Adipose Mesenchymal Stem Cell‐Derived Exosomes Versus Platelet‐Rich Plasma Treatment for Photoaged Facial Skin: An Investigator‐Blinded, Split‐Face, Non‐Inferiority Trial
Journal of Cosmetic Dermatology,
Год журнала:
2025,
Номер
24(5)
Опубликована: Май 1, 2025
ABSTRACT
Background
Exosomes,
an
emerging
treatment
of
interest
to
aesthetic
dermatology,
have
therapeutic
applications
in
skin
rejuvenation,
alopecia,
atopic
dermatitis,
acne
scarring,
and
wound
healing.
Platelet‐rich
plasma
has
been
widely
utilized
for
the
same
indications,
among
others.
Currently,
there
are
no
trials
comparing
two
regenerative
modalities
dermatology.
Aims
To
compare
efficacy
safety
adipose
mesenchymal
stem
cell‐derived
(ASC)
exosomes
versus
platelet‐rich
photoaged
facial
skin.
Methods
An
investigator‐blinded,
split‐face
trial
was
conducted.
Participants
with
mild
moderate
photoaging
underwent
three
radiofrequency
microneedling
treatments
PRP
topical
each
applied
one
half
face.
Results
Both
equally
improved
wrinkling,
dyschromia,
erythema,
texture,
overall
appearance.
Histological
analysis
confirmed
increased
collagen
I
glycosaminoglycans,
without
significant
differences
between
arms.
Conclusion
ASC
a
promising
PRP‐alternative
that
may
be
attractive
needle‐averse
patients
can
hasten
office
visit
duration,
as
phlebotomy
centrifugation
not
required.
Язык: Английский
Therapeutic Potential of Extracellular Vesicles (Exosomes) Derived From Platelet‐Rich Plasma: A Literature Review
Journal of Cosmetic Dermatology,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 1, 2024
ABSTRACT
Background
There
are
exciting
advances
in
the
field
of
exosomes
research
as
a
potential
regenerative
therapy.
Platelet‐rich
plasma
represents
an
abundant
source
exosomes.
Aim
To
present
evidence
on
use
platelet‐rich
plasma‐derived
dermatology
and
discuss
current
technical
limitations.
Methods
A
literature
search
was
conducted
using
Embase
(Ovid),
Web
Science,
ClinicalTrials.gov
June
2024.
Results
contain
myriad
growth
factors,
genetic
materials,
lipids
that
mediate
paracrine
signaling.
Several
preclinical
studies
have
demonstrated
their
wound
healing.
This
includes
faster
contraction
diabetic
animal
models,
well
enhanced
angiogenesis,
increased
cell
proliferation
migration,
protection
against
hyperglycemic
conditions
vitro.
case
study
reported
topical
platelet‐derived
exosome
product
tried
successfully
patient
with
persistent
scalp
wounds.
In
contrast,
there
is
scarce
information
hair
skin
rejuvenation.
Isolation
techniques,
activation
methods,
methods
delivery
not
been
optimized,
which
warrants
further
research.
Novel
such
hydrogel‐based
preparations,
may
enable
application
Conclusion
Exosomes
derived
from
therapeutic
potential.
More
needed
to
standardize
its
use.
Язык: Английский
Ligand-based Exosome Affinity Purification (LEAP) Column Chromatography: A Tool for Clinical Applications
West Kazakhstan Medical Journal,
Год журнала:
2024,
Номер
66(4), С. 365 - 372
Опубликована: Дек. 20, 2024
Exosomes
are
nano-sized
extracellular
vesicles
that
play
essential
roles
in
intercellular
communication,
carrying
biomolecules
such
as
proteins,
lipids,
and
RNAs
can
influence
physiological
pathological
processes.
The
isolation
of
pure
exosomes
is
critical
for
both
basic
research
clinical
applications,
including
diagnostics
therapeutics.
Traditional
exosome
techniques,
ultracentrifugation,
lack
specificity
may
yield
impure
samples,
making
the
need
advanced
techniques
evident.
Ligand-based
affinity
purification
(LEAP)
column
chromatography
has
emerged
a
novel
method
utilizes
specific
ligands
targeting
surface
markers,
providing
highly
specific,
gentle,
scalable
approach
to
isolation.
This
mini
review
explores
LEAP
chromatography’s
mechanism,
benefits,
potential
emphasizing
its
g.rowing
importance
exosome-based
therapies.
Язык: Английский