Naoxintong capsule accelerates mitophagy in cerebral ischemia-reperfusion injury via TP53/PINK1/PRKN pathway based on network pharmacology analysis and experimental validation DOI
Jinfeng Shang,

Yinlian Wen,

Xiaolu Zhang

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 336, P. 118721 - 118721

Published: Aug. 22, 2024

Language: Английский

Rhodiola crenulata alleviates hypobaric hypoxia-induced brain injury by maintaining BBB integrity and balancing energy metabolism dysfunction DOI

Ya Hou,

Fuhan Fan,

Na Xie

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 128, P. 155529 - 155529

Published: March 11, 2024

Language: Английский

Citations

32
Caffeic acid alleviates cerebral ischemic injury in rats by resisting ferroptosis via Nrf2 signaling pathway DOI
Xinnan Li,

Nian-ying Shang,

Yu-ying Kang

et al.

Acta Pharmacologica Sinica, Journal Year: 2023, Volume and Issue: 45(2), P. 248 - 267

Published: Oct. 13, 2023

Language: Английский

Citations

36
Mitochondrial oxidative stress in brain microvascular endothelial cells: Triggering blood-brain barrier disruption DOI Creative Commons

Yi Wang,

Jing Wu, Jiexin Wang

et al.

Mitochondrion, Journal Year: 2023, Volume and Issue: 69, P. 71 - 82

Published: Jan. 26, 2023

Blood-brain barrier disruption plays an important role in central nervous system diseases. This review provides information on the of mitochondrial oxidative stress brain microvascular endothelial cells cellular dysfunction, intercellular junctions, transporter abnormal angiogenesis, neurovascular decoupling, and involvement aggravation vascular inflammation illustrates related molecular mechanisms. In addition, recent drug nondrug therapies targeting cerebral cell mitochondria to repair blood–brain are discussed. shows that disorder a key occurrence development damage may be critical various pathological mechanisms damage. These new findings suggest potential strategy for treatment diseases through modulation cells.

Language: Английский

Citations

30
Scutellarin attenuates oxidative stress and neuroinflammation in cerebral ischemia/reperfusion injury through PI3K/Akt-mediated Nrf2 signaling pathways DOI Creative Commons
Xueheng Xie, Handong Wang,

Wenxiu Ge

et al.

European Journal of Pharmacology, Journal Year: 2023, Volume and Issue: 957, P. 175979 - 175979

Published: Aug. 21, 2023

Cerebral ischemia/reperfusion injury (CIRI) seriously threatens human life and health. Scutellarin (Scu) exhibits neuroprotective effects, but little is known about its underlying mechanism. Therefore, we explored protective effect on CIRI the Our results demonstrated that Scu rescued HT22 cells from cytotoxicity induced by oxygen glucose deprivation/reoxygenation (OGD/R). also showed antioxidant activity promoting nuclear factor erythroid 2-related 2 (Nrf2) translocation, upregulating heme oxygenase-1 (HO-1) expression, increasing superoxide dismutase (SOD) activity, inhibiting reactive species (ROS) generation in vitro. Additionally, reduced factor-kappa B (NF-κB) levels of pro-inflammatory factors. Interestingly, these effects were abolished Nrf2 inhibition. Furthermore, infarct volume blood-brain barrier (BBB) permeability, improved sensorimotor functions depressive behaviors, alleviated oxidative stress neuroinflammation rats subjected to middle cerebral artery occlusion/reperfusion (MCAO/R). Mechanistically, Scu-induced accumulation inactivation NF-κB accompanied an enhanced level phosphorylated protein kinase (p-AKT) both vitro vivo. Pharmacologically phosphatidylinositol-3-kinase/protein (PI3K/AKT) pathway blocked translocation NF-κB, as well anti-inflammatory activities. In summary, suggest antioxidant, anti-inflammatory, through activation mediated PI3K/Akt pathway.

Language: Английский

Citations

30
Scutellarin ameliorates mitochondrial dysfunction and apoptosis in OGD/R-insulted HT22 cells through mitophagy induction DOI Open Access
Lu Yang, Xianfeng Liu,

Siyin Chen

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 179, P. 117340 - 117340

Published: Aug. 27, 2024

Scutellarin (Scu), a flavonoid from herbal Erigeron breviscapus (Vaniot) Hand-Mazz, exerts neuroprotective effects against cerebral ischemia. However, whether the of Scu are related to mitochondrial protection needs further investigation. In this study, we aimed clarify mechanisms HT22 cells injury caused by oxygen-glucose deprivation and reperfusion (OGD/R). Our results proved that significantly reduced overload intracellular reactive oxygen species (cellar ROS) mitochondria (mito-ROS), ameliorating oxidative stress damage. TUNEL positive rate, Caspase-3 activity, Cytochrome c (Cyto-c) expression remarkably decreased following treatment. Meanwhile, could maintain morphology reverse ultrastructure changes. And membrane potential (MMP), consumption rate (OCR), adenosine triphosphate (ATP) production Na

Language: Английский

Citations

10
E2F1/CDK5/DRP1 axis mediates microglial mitochondrial division and autophagy in the pathogenesis of cerebral ischemia‐reperfusion injury DOI Creative Commons

Yongpeng Yuan,

Tingting Chen, Yanling Yang

et al.

Clinical and Translational Medicine, Journal Year: 2025, Volume and Issue: 15(2)

Published: Feb. 1, 2025

Language: Английский

Citations

1
Berberis dictyophylla F. inhibits angiogenesis and apoptosis of diabetic retinopathy via suppressing HIF-1α/VEGF/DLL-4/Notch-1 pathway DOI

Xiaopeng Ai,

Peiling Yu,

Liuling Luo

et al.

Journal of Ethnopharmacology, Journal Year: 2022, Volume and Issue: 296, P. 115453 - 115453

Published: June 11, 2022

Language: Английский

Citations

29
Signaling pathways in brain ischemia: Mechanisms and therapeutic implications DOI

Wen Lin,

Xiaosu Zhao, Jiawen Cheng

et al.

Pharmacology & Therapeutics, Journal Year: 2023, Volume and Issue: 251, P. 108541 - 108541

Published: Oct. 1, 2023

Language: Английский

Citations

21
Anti-apoptosis effect of traditional Chinese medicine in the treatment of cerebral ischemia–reperfusion injury DOI
Nan Zhao, Yuhe Gao,

Hongtao Jia

et al.

APOPTOSIS, Journal Year: 2023, Volume and Issue: 28(5-6), P. 702 - 729

Published: March 9, 2023

Language: Английский

Citations

19
Cerebral glucagon‐like peptide‐1 receptor activation alleviates traumatic brain injury by glymphatic system regulation in mice DOI Creative Commons
Chuanxiang Lv, Shuai Han, Zhuang Sha

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2023, Volume and Issue: 29(12), P. 3876 - 3888

Published: June 23, 2023

Abstract Aim We aimed to assess the effects of cerebral glucagon‐like peptide‐1 receptor (GLP‐1R) activation on glymphatic system and whether this effect was therapeutic for traumatic brain injury (TBI). Methods Immunofluorescence employed evaluate function. The blood–brain barrier (BBB) permeability, microvascular basement membrane, tight junction expression were assessed using Evans blue extravasation, immunofluorescence, western blot. Immunohistochemistry performed axonal damage. Neuronal apoptosis evaluated Nissl staining, terminal deoxynucleotidyl transferase‐mediated dUTP nick end labeling (TUNEL) Cognitive function behavioral tests. Results Cerebral GLP‐1R restored transport following TBI, alleviating BBB disruption neuronal apoptosis, thereby improving cognitive TBI. Glymphatic suppression by treatment aquaporin 4 inhibitor TGN‐020 abolished protective agonist against impairment. Conclusion can effectively ameliorate neuropathological changes impairment TBI; underlying mechanism could involve repair damaged

Language: Английский

Citations

18