Dual-trigger release of berberine chloride from the Gelatin/Perfluorohexane core-shell structure DOI Creative Commons
Mahshid Givarian, Fathollah Moztarzadeh, Maryam Ghaffari

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Фев. 14, 2024

Abstract The development of smart nanocarriers that enable controlled drug release in response to internal and external triggers is an emerging approach for targeted therapy. This study focused on designing pH-sensitive, ultrasound-responsive gelatin/perfluorohexane (PFH) nanodroplets loaded with berberine chloride as a model drug. were prepared using emulsion technique optimized by varying process parameters like homogenization rate, polymer concentration, surfactant, drug, perfluorocarbon content. optimal formulation yielded particle size 281.7 nm, encapsulation efficiency 66.8 ± 1.7, passive 15.4 0.2 within 24 hours. Characterization confirmed successful pH-responsive behavior. Ultrasound stimulation significantly enhanced release, 150 kHz being more effective than 1 MHz triggering acoustic droplet vaporization while minimizing heat generation. After 10 minutes radiation, the showed 89.4% cumulative release. displayed stability over one month at 4°C. Overall, dual-triggered demonstrate excellent potential delivery chloride.

Язык: Английский

Nanospheres for curcumin delivery as a precision nanomedicine in cancer therapy DOI
Maryam Mahjoubin‐Tehran, Samaneh Rezaei, Prashant Kesharwani

и другие.

Journal of Biomaterials Science Polymer Edition, Год журнала: 2024, Номер 35(14), С. 2250 - 2274

Опубликована: Июль 3, 2024

Cancer is ranked among the top causes of mortality throughout world. Conventional therapies are associated with toxicity and undesirable side effects, rendering them unsuitable for prolonged use. Additionally, there a high occurrence resistance to anticancer drugs recurrence in certain circumstances. Hence, it essential discover potent that exhibit specificity minimal unwanted effects. Curcumin, polyphenol derivative, present turmeric plant (Curcuma longa L.) has chemopreventive, anticancer, radio-, chemo-sensitizing activities. Curcumin exerts its anti-tumor effects on cancer cells by modulating disrupted cell cycle through p53-dependent, p53-independent, cyclin-dependent mechanisms. This review provides summary formulations curcumin based nanospheres, since increasing interest medicinal usage treating malignancies tumors. Nanospheres composed dense polymeric matrix, have size ranging from 10 200 nm. Lactic acid polymers, glycolic or mixtures them, together poly (methyl methacrylate), primarily used as matrices nanospheres. suitable local, oral, systemic delivery due their minuscule particle size. The majority nanospheres created using polymers both biocompatible biodegradable. Previous investigations shown use nanosphere method can enhance tumor targeting, therapeutic efficacy, biocompatibility different agents. Moreover, these be easily taken up mammalian cells. discusses many treatment.

Язык: Английский

Процитировано

1
Lipidomics-driven drug discovery and delivery strategies in glioblastoma DOI Creative Commons
Xiaohui Weng, Michael Gonzalez, Jeannes Angelia

и другие.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Год журнала: 2024, Номер 1871(3), С. 167637 - 167637

Опубликована: Дек. 23, 2024

With few viable treatment options, glioblastoma (GBM) is still one of the most aggressive and deadly types brain cancer. Recent developments in lipidomics have demonstrated potential lipid metabolism as a therapeutic target GBM. The thorough examination lipids biological systems, or lipidomics, essential to comprehending changed profiles found GBM, which are linked tumor's ability grow, survive, resist treatment. use drug delivery discovery examined this study, focusing on how it may be used find new biomarkers, create multi-target directed ligands, improve systems. We also cover FDA-approved medications, clinical trials that lipid-targeted medicines, integration with other omics technologies. This study emphasizes possible tool developing more effective methods for GBM by exploring various lipid-centric techniques.

Язык: Английский

Процитировано

1
DESIGN AND DEVELOPMENT OF CURCUMIN LOADED CHIA SEED MUCILAGE BASED ELECTROSPRAYED NANOPARTICLES: IN VITRO-EX VIVO CHARACTERIZATION DOI Open Access

SWAPNIL THAKARE,

Ashish Prakash Gorle

Cellulose Chemistry and Technology, Год журнала: 2024, Номер 58(3-4), С. 233 - 247

Опубликована: Май 15, 2024

Chia seed mucilage (CSM) has recently been reported as a biocompatible polymeric matrix for drug delivery. Curcumin (CUR), an active phytoconstituent widely recognized managing colon and other types of cancer, faces limitations, such poor water solubility low bioavailability. Hence, this study focuses on developing CUR-loaded CSM-based electrosprayed nanoparticles (ENPs) using the electrospraying technology. The particle size zeta potential optimized batch (F9) were measured at 82.20 nm 22.39 mV, respectively. Solubility studies confirmed that CUR-ENPs exhibit higher compared to bare CUR, with 92.25% release in 12 h (pH 5.8). designed showed good biocompatibility normal FHC-CRL-1831 cell lines over CUR. Moreover, demonstrated reduction % viability preferred HCT116 line colorectal cancer In conclusion, demonstrate improved

Язык: Английский

Процитировано

0
Dual-trigger release of berberine chloride from the Gelatin/Perfluorohexane core-shell structure DOI Creative Commons
Mahshid Givarian, Fathollah Moztarzadeh, Maryam Ghaffari

и другие.

arXiv (Cornell University), Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Background: The development of smart nanocarriers that enable controlled drug release in response to internal and external triggers is an emerging approach for targeted therapy. This study focused on designing pH-sensitive, ultrasound-responsive gelatin/perfluorohexane (PFH) nanodroplets loaded with berberine chloride as a model drug. Results:The were prepared using emulsion technique optimized by varying process parameters like homogenization rate, polymer concentration, surfactant, drug, perfluorocarbon content. optimal formulation yielded particle size 281.7 nm, encapsulation efficiency 66.8+- 1.7%, passive 15.4+- 0.2% within 24 hours. Characterization confirmed successful pH-responsive behavior. Ultrasound stimulation significantly enhanced release, 150 kHz being more effective than 1 MHz triggering acoustic droplet vaporization while minimizing heat generation. After 10 minutes radiation, the showed 89.4% cumulative release. displayed stability over one month at 4{\deg}C. Conclusions: Overall, dual-triggered demonstrate excellent potential delivery chloride.

Язык: Английский

Процитировано

0
Dual-trigger release of berberine chloride from the Gelatin/Perfluorohexane core-shell structure DOI Creative Commons
Mahshid Givarian, Fathollah Moztarzadeh, Maryam Ghaffari

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Фев. 14, 2024

Abstract The development of smart nanocarriers that enable controlled drug release in response to internal and external triggers is an emerging approach for targeted therapy. This study focused on designing pH-sensitive, ultrasound-responsive gelatin/perfluorohexane (PFH) nanodroplets loaded with berberine chloride as a model drug. were prepared using emulsion technique optimized by varying process parameters like homogenization rate, polymer concentration, surfactant, drug, perfluorocarbon content. optimal formulation yielded particle size 281.7 nm, encapsulation efficiency 66.8 ± 1.7, passive 15.4 0.2 within 24 hours. Characterization confirmed successful pH-responsive behavior. Ultrasound stimulation significantly enhanced release, 150 kHz being more effective than 1 MHz triggering acoustic droplet vaporization while minimizing heat generation. After 10 minutes radiation, the showed 89.4% cumulative release. displayed stability over one month at 4°C. Overall, dual-triggered demonstrate excellent potential delivery chloride.

Язык: Английский

Процитировано

0