Deleted Journal,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 12, 2024
A
bio-based
hydrogel
is
a
complex
compound
that
consists
of
natural
biomaterials
and
widely
applied
for
various
therapeutic
purposes.
The
modification
from
traditional
to
reformulated
hydrogels
has
gained
place
at
biomedical
field
due
the
growth
benefits
such
as
drug
delivery,
tissue
engineering,
regenerative
medicine.
Moreover,
increasing
global
demand
resulted
in
worldwide
shortage
mass
formulations
raised
environmental
awareness.
By
using
instead
synthetic
ones,
these
minimize
their
negative
effects
on
environment
while
simultaneously
maximizing
successful
execution
product.
However,
mechanisms
governing
degradation
bioactivity
hydrogels,
which
dictate
release
profiles,
stability,
effectiveness,
are
not
yet
comprehensively
understood.
Therefore,
by
analyzing
recent
progress
ongoing
challenges,
this
review
will
reveal
how
advanced
quietly
transforming
future
healthcare
offering
novel
solutions
pressing
health
problems.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Feb. 14, 2024
Abstract
The
development
of
smart
nanocarriers
that
enable
controlled
drug
release
in
response
to
internal
and
external
triggers
is
an
emerging
approach
for
targeted
therapy.
This
study
focused
on
designing
pH-sensitive,
ultrasound-responsive
gelatin/perfluorohexane
(PFH)
nanodroplets
loaded
with
berberine
chloride
as
a
model
drug.
were
prepared
using
emulsion
technique
optimized
by
varying
process
parameters
like
homogenization
rate,
polymer
concentration,
surfactant,
drug,
perfluorocarbon
content.
optimal
formulation
yielded
particle
size
281.7
nm,
encapsulation
efficiency
66.8
±
1.7,
passive
15.4
0.2
within
24
hours.
Characterization
confirmed
successful
pH-responsive
behavior.
Ultrasound
stimulation
significantly
enhanced
release,
150
kHz
being
more
effective
than
1
MHz
triggering
acoustic
droplet
vaporization
while
minimizing
heat
generation.
After
10
minutes
radiation,
the
showed
89.4%
cumulative
release.
displayed
stability
over
one
month
at
4°C.
Overall,
dual-triggered
demonstrate
excellent
potential
delivery
chloride.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: March 19, 2024
ABSTRACT
Background
The
development
of
nanocarriers
with
precise
control
over
drug
release
is
crucial
for
targeted
therapy.
This
study
focuses
on
the
design
and
optimization
pH-sensitive
gelatin/perfluorohexane
(PFH)
nanodroplets
loaded
berberine
chloride,
a
model
relevant
to
traditional
Chinese
medicine.
Subjects
Methods
Nanodroplets
were
prepared
using
an
emulsion
technique,
parameters
including
homogenization
rate,
polymer
concentration,
surfactant,
drug,
perfluorocarbon
conte
nt.
Results
optimized
formulation
resulted
in
mean
particle
size
281.7
nm
encapsulation
efficiency
66.8
±
1.7%.
Characterization
studies
confirmed
successful
pH-responsive
behavior.
Ultrasound
stimulation
significantly
enhanced
release,
150
kHz
frequency
proving
more
effective
than
1
MHz.
Stability
demonstrated
prolonged
stability
one
month
at
4°C.
Following
10
minutes
ultrasound
irradiation,
exhibited
89.4%
cumulative
release.
Conclusions
In
conclusion,
these
show
potential
delivering
chloride
controlled
manner,
connecting
medicine
contemporary
delivery
methods.
arXiv (Cornell University),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
Background:
The
development
of
smart
nanocarriers
that
enable
controlled
drug
release
in
response
to
internal
and
external
triggers
is
an
emerging
approach
for
targeted
therapy.
This
study
focused
on
designing
pH-sensitive,
ultrasound-responsive
gelatin/perfluorohexane
(PFH)
nanodroplets
loaded
with
berberine
chloride
as
a
model
drug.
Results:The
were
prepared
using
emulsion
technique
optimized
by
varying
process
parameters
like
homogenization
rate,
polymer
concentration,
surfactant,
drug,
perfluorocarbon
content.
optimal
formulation
yielded
particle
size
281.7
nm,
encapsulation
efficiency
66.8+-
1.7%,
passive
15.4+-
0.2%
within
24
hours.
Characterization
confirmed
successful
pH-responsive
behavior.
Ultrasound
stimulation
significantly
enhanced
release,
150
kHz
being
more
effective
than
1
MHz
triggering
acoustic
droplet
vaporization
while
minimizing
heat
generation.
After
10
minutes
radiation,
the
showed
89.4%
cumulative
release.
displayed
stability
over
one
month
at
4{\deg}C.
Conclusions:
Overall,
dual-triggered
demonstrate
excellent
potential
delivery
chloride.
Cellulose Chemistry and Technology,
Journal Year:
2024,
Volume and Issue:
58(3-4), P. 233 - 247
Published: May 15, 2024
Chia
seed
mucilage
(CSM)
has
recently
been
reported
as
a
biocompatible
polymeric
matrix
for
drug
delivery.
Curcumin
(CUR),
an
active
phytoconstituent
widely
recognized
managing
colon
and
other
types
of
cancer,
faces
limitations,
such
poor
water
solubility
low
bioavailability.
Hence,
this
study
focuses
on
developing
CUR-loaded
CSM-based
electrosprayed
nanoparticles
(ENPs)
using
the
electrospraying
technology.
The
particle
size
zeta
potential
optimized
batch
(F9)
were
measured
at
82.20
nm
22.39
mV,
respectively.
Solubility
studies
confirmed
that
CUR-ENPs
exhibit
higher
compared
to
bare
CUR,
with
92.25%
release
in
12
h
(pH
5.8).
designed
showed
good
biocompatibility
normal
FHC-CRL-1831
cell
lines
over
CUR.
Moreover,
demonstrated
reduction
%
viability
preferred
HCT116
line
colorectal
cancer
In
conclusion,
demonstrate
improved
Deleted Journal,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 12, 2024
A
bio-based
hydrogel
is
a
complex
compound
that
consists
of
natural
biomaterials
and
widely
applied
for
various
therapeutic
purposes.
The
modification
from
traditional
to
reformulated
hydrogels
has
gained
place
at
biomedical
field
due
the
growth
benefits
such
as
drug
delivery,
tissue
engineering,
regenerative
medicine.
Moreover,
increasing
global
demand
resulted
in
worldwide
shortage
mass
formulations
raised
environmental
awareness.
By
using
instead
synthetic
ones,
these
minimize
their
negative
effects
on
environment
while
simultaneously
maximizing
successful
execution
product.
However,
mechanisms
governing
degradation
bioactivity
hydrogels,
which
dictate
release
profiles,
stability,
effectiveness,
are
not
yet
comprehensively
understood.
Therefore,
by
analyzing
recent
progress
ongoing
challenges,
this
review
will
reveal
how
advanced
quietly
transforming
future
healthcare
offering
novel
solutions
pressing
health
problems.
