Harnessing strategies for enhancing diabetic wound healing from the perspective of spatial inflammation patterns

Bioactive Materials, Год журнала: 2023, Номер 28, С. 243 - 254

Опубликована: Май 31, 2023

Diabetic wound is a great threat to patient's health and lives. The refractory diabetic shows spatial inflammation patterns, in which the early-wound pattern depicts deprived acute inflammatory response, long-term non-healing delineates an excessive persistent due delayed immune cell infiltration positive feedback loop. In this work, we give points some strategies normalize dysregulated process based on differences healing. First of all, inhibiting response avoid subsequent for early proposed. However, wounds are unperceptive trauma that makes patients miss best treatment time. Therefore, also introduce two wound. One strategy about changing chronic ones, aims rejuvenate M1 macrophages make spontaneous M2 polarization possible. To activate controllable proinflammatory western medicine delivers molecules while traditional Chinese develops "wound-pus promoting granulation tissue growth theory". Another solve seeking switches target M1/M2 transition directly. These investigations draw map enhancing healing from perspective patterns systematically.

Язык: Английский

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Advances in the Preparation of Nanofiber Dressings by Electrospinning for Promoting Diabetic Wound Healing

Biomolecules, Год журнала: 2022, Номер 12(12), С. 1727 - 1727

Опубликована: Ноя. 22, 2022

Chronic diabetic wounds are one of the main complications diabetes, manifested by persistent inflammation, decreased epithelialization motility, and impaired wound healing. This will not only lead to repeated hospitalization patients, but also bear expensive costs. In severe cases, it can amputation, sepsis or death. Electrospun nanofibers membranes have characteristics high porosity, specific surface area, easy functionalization structure, so they be used as a safe effective platform in treatment great application potential. article briefly reviewed pathogenesis chronic types dressings commonly used, then development electrospinning technology recent years advantages electrospun wounds. Finally, reports different nanofiber on summarized, method using multi-drug combination therapy is emphasized, which provides new ideas for

Язык: Английский

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Chinmedomics: a potent tool for the evaluation of traditional Chinese medicine efficacy and identification of its active components

Chinese Medicine, Год журнала: 2024, Номер 19(1)

Опубликована: Март 13, 2024

Abstract As an important part of medical science, Traditional Chinese Medicine (TCM) attracts much public attention due to its multi-target and multi-pathway characteristics in treating diseases. However, the limitations traditional research methods pose a dilemma for evaluation clinical efficacy, discovery active ingredients elucidation mechanism action. Therefore, innovative approaches that are line with TCM theory practice urgently needed. Chinmendomics, newly emerging strategy evaluating efficacy TCM, is proposed. This combines systems biology, serum pharmacochemistry bioinformatics evaluate holistic view by accurately identifying syndrome biomarkers monitoring their complex metabolic processes intervened finding agents associated course pharmacodynamic constructing bioinformatics-based correlation network model further reveal interaction between targets. In this article, we review recent progress Chinmedomics promote application modernisation internationalisation TCM.

Язык: Английский

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Multifunctional gold clusterzymes with distinct glucose depletion and macrophage reprogramming capability towards regulating the regeneration cascade

Chemical Engineering Journal, Год журнала: 2024, Номер unknown, С. 149068 - 149068

Опубликована: Янв. 1, 2024

Язык: Английский

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A Multifunctional Herb‐Derived Glycopeptide Hydrogel for Chronic Wound Healing

Small, Год журнала: 2024, Номер unknown

Опубликована: Апрель 30, 2024

Chronic wounds constitute an increasingly prevalent global healthcare issue, characterized by recurring bacterial infections, pronounced oxidative stress, compromised functionality of immune cells, unrelenting inflammatory reactions, and deficits in angiogenesis. In response to these multifaceted challenges, the study introduced a stimulus-responsive glycopeptide hydrogel constructed oxidized Bletilla striata polysaccharide (OBSP), gallic acid-grafted ε-Polylysine (PLY-GA), paeoniflorin-loaded micelles (MIC@Pae), called OBPG&MP. The emulates structure glycoprotein fibers extracellular matrix (ECM), exhibiting exceptional injectability, self-healing, biocompatibility. It adapts responsively microenvironment chronic wounds, sequentially releasing therapeutic agents eradicate infection, neutralize reactive oxygen species (ROS), modulate macrophage polarization, suppress inflammation, encourage vascular regeneration ECM remodeling, playing critical role across inflammatory, proliferative, remodeling phases wound healing. Both vitro vivo studies confirmed efficacy OBPG&MP regulating enhancing skin tissue. This research supports vast potential for herb-derived multifunctional hydrogels tissue engineering regenerative medicine.

Язык: Английский

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A dihydromyricetin-loaded phellinus igniarius polysaccharide/l-arginine modified chitosan-based hydrogel for promoting wound recovery in diabetic mice via JNK and TGF-β/Smad signaling pathway

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 259, С. 129124 - 129124

Опубликована: Янв. 3, 2024

Язык: Английский

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Research on traditional Chinese medicine as an effective drug for promoting wound healing

Journal of Ethnopharmacology, Год журнала: 2024, Номер 332, С. 118358 - 118358

Опубликована: Май 17, 2024

Язык: Английский

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High Glucose‐Induced Senescent Fibroblasts‐Derived Exosomal miR‐497 Inhibits Wound Healing by Regulating Endothelial Cellular Autophagy via ATG13

Analytical Cellular Pathology, Год журнала: 2025, Номер 2025(1)

Опубликована: Янв. 1, 2025

Язык: Английский

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The role of mesenchymal stem cell-derived EVs in diabetic wound healing

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Фев. 28, 2023

Diabetic foot is one of the most common complications diabetes, requiring repeated surgical interventions and leading to amputation. In absence effective drugs, new treatments need be explored. Previous studies have found that stem cell transplantation can promote healing chronic diabetic wounds. However, safety issues limited clinical application this technique. Recently, performance mesenchymal cells after has been increasingly attributed their production exocrine functional derivatives such as extracellular vesicles (EVs), cytokines, cell-conditioned media. EVs contain a variety cellular molecules, including RNA, DNA proteins, which facilitate exchange information between cells. several advantages over parental cells, high profile, no immune response, fewer ethical concerns, reduced likelihood embolism formation carcinogenesis. paper, we summarize current knowledge cell-derived in accelerating wound healing, well potential clinic applications.

Язык: Английский

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Metabolic Changes of Active Components of Important Medicinal Plants on the basis of Traditional Chinese Medicine under Different Environmental Stresses

Current Organic Chemistry, Год журнала: 2023, Номер 27(9), С. 782 - 806

Опубликована: Май 1, 2023

Abstract: Traditional Chinese medicine is an ancient system of wellness and health that has been used in almost all countries the world, specially Asia for thousands years. : The growth, development, final yield chemical compounds medicinal plants can be negatively influenced by different kinds biotic abiotic stresses. Abiotic stress signals are (Mineral salts, heavy metal, aerosols, gaseous toxins, pesticides, pollutants), salinity (salt), temperature (Heat, cold), radiation (Ionisation radiation, light UV), water (Flooding, drought) mechanical (Submergence, wind, soil movement). Relevant literature obtained using keywords “Traditional Medicine”, “Abiotic Stress”, “Biotic “Ginseng”, “Ginger”, “Goji berry”, “Astragalus”, “Ginkgo”, “Artemisia annua L.”, “LC-MS”, “GC-MS”, “NMR” scientific information, namely “Web Science”, “PubMed”, “SciFinder”, “Elsevier”. Some plants’ secondary metabolites under growth conditions Camptothecin (Camptotheca acuminata), Capsaicin (Capsicum sp.), Rosmarinic acid (Salvia miltiorrhiza), Codeine (Papaver somniferum), Resveratrol (Grapes, groundnut), Artemisinin (Artemesia annua), Allicin (Allium sativum), Rohitukine (Dysoxylum binectariferum), Stevioside (Stevia rebaudiana), Andrographolide (Andrographis paniculata), Saikosaponins (Bupleurum chinense), Sennosides (Cassia augustifolia), Rutin (Dimorphandra mollis), Valepotriates (Valeria species), Indole alkaloids (Catharanthus roseous), Furanocoumarins (Bituminaria bituminosa). aim this article a survey active metabolic changes some most important traditional (TCM) both Future research needed to evaluate effects stresses on medicine, more surveys roles LC-MS, GC-MS NMR techniques better understanding components plants.

Язык: Английский

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