Polymer‐Mediated Delivery of Amphotericin B for Fungal Infections

Macromolecular Rapid Communications, Год журнала: 2025, Номер unknown

Опубликована: Март 19, 2025

Abstract Invasive fungal infections have been an increasingly global issue with high mortality. Amphotericin B (AmB), as the “gold standard” antifungal drug, has broad‐spectrum activity and low clinical resistance. Therefore, AmB is most commonly used polyene antibiotic for treatment of invasive infections. However, serious side effects well bioavailability strongly restrict its applications. Polymer, diversified molecular design, widely in drug delivery form polymeric prodrugs, nanoparticles, hydrogels, etc. polymers hold great promise treating This review summarizes recent advances polymer‐based systems infections, including polymer‐AmB conjugates, nanotechnology‐based systems, microneedles. Taking advantage strategies, special attention paid to reducing improving safe effective therapy. Finally, limitations possible future directions are discussed.

Язык: Английский

Continuous-flow microfluidic process to produce amphotericin B-loaded polymeric nanoparticles for cutaneous leishmaniasis treatment

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106880 - 106880

Опубликована: Апрель 1, 2025

Язык: Английский