Revista da Associação Médica Brasileira, Год журнала: 2024, Номер 70(12)
Опубликована: Янв. 1, 2024
Язык: Английский
Cancer Cell International, Год журнала: 2025, Номер 25(1)
Опубликована: Янв. 27, 2025
Theranostics is a way of treating illness that blends medicine with testing. Specific characteristics should be present in the best theranostic agents for cancer: (1) drugs safe and non-toxic; (2) they able to treat cancer selectively; (3) build up only cancerous tissue. Liposomes (LPs) are one most efficient drug delivery methods based on nanotechnology. Stealth LPs commercial have recently had an impact treatment. Using valuable information from each imaging technique, along multimodality functionality liposomal therapeutic agents, makes them very appealing personalized monitoring how well working against vivo predicting therapies will work. On other hand, their use as nanoparticle systems currently research development phase. Nanoscale system innovation has made LP-nanoparticle hybrid structures useful combining methods. LP-hybrid nanoparticles better at killing cells than LP counterparts, making excellent options vitro applications. Hybrid liposomes (HLs) could used future carriers find targets. This would combine features synthetic biological systems. Overarchingly, this article provided comprehensive overview many types detection, therapy, analysis. An evaluation pros cons HLs detection treatment also been conducted. The study included recent significant We conclude by outlining potential benefits drawbacks approach concurrent different malignancies, its prospects.
Язык: Английский
Процитировано
4
Nanomaterials, Год журнала: 2025, Номер 15(2), С. 106 - 106
Опубликована: Янв. 12, 2025
Niobium nanoparticles (NbNPs) have gained attention as promising materials in biomedical applications due to their exceptional biocompatibility, corrosion resistance, and versatility. These offer potential drug delivery, imaging, tissue engineering, where nanoscale properties allow precise interactions with biological systems. Among niobium-based nanomaterials, niobium pentoxide (Nb2O5) is the most extensively studied its chemical stability, bioactivity, optical properties. Nb2O5 shown significant catalysis, biosensing, photodynamic therapy, stability reactivity make them ideal for functionalization advanced applications. Despite these advantages, challenges remain regarding biodegradability long-term retention of NbNPs Their accumulation tissues can lead risks such chronic inflammation or toxicity, emphasizing importance designing controlled clearance biodegradability. Surface modifications, coatings biocompatible polymers, demonstrated ability mitigate while enhancing therapeutic efficacy. This review provides a comprehensive overview NbNPs, focus on Nb2O5, highlighting unique properties, current applications, limitations. By addressing remaining challenges, this work aims guide development safer more effective nanomaterials future medical innovations.
Язык: Английский
Процитировано
1
Nano Trends, Год журнала: 2025, Номер unknown, С. 100087 - 100087
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
1
Medicine in Drug Discovery, Год журнала: 2025, Номер unknown, С. 100204 - 100204
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
1
Journal of Science Advanced Materials and Devices, Год журнала: 2025, Номер unknown, С. 100875 - 100875
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
1
RSC Advances, Год журнала: 2025, Номер 15(10), С. 7799 - 7825
Опубликована: Янв. 1, 2025
Onychomycosis significantly impacts approximately 20% of the global population.
Язык: Английский
Процитировано
0
Metabolites, Год журнала: 2025, Номер 15(3), С. 201 - 201
Опубликована: Март 13, 2025
Background: Tumor cells engage in continuous self-replication by utilizing a large number of resources and capabilities, typically within an aberrant metabolic regulatory network to meet their own demands. This dysregulation leads the formation tumor microenvironment (TME) most solid tumors. Nanomedicines, due unique physicochemical properties, can achieve passive targeting certain tumors through enhanced permeability retention (EPR) effect, or active deliberate design optimization, resulting accumulation TME. The use nanomedicines target critical pathways holds significant promise. However, requires careful selection relevant drugs materials, taking into account multiple factors. traditional trial-and-error process is relatively inefficient. Artificial intelligence (AI) integrate big data evaluate delivery efficiency nanomedicines, thereby assisting nanodrugs. Methods: We have conducted detailed review key papers from databases, such as ScienceDirect, Scopus, Wiley, Web Science, PubMed, focusing on reprogramming, mechanisms action development metabolism, application AI empowering nanomedicines. integrated content present current status research metabolism potential future directions this field. Results: Nanomedicines possess excellent TME which be utilized disrupt cells, including glycolysis, lipid amino acid nucleotide metabolism. disruption selective killing disturbance Extensive has demonstrated that AI-driven methodologies revolutionized nanomedicine development, while concurrently enabling precise identification molecular regulators involved oncogenic reprogramming pathways, catalyzing transformative innovations targeted cancer therapeutics. Conclusions: great Additionally, will accelerate discovery metabolism-related targets, empower optimization help minimize toxicity, providing new paradigm for development.
Язык: Английский
Процитировано
0
Discover Nano, Год журнала: 2025, Номер 20(1)
Опубликована: Март 26, 2025
Berberine, also known as Xiaobojian (XBJ), is a quaternary ammonium alkaloid isolated from the traditional Chinese medicine Coptis chinensis, and main effective ingredient for antibacterial purpose. This work systematically reviewed recent researches on XBJ in whole range of delivery technologies. Compared with monomer administration, other forms drug such tablets, pellets, polymer system, lipid superdeformed vesicles nanocrystallization or emulsification some special substances, will increase absorption XBJ. can be administered through various carriers, including oral administration topical application. The importance carrier mainly reflected wide application prospects, pharmacological effects, improving efficacy.
Язык: Английский
Процитировано
0
Small Methods, Год журнала: 2025, Номер unknown
Опубликована: Март 30, 2025
Osteoarthritis (OA) is the most prevalent degenerative joint disorder, characterized by progressive degradation, pain, and diminished mobility, all of which collectively impair patients' quality life escalate healthcare expenditures. Current treatment options are often inadequate due to limited efficacy, adverse side effects, temporary symptom relief, underscoring urgent need for more effective therapeutic strategies. Recent advancements in nanomaterials nanomedicines offer promising solutions improving drug bioavailability, reducing effects providing targeted benefits. This review critically examines pathogenesis OA, highlights limitations existing treatments, explores latest innovations intelligent design OA therapy, with an emphasis on their engineered properties, mechanisms, translational potential clinical application. By compiling recent findings, this work aims inspire further exploration innovation nanomedicine, ultimately advancing development personalized therapies.
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(8), С. 3522 - 3522
Опубликована: Апрель 9, 2025
Neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s (PD), multiple sclerosis (MS), amyotrophic lateral (ALS) and Huntington’s (HD), represent a significant challenge to global health due their progressive nature the absence of curative treatments. These disorders are characterized by oxidative stress, protein misfolding, neuroinflammation, which collectively contribute neuronal damage death. Recent advancements in nanotechnology have introduced nanozymes—engineered nanomaterials that mimic enzyme-like activities—as promising therapeutic agents. This review explores multifaceted roles nanozymes combating stress inflammation neurodegenerative conditions. By harnessing potent antioxidant properties, can effectively scavenge reactive oxygen species (ROS) restore redox balance, thereby protecting function. Their ability modify surface properties enhances targeted delivery biocompatibility, making them suitable for various biomedical applications. In this review, we highlight recent findings on design, functionality, potential nanozymes, emphasizing dual role addressing pathological features such as aggregation. synthesis current research underscores innovative proactive strategy halt progression improve patient outcomes disorders.
Язык: Английский
Процитировано
0