The Microbiota-Gut-Brain Axis

Physiological Reviews, Год журнала: 2019, Номер 99(4), С. 1877 - 2013

Опубликована: Авг. 28, 2019

The importance of the gut-brain axis in maintaining homeostasis has long been appreciated. However, past 15 yr have seen emergence microbiota (the trillions microorganisms within and on our bodies) as one key regulators function led to appreciation a distinct microbiota-gut-brain axis. This is gaining ever more traction fields investigating biological physiological basis psychiatric, neurodevelopmental, age-related, neurodegenerative disorders. brain communicate with each other via various routes including immune system, tryptophan metabolism, vagus nerve enteric nervous involving microbial metabolites such short-chain fatty acids, branched chain amino peptidoglycans. Many factors can influence composition early life, infection, mode birth delivery, use antibiotic medications, nature nutritional provision, environmental stressors, host genetics. At extreme diversity diminishes aging. Stress, particular, significantly impact at all stages life. Much recent work implicated gut many conditions autism, anxiety, obesity, schizophrenia, Parkinson’s disease, Alzheimer’s disease. Animal models paramount linking regulation fundamental neural processes, neurogenesis myelination, microbiome activation microglia. Moreover, translational human studies are ongoing will greatly enhance field. Future focus understanding mechanisms underlying attempt elucidate microbial-based intervention therapeutic strategies for neuropsychiatric

Язык: Английский

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Occurrence, fate, and risk assessment of typical tetracycline antibiotics in the aquatic environment: A review

The Science of The Total Environment, Год журнала: 2020, Номер 753, С. 141975 - 141975

Опубликована: Авг. 29, 2020

Язык: Английский

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Insights into the Fate and Removal of Antibiotics in Engineered Biological Treatment Systems: A Critical Review

Environmental Science & Technology, Год журнала: 2019, Номер 53(13), С. 7234 - 7264

Опубликована: Июнь 3, 2019

Antibiotics, the most frequently prescribed drugs of modern medicine, are extensively used for both human and veterinary applications. Antibiotics from different wastewater sources (e.g., municipal, hospitals, animal production, pharmaceutical industries) ultimately discharged into treatment plants. Sorption biodegradation two major removal pathways antibiotics during biological processes. This review provides fundamental insights sorption mechanisms classes with diverse physical–chemical attributes. Important factors affecting behavior also highlighted. Furthermore, this sheds light on critical role extracellular polymeric substances adsorption their in engineered systems. Despite advancements, systems only moderately effective (48–77%) antibiotics. In review, we systematically summarize various discussion efficiency, mechanisms, bioreactor operating conditions removal, recent innovative advancements. Besides, relevant background information including classification, properties, occurrence environment is briefly covered. aims to advance our understanding fate outlines future research directions.

Язык: Английский

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Effects of environmental pollutants on gut microbiota

Environmental Pollution, Год журнала: 2017, Номер 222, С. 1 - 9

Опубликована: Янв. 11, 2017

Язык: Английский

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The occurrence, distribution and degradation of antibiotics by ionizing radiation: An overview

The Science of The Total Environment, Год журнала: 2018, Номер 646, С. 1385 - 1397

Опубликована: Июль 31, 2018

Язык: Английский

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Antimicrobial pharmaceuticals in the aquatic environment - occurrence and environmental implications

European Journal of Pharmacology, Год журнала: 2019, Номер 866, С. 172813 - 172813

Опубликована: Ноя. 18, 2019

The environmental occurrence of antimicrobial pharmaceuticals and antibiotic resistant bacteria genes has become a global phenomenon multifaceted threat. Integrated actions many parties are needed to prevent further aggravation the problem. Well-directed require clear understanding problem, which can be ensured by frequent revaluation existing knowledge disseminating it among relevant audiences. goal this review paper is discuss abundance in aquatic environment context adverse effects caused directly these substances threat associated with antibiotics resistance phenomenon. Several classes (aminoglycosides, β-lactams, glycopeptides, macrolides, fluoroquinolones, sulfonamides trimethoprim, tetracyclines) have been selected illustrate their sources, abundance, degradation routes (transformation products) implications including ecotoxic effect spread within compartments wastewater treatment plants. Wastewater plants indeed main source responsible for prevalence factors environment, since predominantly not designed retain pharmaceuticals. In order limit impurities into better control recommended as well establishment stricter quality standards. Counteracting all above-mentioned threats requires undertake integrated activities based on cooperation professionals scientists from various fields science or industry, such sciences, medicine, veterinary, pharmacology, chemical engineering others.

Язык: Английский

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Kinetics of oxidative degradation/mineralization pathways of the antibiotic tetracycline by the novel heterogeneous electro-Fenton process with solid catalyst chalcopyrite

Applied Catalysis B Environment and Energy, Год журнала: 2017, Номер 209, С. 637 - 647

Опубликована: Март 11, 2017

Язык: Английский

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Insights into the fate and removal of antibiotics and antibiotic resistance genes using biological wastewater treatment technology

The Science of The Total Environment, Год журнала: 2021, Номер 776, С. 145906 - 145906

Опубликована: Фев. 18, 2021

Язык: Английский

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The Impact of Tetracycline Pollution on the Aquatic Environment and Removal Strategies

Antibiotics, Год журнала: 2023, Номер 12(3), С. 440 - 440

Опубликована: Фев. 23, 2023

Antibacterial drugs are among the most commonly used medications in world. Tetracycline is a widely antibiotic for human and animal therapy due to its broad-spectrum activity, high effectiveness, reasonable cost. The indications treatment with tetracycline include pneumonia, bone joint infections, infectious disorders of skin, sexually transmitted gastrointestinal infections. However, has become serious threat environment because overuse by humans veterinarians weak ability degrade. capable accumulating along food chain, causing toxicity microbial community, encouraging development spread resistance, creating threats drinking irrigation water, disrupting flora intestine. It essential address negative impact on environment, as it causes ecological imbalance. Ineffective wastewater systems main reasons increased concentrations aquatic sources. possible degrade breaking down into small molecules less harmful or nonhazardous effects. A range methods physical, chemical, biological degradation exists. review will discuss effects consumption describe available removal methods.

Язык: Английский

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Toxicological impacts of antibiotics on aquatic micro-organisms: A mini-review

International Journal of Hygiene and Environmental Health, Год журнала: 2017, Номер 220(3), С. 558 - 569

Опубликована: Фев. 23, 2017

Язык: Английский

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