Journal of Research in Pharmacy,
Год журнала:
2024,
Номер
29(3), С. 1284 - 1294
Опубликована: Июль 22, 2024
Nicardipine
HCl
as
Monotherapy
or
in
combination
therapy
for
treating
severe
Angina
and
high
blood
pressure.
Its
mechanism
involves
the
relaxation
of
vessels,
thereby
reducing
workload
on
heart
lowering
İt
reduces
myocardial
oxygen
demand
by
after
load
increasing
supply
through
coronary
vaso
dilation.
İn
present
study
solubility
release
various
solvents
was
examined
based
studies
choice
solvent
determined
considering
its
properties.
comparison
method.
is
used
to
treat
Angina,
hypertension,
arterial
relaxation,
vasodilation
so
on.
Currently
marketed
different
Novel
drug
formulations
such
Nanoparticles,
Capsules,
Niosomes,
Hydrogels
pressure
many
analytical
techniques
were
like
HPLC,
GC
GC-MS,
LC-MS
carrying
out
quantitative
qualitative
analyses
are
some
examples
these
developments.
In
this
study,
treated
with
Methanol,
Phosphate
Buffers
PH
3.6
6.8.
A
method
developed
validated
validation
parameters
Linearity,
Accuracy,
Precision,
Specificity,
LOQ,
LOD
etc.,
using
UV-Visible
Spectroscopy.
Results
revealed
that
gives
data
about
precision,
accuracy
Linearity
15-55μg/ml,
Regression
0.998,
LOD,
LOQ.
By
carefully
selecting
suitable
solvents,
we
successfully
established
a
reliable
efficient
determining
estimation
Spectrophotometric
Method
developed,
optimized
Validated
Abstract
Breast
cancer
is
a
complex
and
heterogeneous
disease,
encompassing
various
subtypes
characterized
by
distinct
molecular
features,
clinical
behaviors,
treatment
responses.
Categorization
of
based
on
the
presence
or
absence
estrogen
receptor
(ER),
progesterone
(PR),
human
epidermal
growth
factor
2
(HER2),
leading
to
such
as
luminal
A,
B,
HER2-positive,
triple-negative
breast
(TNBC).
TNBC,
comprising
around
20%
all
cancers,
lacks
expression
ER,
PR,
HER2
receptors,
rendering
it
unresponsive
targeted
therapies
presenting
significant
challenges
in
treatment.
TNBC
associated
with
aggressive
behavior,
high
rates
recurrence,
resistance
chemotherapy.
Tumor
initiation,
progression,
are
attributed
stem
cells
(BCSCs),
which
possess
self-renewal,
differentiation,
tumorigenic
potential.
Surface
markers,
self-renewal
pathways
(Notch,
Wnt,
Hedgehog
signaling),
apoptotic
protein
(Bcl-2),
angiogenesis
inhibition
(VEGF
inhibitors),
immune
modulation
(cytokines,
checkpoint
inhibitors)
among
key
targets
discussed
this
review.
However,
targeting
BCSC
subpopulation
presents
challenges,
including
off-target
effects,
low
solubility,
bioavailability
anti-BCSC
agents.
Nanoparticle-based
offer
promising
approach
target
cellular
processes
implicated
survival
BSCS
TNBC.
In
review,
we
explore
nanocarrier-based
approaches
for
BCSCs
aiming
overcome
these
improve
outcomes
patients.
These
nanoparticle-based
therapeutic
strategies
hold
promise
addressing
gap
delivering
while
minimizing
systemic
toxicity
enhancing
efficacy.
Graphical
abstract
Communications Biology,
Год журнала:
2025,
Номер
8(1)
Опубликована: Фев. 20, 2025
Glycosylation
profoundly
influences
cellular
function,
yet
deciphering
its
intricate
patterns
remains
a
formidable
challenge.
Current
techniques
often
compromise
sensitivity,
multiplexing,
or
the
ability
to
capture
in-situ
cell-to-cell
variations.
To
address
these
limitations,
we
introduce
'Lectin-PAINT,'
super-resolution
imaging
method
enabling
multiplexed
live-cell
visualization
of
glycocalyx
at
single-cell
and
single-molecule
levels.
Lectin-PAINT
leverages
reversible
binding
lectins
specific
carbohydrate
families
perform
point
accumulation
in
nanoscale
topography
(PAINT),
identification,
mapping,
tracking
carbohydrates
with
resolution
beyond
diffraction
limit.
Our
technique
harnesses
tailored
lectin
library,
spanning
key
recognition,
offering
insights
into
their
abundance,
affinity,
mobility.
Through
8-color
imaging,
extract
more
than
350
glycosylation
parameters
resolution,
creating
cell's
'glycotype'
glycan
fingerprint.
We
showcase
power
this
approach
by
glycotyping
categorizing
diverse
set
cancer
cell
types,
shedding
light
on
heterogeneity
variability
cancer.
In
future,
research
will
contribute
fundamental
understanding
changes
due
disease.
International Journal of Applied Pharmaceutics,
Год журнала:
2023,
Номер
unknown, С. 339 - 343
Опубликована: Сен. 7, 2023
Objective:
This
study
aimed
to
develop
a
more
effective
formulation
of
Fluphenazine
(FLP)
for
the
management
psychosis.
Antipsychotics
are
widely
used
treatment
severe
mental
disorders
such
as
schizophrenia
and
bipolar
disorder.
However,
their
clinical
use
is
limited
due
various
side
effects
low
efficacy
in
large
number
patients.
Nanoparticle-based
drug
delivery
systems
have
shown
great
potential
improving
pharmacokinetics
pharmacodynamics
drugs,
including
antipsychotics.
Zinc
oxide
nanoparticles
(ZnO
NPs)
emerged
promising
carrier
unique
physicochemical
properties,
biocompatibility,
toxicity.
Methods:
In
this
study,
we
reported
preparation
characterization
FLU-encapsulated
ZnO
NPs
(FLU-ZnO-NPs)
The
synthesized
FLU-ZnO-NPs
were
characterized
using
techniques,
X-Ray
Diffractometer,
Energy
Dispersive
analysis,
Transmission
Electron
Microscopy,
Zetasizer
(Malvern).
Results:
results
showed
that
had
improved
solubility,
enhanced
bioavailability,
targeted
delivery,
reduced
Conclusion:
development
could
provide
safe
option
patients
with
disorders.
