
were
prepared
using
emulsion
technique
optimized
by
varying
process
parameters
like
homogenization
rate,
polymer
concentration,
surfactant,
drug,
perfluorocarbon
content.
optimal
formulation
yielded
particle
size
281.7
nm,
encapsulation
efficiency
66.8
±
1.7,
passive
15.4
0.2
within
24
hours.
Characterization
confirmed
successful
pH-responsive
behavior.
Ultrasound
stimulation
significantly
enhanced
release,
150
kHz
being
more
effective
than
1
MHz
triggering
acoustic
droplet
vaporization
while
minimizing
heat
generation.
After
10
minutes
radiation,
the
showed
89.4%
cumulative
release.
displayed
stability
over
one
month
at
4°C.
Overall,
dual-triggered
demonstrate
excellent
potential
delivery
chloride.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Март 19, 2024
ABSTRACT
Background
The
development
of
nanocarriers
with
precise
control
over
drug
release
is
crucial
for
targeted
therapy.
This
study
focuses
on
the
design
and
optimization
pH-sensitive
gelatin/perfluorohexane
(PFH)
nanodroplets
loaded
berberine
chloride,
a
model
relevant
to
traditional
Chinese
medicine.
Subjects
Methods
Nanodroplets
were
prepared
using
an
emulsion
technique,
parameters
including
homogenization
rate,
polymer
concentration,
surfactant,
drug,
perfluorocarbon
conte
nt.
Results
optimized
formulation
resulted
in
mean
particle
size
281.7
nm
encapsulation
efficiency
66.8
±
1.7%.
Characterization
studies
confirmed
successful
pH-responsive
behavior.
Ultrasound
stimulation
significantly
enhanced
release,
150
kHz
frequency
proving
more
effective
than
1
MHz.
Stability
demonstrated
prolonged
stability
one
month
at
4°C.
Following
10
minutes
ultrasound
irradiation,
exhibited
89.4%
cumulative
release.
Conclusions
In
conclusion,
these
show
potential
delivering
chloride
controlled
manner,
connecting
medicine
contemporary
delivery
methods.
