Vanillin and IGF1-loaded dual-layer multifunctional wound dressing with micro-nanofibrous structure for full-thickness wound healing acceleration

International Journal of Pharmaceutics, Год журнала: 2025, Номер 671, С. 125231 - 125231

Опубликована: Янв. 15, 2025

Язык: Английский

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Antibacterial and wound healing stimulant nanofibrous dressing consisting of soluplus and soy protein isolate loaded with mupirocin

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Ноя. 2, 2024

Abstract Severe cutaneous injuries may not heal spontaneously and necessitate the use of supplementary therapeutic methods. Electrospun nanofibers possess high porosity specific surface area, which provide necessary microenvironment for wound healing. Here in, Soluplus-soy protein isolate (Sol-SPI) containing mupirocin (Mp) were fabricated via electrospinning treatment. The exhibited water absorption capacities about 300.83 ± 29.72% vapor permeability values 821.8 49.12 g/m 2 day. Sol/SPI/Mp showed an in vitro degradability 33.73 3.55% after 5 days. ultimate tensile strength, elastic modulus, elongation measured as 3.61 0.29 MPa, 39.15 5.08 59.11 1.94%, respectively. Additionally, 85.90 6.02% Mp loaded was released days vitro, by applying Mp-loaded nanofibers, 93.06 5.40% 90.40 5.66% S. aureus E. coli bacteria killed, Human keratinocyte cells (HaCat) demonstrated notable biocompatibility with prepared nanofibers. Furthermore, compare to other groups, Sol-SPI-Mp caused fastest re-epithelialization healing a rat model. findings this study present novel nanofiber-based dressing that accelerates severe skin wounds risk infection.

Язык: Английский

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Probiotic active gel promotes diabetic wound healing through continuous local glucose consumption and antioxidant

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Янв. 30, 2025

Язык: Английский

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Antibacterial and osteogenic properties of chitosan-polyethylene glycol nanofibre-coated 3D printed scaffold with vancomycin and insulin-like growth factor-1 release for bone repair

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 139883 - 139883

Опубликована: Янв. 1, 2025

Язык: Английский

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Icariside II enhances crania defect repair through synergistic angiogenesis and osteogenesis

Tissue and Cell, Год журнала: 2025, Номер 95, С. 102833 - 102833

Опубликована: Март 7, 2025

Язык: Английский

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Metal-based nanomedicine systems for the diagnosis and treatment of colorectal cancer: Current advances and future perspectives

Materials Today Chemistry, Год журнала: 2025, Номер 45, С. 102702 - 102702

Опубликована: Апрель 1, 2025

Язык: Английский

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Injectable myocardium-derived hydrogels with SDF-1α releasing for cardiac repair

Biomaterials Advances, Год журнала: 2025, Номер unknown, С. 214203 - 214203

Опубликована: Янв. 1, 2025

Язык: Английский

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Doxycycline-integrated silk fibroin hydrogel: preparation, characterizations, and antimicrobial assessment for biomedical applications

BMC Oral Health, Год журнала: 2025, Номер 25(1)

Опубликована: Фев. 1, 2025

Tooth extraction, a common dental procedure, is often accompanied by pain, trismus, and swelling due to alveolitis caused oral bacteria. Doxycycline prescribed alleviate infection improve socket healing, but its immediate absorption in the bloodstream makes treatment less effective at sites. This emphasizes importance of drug delivery system gradually slow release wound site increase bioavailability make over time. Silk fibroin (SF) - doxycycline hyclate (DH) hydrogel was developed subsequently characterized for gelation kinetics, swelling, stress-strain analysis, morphology using scanning electron microscopy, interaction between SF DH Fourier transform infrared (FT-IR) spectroscopy, profile, antibacterial efficacy, biocompatibility studies. The results indicated that SF-DH maintained structural integrity, tolerated stress strain, featured interconnected pores, confirming integration within matrix. formed 8 h with pore size range 20–150 μm 90.72 kPa Young's modulus. profile showed increased up 2 h, followed sustained till h. zone inhibition smaller hydrogels compared both Staphylococcus aureus Streptococcus mutans. Furthermore, MC3T3-E1 cells 90% viability hydrogel. findings suggest sufficient mechanical strength, size, antimicrobial activity, biocompatibility. Further vivo clinical tests are required prove efficacy healing.

Язык: Английский

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Incorporation of forsterite nanoparticles in a 3D printed polylactic acid/polyvinylpyrrolidone scaffold for bone tissue regeneration applications

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 141046 - 141046

Опубликована: Фев. 1, 2025

Язык: Английский

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Multifunctional hydrogel targeting senescence to accelerate diabetic wound healing through promoting angiogenesis

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Март 6, 2025

Diabetic wound healing remains a significant clinical challenge because of hyperglycaemia-induced cellular senescence, impaired angiogenesis, and chronic inflammation. To address these issues, we developed multifunctional hydrogel (GelMA/PNS/Alg@IGF-1) that integrates gelatine methacryloyl (GelMA), Panax notoginseng saponins (PNS), sodium alginate microspheres encapsulating insulin-like growth factor-1 (IGF-1). This was engineered to achieve gradient sustained release bioactive agents target senescence promote vascular repair. In vitro studies demonstrated the significantly reduced oxidative stress, suppressed markers senescence-associated secretory phenotypes, restored endothelial cell function under high-glucose conditions by inhibiting NF-κB pathway activation. Transcriptomic analysis revealed modulation pathways linked inflammation, apoptosis, angiogenesis. accelerated diabetic closure in rat model vivo enhanced collagen deposition, granulation tissue formation, neovascularization. Furthermore, mitigated stress promoted remodelling. The synergistic effects PNS IGF-1 within established pro-regenerative microenvironment both pathological ageing dysfunction. These findings highlight GelMA/PNS/Alg@IGF-1 as promising therapeutic platform for management, this material offers dual anti-senescence proangiogenic efficacy overcome complexities healing.

Язык: Английский

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