Collagen-Based Nanoparticles as Drug Delivery System in Wound Healing Applications

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 11321 - 11341

Опубликована: Ноя. 1, 2024

Background: Conventional wound dressings often adhere to wounds and can cause secondary injury due their lack of anti-inflammatory antibacterial properties. In contrast, collagen-based nanoparticles (NPs) as drug delivery systems exhibit both biocompatibility biodegradability, presenting a promising avenue for accelerating healing processes. Aims Study: This review aims provide comprehensive overview the mechanisms involved in healing, description attributes ideal dressings, understanding efficacy collagen, exploring NPs-mediated therapy, detailing synthesis fabrication techniques NPs, delineating applications various NPs infused on healing. Methodology: synthesizes relevant literature from reputable databases such Scopus, Science Direct, Google Scholar, PubMed. Results: A diverse array including nanopolymers, metal nanoemulsions, nanoliposomes, nanofibers, demonstrate pronounced promoting closure tissue regeneration. The incorporation has not only become an agent therapeutics but also actively contributes cascade. Conclusion: conclusion, brief, use presents compelling strategy expediting Keywords: nanoparticles, techniques, collagen

Язык: Английский

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Revealing the promising era of silk-based nanotherapeutics: a ray of hope for chronic wound healing treatment

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 31, 2025

Язык: Английский

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Wound dressings using electrospun nanofibers: mechanisms, applications, and future directions

European Polymer Journal, Год журнала: 2025, Номер unknown, С. 113900 - 113900

Опубликована: Март 1, 2025

Язык: Английский

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Characterization and Biological Evaluation of Composite Nanofibrous Membranes Prepared from Hemp Salmon (Oncorhynchus keta) Skin Collagen

Cells, Год журнала: 2025, Номер 14(7), С. 537 - 537

Опубликована: Апрель 3, 2025

Aquatic collagen, a natural macromolecule protein with excellent biocompatibility, has attracted attention in the field of medical materials. Compared to mammalian aquatic collagen offers unique advantages, including absence zoonotic disease risks and religious concerns. In this study, salmon skin nanofiber membrane (GS) was prepared by electrostatic spinning. Then, combined silk sericin (SS) sodium hyaluronate (HA) fabricate composite (GF) using spinning technology. GF membranes were further cross-linked (GFL) for use mouse wound healing model. The physicochemical properties biocompatibility GS, GF, GFL evaluated. FTIR analysis revealed that exhibited more stable secondary structure compared GS GF. DSC TGA results indicated had highest thermal stability, followed Cytotoxicity tests confirmed non-cytotoxic, showing cell viability rate 175.23 ± 1.77%. model, group achieved nearly complete day 14 (98 0.1%), 76.04 0.01% blank group. Measurement TGF-β1 VEGF levels tissue on progressed late stage healing, whereas remained early stage. These suggest holds significant potential as biomaterial applications.

Язык: Английский

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Silk fibroin: An innovative protein macromolecule-based hydrogel/scaffold revolutionizing breast cancer treatment and diagnosis – Mechanisms, advancements, and targeting capabilities

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142870 - 142870

Опубликована: Апрель 1, 2025

Язык: Английский

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Preparation and Characterization of the Pla: Ga: Zno Nanofibers-Based Drug Delivery System

Опубликована: Янв. 1, 2025

Язык: Английский

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Leveraging Large Language Models for Accelerated Learning and Innovation in Biogenic Tissue-Engineered Vascular Grafts

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106935 - 106935

Опубликована: Апрель 1, 2025

Язык: Английский

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