Comprehensive insights into mechanism of nanotoxicity, assessment methods and regulatory challenges of nanomedicines

Discover Nano, Год журнала: 2024, Номер 19(1)

Опубликована: Окт. 4, 2024

Nanomedicine has the potential to transform healthcare by offering targeted therapies, precise diagnostics, and enhanced drug delivery systems. The National Institutes of Health coined term "nanomedicine" describe use nanotechnology in biological system monitoring, control, diagnosis, treatment. continues receive increasing interest for rationalized therapeutics pharmaceutical agents achieve required response while reducing its side effects. However, as advance, concerns about toxicological effects have also grown. This review explores current state nanomedicine, focusing on types nanoparticles used their associated properties that contribute nanotoxicity. It examines mechanisms through which exert toxicity, encompassing various cellular molecular interactions. Furthermore, it discusses assessment methods employed evaluate nanotoxicity, in-vitro in-vivo models, well emerging techniques. addresses regulatory issues surrounding nanotoxicology, highlighting challenges developing standardized guidelines ensuring secure translation nanomedicine into clinical settings. ethical with understanding safety profile is essential effective therapeutic applications.

Язык: Английский

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Polymeric and non-polymeric oxaliplatin nanomedicine for cancer therapy: A comprehensive review

European Polymer Journal, Год журнала: 2024, Номер 208, С. 112870 - 112870

Опубликована: Фев. 23, 2024

Язык: Английский

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Cerium Oxide Nanoparticles and Their Polymeric Composites: Advancements in Biomedical Applications

Journal of Inorganic and Organometallic Polymers and Materials, Год журнала: 2024, Номер unknown

Опубликована: Июль 27, 2024

Язык: Английский

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Phytonanoparticles as novel drug carriers for enhanced osteogenesis and osseointegration

Discover Nano, Год журнала: 2025, Номер 20(1)

Опубликована: Янв. 16, 2025

Abstract Phytonanoparticles have emerged as a promising class of biomaterials for enhancing bone regeneration and osseointegration, offering unique advantages in biocompatibility, multifunctionality, sustainability. This comprehensive review explores the synthesis, characterization, applications phytonanoparticles tissue engineering. The green synthesis approach, utilizing plant extracts reducing stabilizing agents, yields nanoparticles with intrinsic bioactive properties that can synergistically promote osteogenesis. We examine mechanisms by which phytonanoparticles, particularly those derived from gold, silver, zinc oxide, influence key molecular pathways osteogenesis, including RUNX2 Osterix signaling. discusses advanced strategies phyto-nanoparticle design, such surface functionalization stimuli-responsive release mechanisms, enhance their efficacy applications. Preclinical studies demonstrating improved osteoblast proliferation, differentiation, mineralization are critically analyzed, along emerging clinical data. Despite results, scalability, standardization, regulatory approval challenges persist. also addresses economic environmental implications production. Looking ahead, we identify research directions, developing personalized therapies, combination approaches stem cells or gene delivery, long-term safety assessments. By harnessing power plant-derived nanomaterials, represent an innovative approach to addressing complex regeneration, potential spanning dental, orthopedic, maxillofacial surgery. Graphical abstract

Язык: Английский

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Emerging innovations in vincristine-encapsulated nanoparticles: Pioneering a new era in oncological therapeutics

Journal of Drug Delivery Science and Technology, Год журнала: 2023, Номер 91, С. 105270 - 105270

Опубликована: Дек. 14, 2023

Язык: Английский

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Organic and Biogenic Nanocarriers as Bio-Friendly Systems for Bioactive Compounds’ Delivery: State-of-the Art and Challenges

Materials, Год журнала: 2023, Номер 16(24), С. 7550 - 7550

Опубликована: Дек. 7, 2023

"Green" strategies to build up novel organic nanocarriers with bioperformance are modern trends in nanotechnology. In this way, the valorization of bio-wastes and use living systems develop multifunctional biogenic (OBNs) have revolutionized nanotechnological biomedical fields. This paper is a comprehensive review related OBNs for bioactives' delivery, providing an overview reports on past two decades. first part, several classes bioactive compounds their therapeutic role briefly presented. A broad section dedicated main categories nanocarriers. The major challenges regarding eco-design fate suggested overcome some toxicity-related drawbacks. Future directions opportunities, finding "green" solutions solving problems nanocarriers, outlined final paper. We believe that through review, we will capture attention readers open new perspectives solutions/ideas discovery more efficient ways developing bioperformant transporting agents.

Язык: Английский

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Enhanced Drug Delivery of 5-Fluorouracil Using a GO-PVP-SA Nanocomposite for Targeted Colorectal Cancer Treatment

BioNanoScience, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 23, 2025

Язык: Английский

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Recent advancements in nanoparticles for cancer treatment

Medical Oncology, Год журнала: 2025, Номер 42(3)

Опубликована: Фев. 10, 2025

Язык: Английский

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Fabrication and Characterization of Curcumin and Piperine Loaded CMTG/rGO Electrospun for Breast Cancer Treatment

BioNanoScience, Год журнала: 2025, Номер 15(2)

Опубликована: Март 7, 2025

Язык: Английский

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Transforming growth factor alpha: Key insights into physiological role, cancer therapeutics, and biomarker potential (A review)

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 143212 - 143212

Опубликована: Апрель 1, 2025

Язык: Английский

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