Evidence-based Complementary and Alternative Medicine,
Год журнала:
2022,
Номер
2022, С. 1 - 11
Опубликована: Июль 30, 2022
The
lower
respiratory
tract
infection,
induced
by
influenza
virus,
coronaviruses,
and
syncytial
remains
a
serious
threat
to
human
health
that
can
cause
global
pandemic.
Thus,
finding
effective
chemicals
therapeutic
measures
advance
the
functional
restoration
of
after
infection
has
been
emphasis
studies
on
subjects.
Mosla
scabra
is
natural
medicinal
plant
used
for
treating
various
lung
gastrointestinal
diseases,
including
viral
cough,
chronic
obstructive
pulmonary
disease,
acute
gastroenteritis,
diarrhoea.
In
this
study,
antiviral
anti-inflammatory
effects
total
lignans
(MSTL)
extracted
from
were
investigated
in
A
virus
(IAV)-infected
mice
RAW
264.7
macrophages.
MSTL
could
not
only
protect
macrophages
against
IAV-induced
pyroptosis
but
also
lighten
inflammation
IAV
vivo
vitro.
network
pharmacology
analysis
revealed
differentially
expressed
genes,
mainly
involving
EGFR
tyrosine
kinase
inhibitor
resistance,
endocrine
HIF-1
signaling
pathway,
C-type
lectin
receptor
FOXO
contributed
alveolar
macrophage
dysfunction.
It
indicated
enhanced
function
improved
injury
mice.
Chinese Herbal Medicines,
Год журнала:
2024,
Номер
16(4), С. 505 - 520
Опубликована: Авг. 23, 2024
L.
(Araliaceae)
has
a
long
history
of
medicinal
and
edible
use
due
to
its
significant
tonifying
effects,
ginseng
research
been
hot
topic
in
natural
products
food
science.
In
continuation
our
recent
review,
we
highlighted
the
advances
from
2021
2023
with
157
citations,
which
exhibited
increasingly
systematic,
collaborative,
intelligent
characteristics.
this
firstly
updated
progress
phytochemistry
involving
ginsenosides
polysaccharides
summarized
researches
on
active
components.
Then,
some
specific
applications
by
feat
multidimensional
chromatography,
mass
spectrometry
imaging,
DNA
barcoding,
metabolomics,
were
analyzed,
could
provide
rich
information
supporting
multi-component
characterization,
authentication,
quality
control
versatile
products.
Finally,
biosynthesis
studies
concerning
retrospected.
Additionally,
current
challenges
future
trends
respect
discussed.
Mass Spectrometry Reviews,
Год журнала:
2022,
Номер
42(5), С. 2207 - 2233
Опубликована: Сен. 22, 2022
Abstract
Safety
issues
caused
by
pharmaceuticals
have
frequently
occurred
worldwide,
posing
a
tremendous
threat
to
human
health.
As
an
essential
part
of
drug
development,
the
toxicological
analysis
and
safety
evaluation
is
great
significance.
In
addition,
risk
accumulation
in
environment
monitoring
toxicity
from
natural
medicines
also
received
ongoing
concerns.
Due
lack
spatial
distribution
information
provided
common
analytical
methods,
analyses
that
provide
dimensions
could
serve
as
complementary
methods
for
better
prediction
toxicity.
With
advances
technical
solutions
software
algorithms,
mass
spectrometry
imaging
(MSI)
has
increasing
attention
popular
tool
enables
simultaneous
implementation
qualitative,
quantitative,
localization
without
complex
sample
pretreatment
labeling
steps.
recent
years,
MSI
become
more
attractive,
powerful,
sensitive
been
applied
several
scientific
fields
can
meet
assessment
requirements.
This
review
aims
cover
detailed
summary
various
technologies
utilized
biomedical
pharmaceutical
area,
including
principles,
advantages,
current
status,
future
trends.
Representative
applications
developments
safety‐related
different
are
described
reference
research,
improve
rational
clinical
medicine
use,
ensure
public
safety.
Phytochemical Analysis,
Год журнала:
2022,
Номер
34(1), С. 139 - 148
Опубликована: Ноя. 14, 2022
The
main
chemical
components
of
Angelica
dahurica
(Hoffm.)
Benth.
&
Hook.f.
ex
Franch.
Sav.
are
coumarins
and
volatile
oils,
regarded
as
the
representative
constituents
with
various
pharmacological
effects.Based
on
matrix-assisted
laser
desorption/ionization
time
flight
mass
spectrometry
imaging
(MALDI-TOF-MSI),
a
method
for
spatial
distribution
analysis
in
primary
root
lateral
A.
was
established.
Also,
visualization
roots
realized.α-Cyano-4-hydroxycinnamic
acid
(CHCA),
2,5-dihydroxybenzoic
acid,
9-aminoacridine
were
used
matrices.
MALDI-TOF-MSI
employed
to
analyze
standards
imperatorin,
oxypeucedanin,
osthole.
Based
higher
sensitivity
repeatability
MALDI-TOF-MSI,
CHCA
matrix
selected.
positive
mode
dahurica.In
total,
37
detected
36
by
MALDI-TOF-MSI.
results
showed
that
coumarin
content
than
root.
Coumarins
concentrated
periderm,
cortex,
phloem,
whereas
phloem.The
directly
analyzed
without
extraction
isolation,
comprehensively
visualized
first
which
provided
basis
distinguishing
Evidence-based Complementary and Alternative Medicine,
Год журнала:
2022,
Номер
2022, С. 1 - 11
Опубликована: Июль 30, 2022
The
lower
respiratory
tract
infection,
induced
by
influenza
virus,
coronaviruses,
and
syncytial
remains
a
serious
threat
to
human
health
that
can
cause
global
pandemic.
Thus,
finding
effective
chemicals
therapeutic
measures
advance
the
functional
restoration
of
after
infection
has
been
emphasis
studies
on
subjects.
Mosla
scabra
is
natural
medicinal
plant
used
for
treating
various
lung
gastrointestinal
diseases,
including
viral
cough,
chronic
obstructive
pulmonary
disease,
acute
gastroenteritis,
diarrhoea.
In
this
study,
antiviral
anti-inflammatory
effects
total
lignans
(MSTL)
extracted
from
were
investigated
in
A
virus
(IAV)-infected
mice
RAW
264.7
macrophages.
MSTL
could
not
only
protect
macrophages
against
IAV-induced
pyroptosis
but
also
lighten
inflammation
IAV
vivo
vitro.
network
pharmacology
analysis
revealed
differentially
expressed
genes,
mainly
involving
EGFR
tyrosine
kinase
inhibitor
resistance,
endocrine
HIF-1
signaling
pathway,
C-type
lectin
receptor
FOXO
contributed
alveolar
macrophage
dysfunction.
It
indicated
enhanced
function
improved
injury
mice.
