
Research Square (Research Square), Год журнала: 2023, Номер unknown
Опубликована: Ноя. 7, 2023
Язык: Английский
Research Square (Research Square), Год журнала: 2023, Номер unknown
Опубликована: Ноя. 7, 2023
Язык: Английский
Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Янв. 10, 2024
Abstract Several studies have reported an increased risk of chronic kidney disease (CKD) outcomes after long-term exposure (more than 1 year) to particulate matter with aerodynamic diameter ≤ 2.5 µm (PM ). However, the conclusions remain inconsistent. Therefore, we conducted this meta-analysis examine association between PM and CKD outcomes. A literature search was in PubMed, Scopus, Cochrane Central Register Controlled trials, Embase for relevant published until August 10, 2023. The main were incidence prevalence as well end-stage (ESKD). random-effect model meta‐analyses used estimate each outcome among studies. Twenty two identified, including 14 cohort studies, 8 cross-sectional a total 7,967,388 participants. This revealed that 10 μg/m 3 increment significantly associated risks both [adjusted odds ratio (OR) 1.31 (95% confidence interval (CI) 1.24 1.40), adjusted OR CI 1.03 1.67), respectively]. In addition, relationship ESKD is suggestive but not conclusive (adjusted 1.16; 95% 1.00 1.36). had consistent across all subgroups adjustment variables. Our study observed CKD. more dedicated are required show causation warrants urgent action on mitigate global burden
Язык: Английский
Процитировано
9Environmental Geochemistry and Health, Год журнала: 2024, Номер 46(2)
Опубликована: Фев. 1, 2024
Язык: Английский
Процитировано
4Environmental Toxicology and Pharmacology, Год журнала: 2025, Номер unknown, С. 104712 - 104712
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Июль 22, 2024
Chronic kidney disease (CKD) is a major global public health issue and the leading cause of death in Thailand. This study investigated spatial–temporal association between PM2.5 its components (organic carbon, black dust, sulfate, sea salt) CKD mortality Thailand from 2012 to 2021. The Modern-Era Retrospective analysis for Research Application version 2 (MERRA-2), NASA atmospheric satellite model, was assessed temporal data concentration aerosol components. Spatial resources 77 provinces were integrated using Geographical Information System (GIS). Multivariate Poisson regression Bayesian inference analyses conducted explore effects on across provinces. Our included 718,686 CKD-related deaths, resulting rate 1107 cases per 100,000 population where highest Northeast region. average age deceased 72.43 ± 13.10 years, with males comprising 50.46% cases. Adjusting age, sex, underlying diseases, co-morbidities, complications, replacement therapy, density, income, each 1 µg/m3 increase PM2.5, organic carbon significantly associated increased Incidence ratios 1.04 (95% CI 1.03–1.04) 1.11 1.10–1.13) 1.24 1.22–1.25) 1.16 1.16–1.17) 1.05 1.04–1.05) carbon. These findings emphasize significant impact underscore need strategies reduce PM emissions manage co-morbidities effectively.
Язык: Английский
Процитировано
3Current Pollution Reports, Год журнала: 2024, Номер 11(1)
Опубликована: Окт. 9, 2024
Язык: Английский
Процитировано
2Journal of Biochemical and Molecular Toxicology, Год журнала: 2023, Номер 38(1)
Опубликована: Дек. 13, 2023
Abstract Although epidemiological studies have evaluated the association between ambient air pollution and chronic kidney disease (CKD), results remain mixed. To clarify nature of association, we conducted a comprehensive systematic review meta‐analysis to assess global relationship CKD. The Web Science, PubMed, Embase Cochrane Library databases systematically were searched for published up July 2023 included 32 that met specific criteria. random effects model was used derive overall risk estimates each pollutant. estimated odds ratio (ORs) CKD 1.42 (95% confidence interval [CI]: 1.31–1.54) 10 μg/m 3 increase in PM 2.5 ; 1.20 CI: 1.14–1.26) 1.07 1.05–1.09) NO 2 1.03 1.02–1.03) X 1.01–1.12) 1 ppb SO 1.00–1.05) 0.1 ppm CO. Subgroup analysis showed this effect varied by gender ratio, age, study design, exposure assessment method, income level. Furthermore, , had negative on even within World Health Organization‐recommended acceptable concentrations. Our further confirmed adverse These findings can contribute enhance awareness importance reducing among public health officials policymakers.
Язык: Английский
Процитировано
5The Science of The Total Environment, Год журнала: 2024, Номер 929, С. 172638 - 172638
Опубликована: Апрель 21, 2024
Язык: Английский
Процитировано
1JMIR Aging, Год журнала: 2024, Номер 7, С. e59818 - e59818
Опубликована: Окт. 28, 2024
Background China's rapidly aging population necessitates effective strategies for ensuring older adults' quality of life (QOL). While individual factors (IF) and family (FF) are known to influence QOL, existing research often examines these in isolation or focuses on specific subpopulations, overlooking potential interactions mediating pathways. Objective This study aims examine both direct indirect pathways connecting IF FF adults’ focusing the roles health risks (HR) care service demand (HSD). Methods uses structural equation modeling (SEM) analyze cross-sectional data from 8600 participants 2015 China Health Retirement Longitudinal Study (CHARLS), a nationally representative using multistage probability proportional size sampling method. Results Among participants, majority (5586/8502, 65.7%) were aged 60-70 years, with near-equal distribution males females at around 50%. The average PCS score was 76.77, while MCS averaged 59.70. Both (β=0.165, P<.001) (β=0.189, had positive effect QOL. Furthermore, effects (β=0.186, (β=0.211, through HR HSD also significant. In model, greater impact (β=0.841) than (β=0.639). However, after including 2 factors, HSD, (β=0.739) became consistent that (β=0.728). Subgroup analyses revealed QOL significant age group (β=0.151, but not those over 70 years old (β=0.122, P=.074). Comorbidity status significantly influenced pathway adults having more chronic diseases (β=0.363) showing compared fewer (β=0.358). Conclusions (education, per capita disposable income, endowment insurance) (satisfaction spouse children) directly people. Meanwhile, have equal role HSD. Recognizing interplay among is crucial targeted interventions enhance well-being China.
Язык: Английский
Процитировано
1Current Research in Toxicology, Год журнала: 2024, Номер 7, С. 100189 - 100189
Опубликована: Янв. 1, 2024
Exposure to fine particulate matter (PM2.5) has been associated with the development and progression of renal disease. Peroxisome proliferator-activated receptor gamma (PPARγ), a key transcription factor involved in inflammation as well lipid glucose metabolism, helps maintain integrity tubular epithelial cells. However, precise role PPARγ PM2.5-induced injury remains unclear. In this study, we investigated regulatory effects on ferroptotic stress epithelial–mesenchymal transition (EMT) (HK-2) We found that downregulation expression was correlated EMT PM2.5-exposed Pretreatment agonist 15d-PGJ2 protected cells from by reducing stress, whereas antagonist GW9662 promoted EMT. Furthermore, pretreatment ferrostatin-1 (Fer-1) significantly prevented expression. Notably, overexpression blocked E-cadherin GPX4 upregulation α-SMA This study highlights complex associations ferroptosis Our findings suggest activation confers protection against injury.
Язык: Английский
Процитировано
0Stochastic Environmental Research and Risk Assessment, Год журнала: 2024, Номер 38(10), С. 4027 - 4041
Опубликована: Авг. 6, 2024
Язык: Английский
Процитировано
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