Rhodiola crenulata alleviates hypobaric hypoxia-induced brain injury by maintaining BBB integrity and balancing energy metabolism dysfunction

Phytomedicine, Год журнала: 2024, Номер 128, С. 155529 - 155529

Опубликована: Март 11, 2024

Язык: Английский

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Caffeic acid alleviates cerebral ischemic injury in rats by resisting ferroptosis via Nrf2 signaling pathway

Acta Pharmacologica Sinica, Год журнала: 2023, Номер 45(2), С. 248 - 267

Опубликована: Окт. 13, 2023

Язык: Английский

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Scutellarin attenuates oxidative stress and neuroinflammation in cerebral ischemia/reperfusion injury through PI3K/Akt-mediated Nrf2 signaling pathways

European Journal of Pharmacology, Год журнала: 2023, Номер 957, С. 175979 - 175979

Опубликована: Авг. 21, 2023

Cerebral ischemia/reperfusion injury (CIRI) seriously threatens human life and health. Scutellarin (Scu) exhibits neuroprotective effects, but little is known about its underlying mechanism. Therefore, we explored protective effect on CIRI the Our results demonstrated that Scu rescued HT22 cells from cytotoxicity induced by oxygen glucose deprivation/reoxygenation (OGD/R). also showed antioxidant activity promoting nuclear factor erythroid 2-related 2 (Nrf2) translocation, upregulating heme oxygenase-1 (HO-1) expression, increasing superoxide dismutase (SOD) activity, inhibiting reactive species (ROS) generation in vitro. Additionally, reduced factor-kappa B (NF-κB) levels of pro-inflammatory factors. Interestingly, these effects were abolished Nrf2 inhibition. Furthermore, infarct volume blood-brain barrier (BBB) permeability, improved sensorimotor functions depressive behaviors, alleviated oxidative stress neuroinflammation rats subjected to middle cerebral artery occlusion/reperfusion (MCAO/R). Mechanistically, Scu-induced accumulation inactivation NF-κB accompanied an enhanced level phosphorylated protein kinase (p-AKT) both vitro vivo. Pharmacologically phosphatidylinositol-3-kinase/protein (PI3K/AKT) pathway blocked translocation NF-κB, as well anti-inflammatory activities. In summary, suggest antioxidant, anti-inflammatory, through activation mediated PI3K/Akt pathway.

Язык: Английский

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Mitochondrial oxidative stress in brain microvascular endothelial cells: Triggering blood-brain barrier disruption

Mitochondrion, Год журнала: 2023, Номер 69, С. 71 - 82

Опубликована: Янв. 26, 2023

Blood-brain barrier disruption plays an important role in central nervous system diseases. This review provides information on the of mitochondrial oxidative stress brain microvascular endothelial cells cellular dysfunction, intercellular junctions, transporter abnormal angiogenesis, neurovascular decoupling, and involvement aggravation vascular inflammation illustrates related molecular mechanisms. In addition, recent drug nondrug therapies targeting cerebral cell mitochondria to repair blood–brain are discussed. shows that disorder a key occurrence development damage may be critical various pathological mechanisms damage. These new findings suggest potential strategy for treatment diseases through modulation cells.

Язык: Английский

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Scutellarin ameliorates mitochondrial dysfunction and apoptosis in OGD/R-insulted HT22 cells through mitophagy induction

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 179, С. 117340 - 117340

Опубликована: Авг. 27, 2024

Scutellarin (Scu), a flavonoid from herbal Erigeron breviscapus (Vaniot) Hand-Mazz, exerts neuroprotective effects against cerebral ischemia. However, whether the of Scu are related to mitochondrial protection needs further investigation. In this study, we aimed clarify mechanisms HT22 cells injury caused by oxygen-glucose deprivation and reperfusion (OGD/R). Our results proved that significantly reduced overload intracellular reactive oxygen species (cellar ROS) mitochondria (mito-ROS), ameliorating oxidative stress damage. TUNEL positive rate, Caspase-3 activity, Cytochrome c (Cyto-c) expression remarkably decreased following treatment. Meanwhile, could maintain morphology reverse ultrastructure changes. And membrane potential (MMP), consumption rate (OCR), adenosine triphosphate (ATP) production Na

Язык: Английский

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Berberis dictyophylla F. inhibits angiogenesis and apoptosis of diabetic retinopathy via suppressing HIF-1α/VEGF/DLL-4/Notch-1 pathway

Journal of Ethnopharmacology, Год журнала: 2022, Номер 296, С. 115453 - 115453

Опубликована: Июнь 11, 2022

Язык: Английский

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Anti-apoptosis effect of traditional Chinese medicine in the treatment of cerebral ischemia–reperfusion injury

APOPTOSIS, Год журнала: 2023, Номер 28(5-6), С. 702 - 729

Опубликована: Март 9, 2023

Язык: Английский

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Signaling pathways in brain ischemia: Mechanisms and therapeutic implications

Pharmacology & Therapeutics, Год журнала: 2023, Номер 251, С. 108541 - 108541

Опубликована: Окт. 1, 2023

Язык: Английский

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Cerebral glucagon‐like peptide‐1 receptor activation alleviates traumatic brain injury by glymphatic system regulation in mice

CNS Neuroscience & Therapeutics, Год журнала: 2023, Номер 29(12), С. 3876 - 3888

Опубликована: Июнь 23, 2023

Abstract Aim We aimed to assess the effects of cerebral glucagon‐like peptide‐1 receptor (GLP‐1R) activation on glymphatic system and whether this effect was therapeutic for traumatic brain injury (TBI). Methods Immunofluorescence employed evaluate function. The blood–brain barrier (BBB) permeability, microvascular basement membrane, tight junction expression were assessed using Evans blue extravasation, immunofluorescence, western blot. Immunohistochemistry performed axonal damage. Neuronal apoptosis evaluated Nissl staining, terminal deoxynucleotidyl transferase‐mediated dUTP nick end labeling (TUNEL) Cognitive function behavioral tests. Results Cerebral GLP‐1R restored transport following TBI, alleviating BBB disruption neuronal apoptosis, thereby improving cognitive TBI. Glymphatic suppression by treatment aquaporin 4 inhibitor TGN‐020 abolished protective agonist against impairment. Conclusion can effectively ameliorate neuropathological changes impairment TBI; underlying mechanism could involve repair damaged

Язык: Английский

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E2F1/CDK5/DRP1 axis mediates microglial mitochondrial division and autophagy in the pathogenesis of cerebral ischemia‐reperfusion injury

Clinical and Translational Medicine, Год журнала: 2025, Номер 15(2)

Опубликована: Фев. 1, 2025

Язык: Английский

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