Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160379 - 160379
Опубликована: Фев. 1, 2025
Язык: Английский
Chemical Engineering Journal, Год журнала: 2024, Номер 481, С. 148768 - 148768
Опубликована: Янв. 18, 2024
Язык: Английский
Процитировано
26
Biomedicines, Год журнала: 2024, Номер 12(4), С. 743 - 743
Опубликована: Март 27, 2024
Mesenchymal stem cells (MSCs) have been recognized as a cell therapy with the potential to promote skin healing. MSCs, their multipotent differentiation ability, can generate various related wound healing, such dermal fibroblasts (DFs), endothelial cells, and keratinocytes. In addition, MSCs neovascularization, cellular regeneration, tissue healing through mechanisms including paracrine autocrine signaling. Due these characteristics, extensively studied in context of burn chronic repair. Furthermore, during investigation unique roles aging scarless also discovered. this review, we summarize by which discuss recent findings from preclinical clinical studies. We explore strategies enhance therapeutic effects MSCs. Moreover, emerging trend combining engineering techniques, leveraging advantages materials, biodegradable scaffolds hydrogels, repair capacity Additionally, highlight using characteristics cell-free therapies future direction cell-based treatments, further demonstrating regenerative aesthetic applications regeneration.
Язык: Английский
Процитировано
22
Journal of Controlled Release, Год журнала: 2024, Номер 368, С. 518 - 532
Опубликована: Март 12, 2024
Язык: Английский
Процитировано
17
ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(26), С. 33205 - 33222
Опубликована: Июнь 25, 2024
In diabetic patients with skin injuries, bacterial proliferation, accumulation of reactive oxygen species (ROS) in the tissues, and impaired angiogenesis make wound healing difficult. Therefore, eliminating bacteria, removing ROS, promoting are necessary for treating acute wounds. this study, benefiting from ability polyphenols to form a metal-phenolic network (MPN) metal ions, TA-Eu MPN nanoparticles (TM NPs) were synthesized. The prepared photothermal agent CuS NPs TM then loaded onto supporting base needle tips PVA/HA (PH) microneedles, respectively, obtain PH/CuS/TM microneedles. Antibacterial experiments showed that microneedles could remove bacteria by effect. vitro effectively scavenge inhibit macrophage polarization M1 type, induce M2 type as well have promote vascular endothelial cell migration angiogenesis. Furthermore, vivo accelerated inhibiting pro-inflammatory cytokines rat model. efficient antibacterial, ROS scavenging, anti-inflammatory, immunomodulatory, angiogenic abilities hold promise dressings
Язык: Английский
Процитировано
15
Materials Today Bio, Год журнала: 2024, Номер 26, С. 101093 - 101093
Опубликована: Май 18, 2024
The incidence of chronic wound healing is promoted by the growing trend elderly population, obesity, and type II diabetes. Although numerous dressings have been studied over years, it still challenging for many to perfectly adapt process due dynamic complicated microenvironment. Aiming at an optimal reproduction physiological environment, multifunctional electrospinning nanofibrous membranes (ENMs) emerged as a promising platform treatment owing their resemblance extracellular matrix (ECM), adjustable preparation processes, porousness, good conformability site. Moreover, profiting from booming development human-machine interaction artificial intelligence, next generation intelligent (iENMs) based dressing substrates that could realize real-time monitoring proceeding individual-based therapy has evoked surge interest. In this regard, general wound-related biomarkers are overviewed firstly representative iENMs stimuli-responsive materials briefly summarized. Subsequently, emergent applications highlighted. Finally, opportunities challenges next-generation well translating into clinical practice evaluated.
Язык: Английский
Процитировано
13
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Авг. 14, 2024
Macrophages play a pivotal role in the healing of diabetic ulcers. The sustained elevation glucose levels damages insulin signaling pathway macrophages, leading to dysfunctional macrophages that struggle transition from pro-inflammatory (M1) reparative (M2) states. Therefore, modulating macrophage inflammatory responses via holds promise for ulcer treatment. Additionally, presence biofilm impedes drug penetration, and resulting immunosuppressive microenvironment exacerbates persistent infiltration M1 macrophages. we designed an array dissolvable microneedle (denoted as NPF@MN) loaded with self-assembled nanoparticles could deliver NPF nanoparticles, acid-sensitive NPF-releasing Protocatechualdehyde (PA) hypoglycemic insulin-like effects, regulating polarization anti-inflammatory M2 phenotype. this study extensively examined mechanism by which NPF@MN accelerates ulcers through activation pathway. Through RNA-seq GSEA analysis, identified reduction expression pathway-related factors such IR, IRS-1, IRS-2, SHC. Our work presents innovative therapeutic approach targeting underscores its translational potential clinical management.
Язык: Английский
Процитировано
13
Advanced Healthcare Materials, Год журнала: 2024, Номер 13(16)
Опубликована: Март 12, 2024
Abstract The management of diabetic wounds (DWs) continues to pose a significant challenge in the field medicine. DWs are primarily prevented from healing due damage macrophage efferocytosis and fibroblast dysfunction. Consequently, treatment strategy that involves both immunoregulation promotion extracellular matrix (ECM) formation holds promise for DWs. Nevertheless, existing methods necessitate complex interventions associated with increased costs, example, use cytokines cell therapy, which have limited effectiveness. In this study, new type ruthenium (IV) oxide nanoparticles (RNPs)‐laden hybrid hydrogel dressing double network Pluronic F127 F68 has been developed. Notably, demonstrates remarkable thermosensitivity, injectability, immunoregulatory characteristics, capability. RNPs effectively regulate fibroblasts macrophages cascade manner, stimulating differentiation while synergistically enhancing macrophage. character aids restoring intrinsic stability immune microenvironment wound facilitates essential remodeling ECM. This therefore offers novel approach treating through intercellular communication.
Язык: Английский
Процитировано
11
Carbohydrate Polymers, Год журнала: 2024, Номер 337, С. 122146 - 122146
Опубликована: Апрель 16, 2024
Язык: Английский
Процитировано
11
Biomaterials Research, Год журнала: 2024, Номер 28
Опубликована: Янв. 1, 2024
Random flap grafting is a routine procedure used in plastic and reconstructive surgery to repair reconstruct large tissue defects. Flap necrosis primarily caused by ischemia–reperfusion injury inadequate blood supply the distal flap. Ischemia–reperfusion leads production of excessive reactive oxygen species, creating pathological microenvironment that impairs cellular function angiogenesis. In this study, we developed remodeling self-healing hydrogel [laminarin–chitosan-based hydrogel-loaded extracellular vesicles ceria nanozymes (LCH@EVs&CNZs)] improve synergistically promote regeneration survival. The natural (LCH) was created oxidation laminarin carboxymethylated chitosan via Schiff base reaction. We loaded with CNZs EVs. are class nanomaterials enzymatic activity known for their strong scavenging capacity thus alleviating oxidative stress. EVs cell-secreted vesicular structures containing thousands bioactive substances can cell proliferation, migration, differentiation, constructed LCH@EVs&CNZs demonstrated robust excess thereby conferring protection stress environments. Moreover, these constructs notably enhance migration Our results demonstrate effectively remodel skin marked This approach introduces new therapeutic strategy combining microenvironmental EV therapy, which holds promise promoting
Язык: Английский
Процитировано
9
Nano Today, Год журнала: 2024, Номер 56, С. 102235 - 102235
Опубликована: Март 22, 2024
Recurrent inflammation, intense bacterial infections, and inadequate blood vessel growth make diabetic wounds non-healing. Under pathological environment, cellular functions are also inhibited. In this paper, we developed a novel in situ injectable photo-crosslinking hydrogel embedded with heterojunction Ag@ZnO nanoparticles (NPs) which exhibit dual-channel synergistic ion release reactive oxygen species (ROS) production for anti-bacteria cutaneous regeneration. This platform can be introduced onto any irregular wound form gelation 395 nm UV light irradiation only 5 s. After being affixed to the wound, Ag+ Zn2+ released as first interaction healing. Foremost, formed on interface of Ag ZnO has ability capture water instigate generation "ROS storm", disrupt structural integrity bacteria, trigger leakage cytoplasmic content, enhance angiogenesis by activating VEGF CD31 expression, stimulate steps The continuous Ag+, storm" collaboratively drive deactivation, suppress promote proliferation, collagen deposition angiogenesis. These effects significantly accelerate chronic Therefore, such might provide promising new insight treatment.
Язык: Английский
Процитировано
9