Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics

Genes & Diseases, Год журнала: 2022, Номер 10(4), С. 1367 - 1401

Опубликована: Март 18, 2022

Cancer is an abnormal state of cells where they undergo uncontrolled proliferation and produce aggressive malignancies that causes millions deaths every year. With the new understanding molecular mechanism(s) disease progression, our knowledge about snowballing, leading to evolution many therapeutic regimes their successive trials. In past few decades, various combinations therapies have been proposed are presently employed in treatment diverse cancers. Targeted drug therapy, immunotherapy, personalized medicines now largely being employed, which were not common a years back. The field cancer discoveries therapeutics evolving fast as type-specific biomarkers progressively identified several types cancers nowadays undergoing systematic therapies, extending patients' disease-free survival thereafter. Although growing evidence shows targeted approach could be future medicine, chemotherapy remains opted option despite its known side effects on patient's physical psychological health. Chemotherapeutic agents/pharmaceuticals served great purpose over decades remained frontline choice for advanced-stage surgery and/or radiation therapy cannot prescribed due specific reasons. present report succinctly reviews existing contemporary advancements assesses status enrolled drugs/pharmaceuticals; it also comprehensively discusses emerging role specific/targeted strategies achieve better clinical success/survival rate patients.

Язык: Английский

---

Safer plant-based nanoparticles for combating antibiotic resistance in bacteria: A comprehensive review on its potential applications, recent advances, and future perspective

The Science of The Total Environment, Год журнала: 2022, Номер 821, С. 153472 - 153472

Опубликована: Янв. 29, 2022

Antibiotic resistance is one of the current threats to human health, forcing use drugs that are more noxious, costlier, and with low efficiency. There several causes behind antibiotic resistance, including over-prescription antibiotics in both humans livestock. In this scenario, researchers shifting new alternatives fight back concerning situation.

Язык: Английский

---

Betelvine (Piper betleL.): A comprehensive insight into its ethnopharmacology, phytochemistry, and pharmacological, biomedical and therapeutic attributes

Journal of Cellular and Molecular Medicine, Год журнала: 2022, Номер 26(11), С. 3083 - 3119

Опубликована: Май 2, 2022

Piper betle L. (synonym: betel Blanco), or vine, an economically and medicinally important cash crop, belongs to the family Piperaceae, often known as green gold. The plant can be found all over world is cultivatedprimarily in South East Asian countries for its beautiful glossy heart-shaped leaves, which are chewed consumed betelquidand widely used Chinese Indian folk medicine, carminative, stimulant,astringent, against parasitic worms, conjunctivitis, rheumatism, wound, etc., andis also religious purposes. Hydroxychavicol most bioactive compound among wide range of phytoconstituents essential oil extracts. pharmacological attributes P. antiproliferation, anticancer, neuropharmacological, analgesic, antioxidant, antiulcerogenic, hepatoprotective, antifertility, antibacterial, antifungal many more. Immense attention has been paid nanoformulations their applications. application did not show cytotoxicity preclinical experiments, suggesting that it could serve a promising therapeutic candidate different diseases. present review comprehensively summarizes botanical description, geographical distribution, economic value cultivation, ethnobotanical uses, properties with insights toxicological, clinical efficacy, safety betle. findings suggest represents orally active safe natural agent exhibits great potential managing various human medical conditions. However, further research needed elucidate underlying molecular mechanisms action, aspects, structure-activity relationships, bioavailability synergistic interactions other drugs.

Язык: Английский

---

Therapeutic Role of Alkaloids and Alkaloid Derivatives in Cancer Management

Molecules, Год журнала: 2023, Номер 28(14), С. 5578 - 5578

Опубликована: Июль 22, 2023

Cancer is a neoplastic disease that remains global challenge with reported prevalence increasing annually. Though existing drugs can be applied as single or combined therapies for managing this pathology, their concomitant adverse effects in human applications have led to the need continually screen natural products effective and alternative anticancer bioactive principles. Alkaloids are chemical molecules that, due structural diversity, constitute reserve discovery of lead compounds interesting pharmacological activities. Several vitro studies few vivo findings documented various cytotoxic antiproliferative properties alkaloids. This review describes chaetocochin J, neopapillarine, coclaurine, reflexin A, 3,10-dibromofascaplysin neferine, which belong different alkaloid classes antineoplastic been identified recently from plants. Despite low solubility bioavailability, plant-derived alkaloids viable prospects sources antitumor agents. potential achieved if more research on these directed toward investigating ways improving delivery an active form close target cells, preferably no effect neighboring normal tissues.

Язык: Английский

---

Recent advance on carbamate-based cholinesterase inhibitors as potential multifunctional agents against Alzheimer's disease

European Journal of Medicinal Chemistry, Год журнала: 2022, Номер 240, С. 114606 - 114606

Опубликована: Июль 16, 2022

Язык: Английский

---

Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence

Antioxidants, Год журнала: 2023, Номер 12(6), С. 1159 - 1159

Опубликована: Май 26, 2023

Reactive oxygen species (ROS) are metabolic byproducts that regulate various cellular processes. However, at high levels, ROS induce oxidative stress, which in turn can trigger cell death. Cancer cells alter the redox homeostasis to facilitate protumorigenic processes; however, this leaves them vulnerable further increases levels. This paradox has been exploited as a cancer therapeutic strategy with use of pro-oxidative drugs. Many chemotherapeutic drugs presently clinical use, such cisplatin and doxorubicin, one their mechanisms action. Further, drugs, including phytochemicals small molecules, being investigated preclinical studies attribute anticancer activity induction. Consistently, review aims highlight selected whose potential characterized specific focus on phytochemicals, induction, effects downstream

Язык: Английский

---

Piperine-coated zinc oxide nanoparticles target biofilms and induce oral cancer apoptosis via BCl-2/BAX/P53 pathway

BMC Oral Health, Год журнала: 2024, Номер 24(1)

Опубликована: Июнь 21, 2024

Abstract Background Dental pathogens play a crucial role in oral health issues, including tooth decay, gum disease, and infections, recent research suggests link between these cancer initiation progression. Innovative therapeutic approaches are needed due to antibiotic resistance concerns treatment limitations. Methods We synthesized analyzed piperine-coated zinc oxide nanoparticles (ZnO-PIP NPs) using UV spectroscopy, SEM, XRD, FTIR, EDAX. Antioxidant antimicrobial effectiveness were evaluated through DPPH, ABTS, MIC assays, while the anticancer properties assessed on KB squamous carcinoma cells. Results ZnO-PIP NPs exhibited significant antioxidant activity of 50 µg/mL against dental pathogens, indicating strong properties. Interaction analysis revealed high binding affinity with pathogens. showed dose-dependent cells, upregulating apoptotic genes BCL2, BAX, P53. Conclusions This approach offers multifaceted solution combatting both infections cancer, showcasing their potential for advancement healthcare. It is essential acknowledge limitations challenges associated use ZnO clinical applications. These may include regarding nanoparticle toxicity, biocompatibility, long-term safety. Further rigorous testing warranted address issues ensure safe effective translation into practice.

Язык: Английский

---

Deep learning for medicinal plant species classification and recognition: a systematic review

Frontiers in Plant Science, Год журнала: 2024, Номер 14

Опубликована: Янв. 5, 2024

Knowledge of medicinal plant species is necessary to preserve plants and safeguard biodiversity. The classification identification these by botanist experts are complex time-consuming activities. This systematic review’s main objective systematically assess the prior research efforts on applications usage deep learning approaches in classifying recognizing species. Our was pinpoint reviews following PRISMA guidelines related recognition through utilization techniques. review encompassed studies published between January 2018 December 2022. Initially, we identified 1644 title, keyword, abstract screening. After applying our eligibility criteria, selected 31 for a thorough critical review. findings this (1) were carried out 16 different countries, India leads paper contributions with 29%, followed Indonesia Sri Lanka. (2) A private dataset has been used 67.7% subjected image augmentation preprocessing (3) In 96.7% studies, researchers have employed leaf organs, 74% them utilizing shapes (4) Transfer pre-trained model 83.8% as future extraction technique. (5) Convolutional Neural Network (CNN) 64.5% classifier. (6) lack globally available public need indigenous specific country trustworthiness approach an observable gap literature Therefore, further investigations collaboration stakeholders required fulfilling aforementioned gaps.

Язык: Английский

---

Poly (ADP-ribose) polymerase (PARP) inhibitors as anticancer agents: An outlook on clinical progress, synthetic strategies, biological activity, and structure-activity relationship

European Journal of Medicinal Chemistry, Год журнала: 2024, Номер 274, С. 116535 - 116535

Опубликована: Май 31, 2024

Язык: Английский

---

Synthesis of Spiro[indoline-pyridine]-dicarboxylates and Substituted Alkylidene Oxindoles by Azomethine Ylides and MBH Carbonates of Isatins

Organic Letters, Год журнала: 2024, Номер 26(19), С. 4117 - 4121

Опубликована: Май 9, 2024

We have developed an efficient protocol for the synthesis of spiro[indoline-pyridine]dicarboxylates and substituted alkylidene oxindoles through [3 + 3] cycloaddition Michael addition individually by azomethine ylides various MBH carbonates isatins. The selective generation cyclic products chain was achieved changing substituents at 3-position oxindoles. features this method include convenient catalysts, mild reaction conditions, broad substrate scopes.

Язык: Английский

---