Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics

Genes & Diseases, Год журнала: 2022, Номер 10(4), С. 1367 - 1401

Опубликована: Март 18, 2022

Cancer is an abnormal state of cells where they undergo uncontrolled proliferation and produce aggressive malignancies that causes millions deaths every year. With the new understanding molecular mechanism(s) disease progression, our knowledge about snowballing, leading to evolution many therapeutic regimes their successive trials. In past few decades, various combinations therapies have been proposed are presently employed in treatment diverse cancers. Targeted drug therapy, immunotherapy, personalized medicines now largely being employed, which were not common a years back. The field cancer discoveries therapeutics evolving fast as type-specific biomarkers progressively identified several types cancers nowadays undergoing systematic therapies, extending patients' disease-free survival thereafter. Although growing evidence shows targeted approach could be future medicine, chemotherapy remains opted option despite its known side effects on patient's physical psychological health. Chemotherapeutic agents/pharmaceuticals served great purpose over decades remained frontline choice for advanced-stage surgery and/or radiation therapy cannot prescribed due specific reasons. present report succinctly reviews existing contemporary advancements assesses status enrolled drugs/pharmaceuticals; it also comprehensively discusses emerging role specific/targeted strategies achieve better clinical success/survival rate patients.

Язык: Английский

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Natural Antioxidants from Plant Extracts in Skincare Cosmetics: Recent Applications, Challenges and Perspectives

Cosmetics, Год журнала: 2021, Номер 8(4), С. 106 - 106

Опубликована: Ноя. 10, 2021

In recent years, interest in the health effects of natural antioxidants has increased due to their safety and applicability cosmetic formulation. Nevertheless, efficacy vivo is less documented than prooxidant properties vivo. Plant extracts rich vitamins, flavonoids, phenolic compounds can induce oxidative damage by reacting with various biomolecules while also providing antioxidant properties. Because biological activities differ, effectiveness for slowing aging process remains unclear. This review article focuses on use skincare possible mechanisms underlying desired effect, along applications formulation limitations.

Язык: Английский

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Anticancer Applications and Pharmacological Properties of Piperidine and Piperine: A Comprehensive Review on Molecular Mechanisms and Therapeutic Perspectives

Frontiers in Pharmacology, Год журнала: 2022, Номер 12

Опубликована: Янв. 7, 2022

Piperine and piperidine are the two major alkaloids extracted from black pepper ( Piper nigrum ); is a heterocyclic moiety that has molecular formula (CH 2 ) 5 NH. Over years, many therapeutic properties including anticancer potential of these compounds have been observed. against cancers such as breast cancer, ovarian gastric gliomal lung oral squamous, chronic pancreatitis, prostate rectal cervical leukemia. Whereas, acts clinical agent cancers, colon when treated alone or in combination with some novel drugs. Several crucial signalling pathways essential for establishment STAT-3, NF-κB, PI3k/Aκt, JNK/p38-MAPK, TGF-ß/SMAD, Smac/DIABLO, p-IκB etc., regulated by phytochemicals. Both phytochemicals lead to inhibition cell migration help cycle arrest inhibit survivability cancer cells. The current review highlights pharmaceutical relevance both piperine different types cancers.

Язык: Английский

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Betelvine (Piper betleL.): A comprehensive insight into its ethnopharmacology, phytochemistry, and pharmacological, biomedical and therapeutic attributes

Journal of Cellular and Molecular Medicine, Год журнала: 2022, Номер 26(11), С. 3083 - 3119

Опубликована: Май 2, 2022

Piper betle L. (synonym: betel Blanco), or vine, an economically and medicinally important cash crop, belongs to the family Piperaceae, often known as green gold. The plant can be found all over world is cultivatedprimarily in South East Asian countries for its beautiful glossy heart-shaped leaves, which are chewed consumed betelquidand widely used Chinese Indian folk medicine, carminative, stimulant,astringent, against parasitic worms, conjunctivitis, rheumatism, wound, etc., andis also religious purposes. Hydroxychavicol most bioactive compound among wide range of phytoconstituents essential oil extracts. pharmacological attributes P. antiproliferation, anticancer, neuropharmacological, analgesic, antioxidant, antiulcerogenic, hepatoprotective, antifertility, antibacterial, antifungal many more. Immense attention has been paid nanoformulations their applications. application did not show cytotoxicity preclinical experiments, suggesting that it could serve a promising therapeutic candidate different diseases. present review comprehensively summarizes botanical description, geographical distribution, economic value cultivation, ethnobotanical uses, properties with insights toxicological, clinical efficacy, safety betle. findings suggest represents orally active safe natural agent exhibits great potential managing various human medical conditions. However, further research needed elucidate underlying molecular mechanisms action, aspects, structure-activity relationships, bioavailability synergistic interactions other drugs.

Язык: Английский

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Why traditional herbal medicine promotes wound healing: Research from immune response, wound microbiome to controlled delivery

Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 195, С. 114764 - 114764

Опубликована: Фев. 23, 2023

Язык: Английский

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Scutellarein alleviates chronic obstructive pulmonary disease through inhibition of ferroptosis by chelating iron and interacting with arachidonate 15‐lipoxygenase

Phytotherapy Research, Год журнала: 2023, Номер 37(10), С. 4587 - 4606

Опубликована: Июнь 24, 2023

Abstract Ferroptosis, an iron‐dependent cell death characterized by lethal lipid peroxidation, is involved in chronic obstructive pulmonary disease (COPD) pathogenesis. Therefore, ferroptosis inhibition represents attractive strategy for COPD therapy. Herein, we identified natural flavonoid scutellarein as a potent inhibitor the first time, and its underlying mechanisms of COPD. In vitro, anti‐ferroptotic activity was investigated through CCK8, real‐time quantitative polymerase chain reaction (RT‐qPCR), Western blotting, flow cytometry, transmission electron microscope (TEM). vivo, induced lipopolysaccharide (LPS)/cigarette smoke (CS) assessed changes histopathological, inflammatory, ferroptotic markers. The were RNA‐sequencing (RNA‐seq), electrospray ionization mass spectra (ESI‐MS), local surface plasmon resonance (LSPR), drug affinity responsive target stability (DARTS), cellular thermal shift assay (CETSA), molecular dynamics. Our results showed that significantly inhibited Ras‐selective small molecule (RSL)‐3‐induced mitochondria injury BEAS‐2B cells, ameliorated LPS/CS‐induced mice. Furthermore, also repressed RSL‐3‐ or GPX4 down‐regulation, overactivation Nrf2/HO‐1 JNK/p38 pathways. Mechanistically, Fe 2+ elevation directly chelating . Moreover, bound to peroxidizing enzyme arachidonate 15‐lipoxygenase (ALOX15), which resulted unstable state catalysis‐related cluster. Additionally, ALOX15 overexpression partially abolished scutellarein‐mediated activity. findings revealed alleviated inhibiting via interacting with ALOX15, highlighted candidate treatment other ferroptosis‐related diseases.

Язык: Английский

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Cumin (Cuminum cyminum L.) seeds accelerates wound healing in rats: Possible molecular mechanisms

Skin Research and Technology, Год журнала: 2024, Номер 30(5)

Опубликована: Май 1, 2024

Abstract Wound healing is a complex, intricate, and dynamic process that requires effective therapeutic management. The current study evaluates the wound potentials of methanolic extract Cuminum cyminum L. seeds (CCS) in rats. Sprague Dawley (24) rats were distributed into four cages, wounds produced on back neck, received two daily topical treatments for 14 days: A, normal saline; B, wounded treated with intrasite gel; C D, 0.2 mL 250 500 mg/kg CCS, respectively. After that, area closure percentage evaluated, tissues dissected histopathological, immunohistochemical, biochemical examinations. Acute toxicity trials CCS showed absence any physiological changes or mortality application caused significant reduction size statistically elevated contraction than those vehicle treatment up‐regulation collagen fiber, fibroblasts, fewer inflammatory cells (inflammation) granulation tissues. TGF‐β1 (angiogenetic factor) was significantly more expressed CCS‐treated comparison to saline‐treated rats; therefore, fibroblasts transformed myofibroblasts (angiogenesis). remarkable antioxidant (higher SOD CAT enzymes) decreased MDA (lipid peroxidation) levels their tissue homogenates. Hydroxyproline amino acid (collagen) up‐regulated by treatment, which commonly related faster area. outcomes suggest as viable new source pharmaceuticals treatment.

Язык: Английский

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Utilizing neem wood waste as a natural dye in the development of bio-based functionalized colored jute fabric

Sustainable Chemistry and Pharmacy, Год журнала: 2024, Номер 38, С. 101489 - 101489

Опубликована: Фев. 20, 2024

Язык: Английский

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Dioscin: A review on pharmacological properties and therapeutic values

BioFactors, Год журнала: 2021, Номер 48(1), С. 22 - 55

Опубликована: Дек. 16, 2021

Abstract Dioscin has gained immense popularity as a natural, bioactive steroid saponin, which offers numerous medical benefits. The growing global incidence of disease‐associated morbidity and mortality continues to compromise human health, facilitating an increasingly urgent need for nontoxic, noninvasive, efficient treatment alternatives. Natural compounds can contribute vastly this field. Over recent years, studies have demonstrated the remarkable protective actions dioscin against variety malignancies, metabolic disorders, organ injuries, viral/fungal infections. successful usage phytocompound been widely seen in procedures under traditional Chinese medicine, it is becoming progressively prevalent worldwide. This review provides insight into wide spectrum pharmacological activities dioscin, reported compiled literature. various novel approaches applications also verify advantages exhibited by plant extracts commercially available drugs, highlighting potential phytochemical agents like be further incorporated clinical practice.

Язык: Английский

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Synergistic effect of Aloe vera flower and Aloe gel on cutaneous wound healing targeting MFAP4 and its associated signaling pathway: In-vitro study

Journal of Ethnopharmacology, Год журнала: 2022, Номер 290, С. 115096 - 115096

Опубликована: Фев. 17, 2022

Aloe vera (L.) Burm. f. (Liliaceae family) is a well-known traditional medicinal plant, that has been used to treat variety of illnesses, for decades ranging from cancer skin disorders including wounds. It included in the and herbal healthcare systems many cultures around world, as well pharmacopeia different countries. Several vitro vivo studies have also confirmed its potential antioxidant, anti-inflammatory, wound-healing activities, etc. consistency historical uses. However, most date are based on A. gel latex effects. Very few focused flower, rarely with effects cutaneous wound healing molecular mechanism.To best our knowledge, this first study report synergistic effect flower (AVF) (PAG) wound-healing, revealing mechanism targeting microfibril-associated glycoprotein 4 (MFAP4) associated signaling pathway.To investigate healing, cell viability, migration, proliferation assay was performed. This followed by quantitative real-time polymerase chain reaction Western blot analyses wounded conditions check mixture protein mRNA levels normal human dermal fibroblast (NHDF) cells. Moreover, small interfering RNA (siRNA) -mediated knockdown MFAP4 NHDF cells performed migration cycle analysis, confirm role healing. Additionally, HaCaT were evaluate migratory anti-inflammatory effects.Based obtained results, PAG AVF synergistically induced proliferation, especially ECM formation enhancing expression MFAP4. Other extracellular components pathway, such fibrillin, collagen, elastin, TGF β, α-SMA, increased at both levels. Subsequently, initiated phosphorylation signal-regulated kinase (ERK) AKT pathways, S-phase slightly modified. Also, along suppression inflammatory cytokines. siRNA-mediated highlighted crucial cells.This showed significant pathway. recognized new biomarker which can be further studies.

Язык: Английский

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